Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Fiona Fernandes"'
Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47
Autor:
Jessica P Wiseman, Joseph M Scarrott, João Alves-Cruzeiro, Afshin Saffari, Cedric Böger, Evangelia Karyka, Emily Dawes, Alexandra K Davies, Paolo M Marchi, Emily Graves, Fiona Fernandes, Zih-Liang Yang, Ian Coldicott, Jennifer Hirst, Christopher P Webster, J Robin Highley, Neil Hackett, Adrienn Angyal, Thushan de Silva, Adrian Higginbottom, Pamela J Shaw, Laura Ferraiuolo, Darius Ebrahimi-Fakhari, Mimoun Azzouz
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2882-2917 (2024)
Abstract Spastic paraplegia 47 (SPG47) is a neurological disorder caused by mutations in the adaptor protein complex 4 β1 subunit (AP4B1) gene leading to AP-4 complex deficiency. SPG47 is characterised by progressive spastic paraplegia, global devel
Externí odkaz:
https://doaj.org/article/7525f462e89f4274b18148dc6adcb126
Autor:
Alvino Maestri, Su Eun Park, Fiona Fernandes, Zhongyi “Lucy” Li, Yae-Jean Kim, Yun-Kyung Kim, Jin Lee, Ji Young Park, Dong Hyun Kim, GyongSeon Yang, Hyunjung Lim, Jin Oh Kim, Robert Lupinacci, Tina M. Sterling, Marissa Wilck, Alejandra Esteves-Jaramillo, Natalie Banniettis
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
ABSTRACTThere is an ongoing burden of pneumococcal disease in children despite the use of pneumococcal conjugate vaccines (PCVs). This phase 3, open-label, single-arm, multisite, descriptive study was designed to evaluate the safety and immunogenicit
Externí odkaz:
https://doaj.org/article/bee75b52b4b44c919cf78d85f82b27ea
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9815 (2010)
Hepatitis C Virus (HCV) infection is a leading indication for liver transplantation. HCV infection reoccurs almost universally post transplant, decreasing both graft longevity and patient survival. The immunosuppressant, cyclosporine A (CsA) has pote
Externí odkaz:
https://doaj.org/article/deab615814074b43a027b790af104905
Autor:
Michael E Abram, Bahar Ahani, David E Tabor, Fiona Fernandes, Deidre Wilkins, Anastasia A Aksyuk, Kevin M Tuffy, Hong Ji, Christine Blaze, Tyler Brady, Pamela Griffin, Amanda Leach, Tonya L Villafana, Mark T Esser
Publikováno v:
Open Forum Infectious Diseases. 9
Background Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection (LRTI) and hospitalization in infants. In two global pivotal placebo-controlled studies, nirsevimab, a monoclonal antibody to the RSV prefusion (F) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93db9da2cebce7f4aa7876bbf02658aa
https://doi.org/10.1093/ofid/ofac492.019
https://doi.org/10.1093/ofid/ofac492.019
Autor:
Dimple Pathania, Ankita Araballi, Fiona Fernandes, Jyothi Mannekote Shivanna, Ganesan Sriram, Mahaveer Kurkuri, Gurumurthy Hegde, Tejraj M. Aminabhavi
Publikováno v:
Environmental Research. 224:115521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e65813b8ffa5d276c7762f37b231d1f
https://doi.org/10.1016/j.envres.2023.115521
https://doi.org/10.1016/j.envres.2023.115521
Publikováno v:
Current Stem Cell Research & Therapy. 15:155-172
Stem cell-based regenerative medicine holds exceptional therapeutic potential and hence the development of efficient techniques to enhance control over the rate of differentiation has been the focus of active research. One of the strategies to achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf550b3e31065b8acb717f0e8f9cd91
https://doi.org/10.2174/1574888x14666191202095041
https://doi.org/10.2174/1574888x14666191202095041
Publikováno v:
Current Physical Chemistry. 9:94-109
Fluorescence based bioimaging is one of the widely used method for obtaining imperative information on life processes. Objective: Within the expansive spectrum of fluorescent agents being investigated, the trivalent Lanthanide (Ln) ion based nanopart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a5c92f9e7ee2c51cb9d7b90141371f5
https://doi.org/10.2174/1877946809666190828104812
https://doi.org/10.2174/1877946809666190828104812
Autor:
Niels Vrang, Fiona Fernandes, Bret R. Sellman, Taylor S. Cohen, Andrey Tovchigrechko, Michael Feigh, Michelle L. Boland, Jacob Jelsing, Jens Nielsen, Sanne Skovgård Veidal, James L. Trevaskis, Henrik H. Hansen, Kirstine S Tølbøl, David E. Tabor, Denise Oró, Paul Warrener, Sebastian T. Thrane
Publikováno v:
World Journal of Gastroenterology
BACKGROUND The trans-fat containing AMLN (amylin liver non-alcoholic steatohepatitis, NASH) diet has been extensively validated in C57BL/6J mice with or without the Lepob/Lepob (ob/ob) mutation in the leptin gene for reliably inducing metabolic and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10727d80256829059ab62239b9213c29
https://doi.org/10.3748/wjg.v25.i33.4904
https://doi.org/10.3748/wjg.v25.i33.4904
Autor:
Michael E Abram, Deidre E. Wilkins, Fiona Fernandes, Mark T. Esser, Robert Jan Lebbink, Alexey Ruzin, Leyla Kragten-Tabatabaie, Annefleur C Langedijk, Andrey Tovchigrechko, Hong Jin, David E. Tabor, Louis Bont
Publikováno v:
Journal of Clinical Microbiology
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV is a multiyear clinical study designed to describe the global molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9311f01fe805c4da4969442d77bdb4
http://europepmc.org/articles/PMC7771447
http://europepmc.org/articles/PMC7771447
Autor:
Nicole L. Kallewaard, Susan R. Palaszynski, Steve Wong, Fiona Fernandes, Weijia Wang, Seme Diallo, Nancy Ulbrandt, Mark T. Esser, Bin Lu, Catherine Svabek, Patrick M. Mctamney, Kuishu Ren, Qing Zhu, Hong Jing, JoAnn Suzich, Brian Moldt
Publikováno v:
The Journal of Infectious Diseases. 218:572-580
Background Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children. To date, no vaccine is approved for the broad population of healthy infants. MEDI8897, a potent anti-RSV fusion a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535133194e5dfc1175900a74f9ef7957
https://doi.org/10.1093/infdis/jiy189
https://doi.org/10.1093/infdis/jiy189