Výsledky vyhledávání - "Fiona Errington"

Akademický článek

Natural killer cells are required for the recruitment of CD8+ T cells and the efficacy of immune checkpoint blockade in melanoma brain metastases

Autor: Marlous Hall, Jennifer Williams, Fiona Errington-Mais, Tereza Andreou, Rebecca J Brownlie, Robert J Salmond, Mihaela Lorger, Scott Gregory, Fiona James, Christopher Fife, Ashley Sunderland, Clive McKimmie, Samuel Heaton, Zarnaz Hadi, David R Westhead, Alexander Davie, Amber Emmett

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)

Background Brain metastases (BrM) affect up to 60% of patients with metastatic melanoma and are associated with poor prognosis. While combined immune checkpoint blockade of programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CT

Externí odkaz: https://doaj.org/article/3bcea94ec8a94258978f49f726d9e04e

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Akademický článek

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)

Background Over the past decade, cancer immunotherapies have revolutionized the treatment of melanoma; however, responses vary across patient populations. Recently, baseline tumor size has been identified as an independent prognostic factor for overa

Externí odkaz: https://doaj.org/article/2760efb5528c442eb6992610bc801ce3

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Akademický článek

Efficacy of coxsackievirus A21 against drug-resistant neoplastic B cells

Autor: Matthew Holmes, Gina B. Scott, Samuel Heaton, Tyler Barr, Basem Askar, Louise M.E. Müller, Victoria A. Jennings, Christy Ralph, Cathy Burton, Alan Melcher, Peter Hillmen, Christopher Parrish, Fiona Errington-Mais

Publikováno v: Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 17-29 (2023)

Primary drug resistance and minimal residual disease are major challenges in the treatment of B cell neoplasms. Therefore, this study aimed to identify a novel treatment capable of eradicating malignant B cells and drug-resistant disease. Oncolytic v

Externí odkaz: https://doaj.org/article/5203c050e9894f55a9405ad6fce9ab42

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Akademický článek

CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)

Background Combination herpes simplex virus (HSV) oncolytic virotherapy and BRAF inhibitors (BRAFi) represent promising immunogenic treatments for BRAF mutant melanoma, but an improved understanding of the immunobiology of combinations is needed to i

Externí odkaz: https://doaj.org/article/316204113b0e4019ac28423a26ae7cf2

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Akademický článek

Plasmacytoid dendritic cells orchestrate innate and adaptive anti-tumor immunity induced by oncolytic coxsackievirus A21

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)

Abstract Background The oncolytic virus, coxsackievirus A21 (CVA21), has shown promise as a single agent in several clinical trials and is now being tested in combination with immune checkpoint blockade. Combination therapies offer the best chance of

Externí odkaz: https://doaj.org/article/45333d28906e4c79a697ecb02c401857

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Akademický článek

Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

Background Rectal cancers show a highly varied response to neoadjuvant radiotherapy/chemoradiation (RT/CRT) and the impact of the tumor immune microenvironment on this response is poorly understood. Current clinical tumor regression grading systems a

Externí odkaz: https://doaj.org/article/48882b43944f4a79aa411b08dcce06cb

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Akademický článek

Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)

Background Multiple myeloma (MM) remains an incurable disease and oncolytic viruses offer a well-tolerated addition to the therapeutic arsenal. Oncolytic reovirus has progressed to phase I clinical trials and its direct lytic potential has been exten

Externí odkaz: https://doaj.org/article/db50054d7a414d2980de99757b9e839e

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Akademický článek

Oncolytic Viruses: Do They Have a Role in Anti-Cancer Therapy?

Autor: Robin J Prestwich, Fiona Errington, Kevin J. Harrington, Hardev S. Pandha, Peter Selby, Alan Melcher

Publikováno v: Clinical Medicine Insights: Oncology, Vol 2 (2008)

Oncolytic viruses are replication competent, tumor selective and lyse cancer cells. Their potential for anti-cancer therapy is based upon the concept that selective intratumoral replication will produce a potent anti-tumor effect and possibly bystand

Externí odkaz: https://doaj.org/article/79936686236f41d9b2664095aa5a4698

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