Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Fiona E, McCann"'
Autor:
Thomas B. Layton, Lynn Williams, Huw Colin-York, Fiona E. McCann, Marisa Cabrita, Marc Feldmann, Cameron Brown, Weilin Xie, Marco Fritzsche, Dominic Furniss, Jagdeep Nanchahal
Publikováno v:
Biology Open, Vol 9, Iss 3 (2020)
Mechanical force is a fundamental regulator of cell phenotype. Myofibroblasts are central mediators of fibrosis, a major unmet clinical need characterised by the deposition of excessive matrix proteins. Traction forces of myofibroblasts play a key ro
Externí odkaz:
https://doaj.org/article/d52f174eb2eb475380dde359b74ce9ac
Autor:
Jagdeep Nanchahal, Catherine Ball, Dominique Davidson, Lynn Williams, William Sones, Fiona E. McCann, Marisa Cabrita, Jennifer Swettenham, Neil J. Cahoon, Bethan Copsey, E. Anne Francis, Peter C. Taylor, Joanna Black, Vicki S. Barber, Susan Dutton, Marc Feldmann, Sarah E. Lamb
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 282-288 (2018)
Background: Dupuytren's disease is a common fibrotic condition of the hand that causes irreversible flexion contractures of the fingers, with no approved therapy for early stage disease. Our previous analysis of surgically-excised tissue defined tumo
Externí odkaz:
https://doaj.org/article/642d6f5c9ade41d397e418855af2af22
Autor:
Natalya M. Kogan, Yarden Lavi, Louise M. Topping, Richard. O. Williams, Fiona E. McCann, Zhanna Yekhtin, Marc Feldmann, Ruth Gallily, Raphael Mechoulam
Publikováno v:
Molecules, Vol 26, Iss 18, p 5601 (2021)
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to p
Externí odkaz:
https://doaj.org/article/a6ffb15a4ba14101a91c716db021ac58
Autor:
Lorena Zuliani-Alvarez, Anna M. Marzeda, Claire Deligne, Anja Schwenzer, Fiona E. McCann, Brian D. Marsden, Anna M. Piccinini, Kim S. Midwood
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code
Externí odkaz:
https://doaj.org/article/280b5571ad664b09ab67b12a008edf59
Autor:
Dominique Davidson, Lorraine Harry, Lynn M. Williams, Chris Bainbridge, Manu Sood, Weilin Xie, Hai Fang, Bogdan Knezevic, Marisa Cabrita, Michael Sundstrӧm, Julian C. Knight, Sarah Bonham, Fiona E. McCann, Adam P. Cribbs, Roman Fischer, Jagdeep Nanchahal, Nan Yang, Leenart M Steenbeek, Thomas B. Layton, Marc Feldmann, Mingjun Zhang, David Warwick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fibrosis remains a major unmet medical need as therapeutic targets discovered in animal models have failed to translate. A major challenge for identifying novel targets is the limited availability of early-stage human disease tissue. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08d19dd786c0c58af7dc421950c39de
https://doi.org/10.1073/pnas.2004281117
https://doi.org/10.1073/pnas.2004281117
Autor:
Louise M. Topping, Yarden Lavi, Zhanna Yekhtin, Marc Feldmann, Natalya M. Kogan, Fiona E. McCann, Raphael Mechoulam, Richard O. Williams, Ruth Gallily
Publikováno v:
Molecules
Volume 26
Issue 18
Molecules, Vol 26, Iss 5601, p 5601 (2021)
Volume 26
Issue 18
Molecules, Vol 26, Iss 5601, p 5601 (2021)
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3ad5fb9e5bd4c10431d49b10bc0766
Autor:
Stylianos Panagoutsos, Ploumis Pasadakis, Thomas L. Nickolas, Vassilis Vargemezis, William D. Fraser, Fiona E. McCann, Michael Pazianas, Pascale Khairallah
Publikováno v:
Nephrology Dialysis Transplantation. 36
Background and Aims End stage kidney disease (ESKD) is associated with a malnutrition-inflammation complex that results in several endocrine, musculoskeletal, and metabolic abnormalities. Despite the known resultant derangements from this process, fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83e3ff67d5d296f0aa46629bf9d0146b
https://doi.org/10.1093/ndt/gfab096.0016
https://doi.org/10.1093/ndt/gfab096.0016
Autor:
Dominic Furniss, Marc Feldmann, Weilin Xie, Jagdeep Nanchahal, M Ng, Fiona E. McCann, Thomas B. Layton, Mingjun Zhang, Stephen N. Sansom, Marco Fritzsche, Lynn M. Williams, Marisa Cabrita, Huw Colin-York
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Fibrotic disorders are some of the most devastating and poorly treated conditions in developed nations, yet effective therapeutics are not identified for many of them. A major barrier for the identification of targets and successful clinical translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559226e09164015d21fecc9fff7a7933
https://pubmed.ncbi.nlm.nih.gov/32488016
https://pubmed.ncbi.nlm.nih.gov/32488016
Autor:
Dominic Furniss, Huw Colin-York, Fiona E. McCann, Mingjun Zhang, Marisa Cabrita, Thomas B. Layton, M Ng, Stephen N. Sansom, Jagdeep Nanchahal, Marco Fritzsche, Lynn M. Williams, Weilin Xie, Marc Feldmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Fibrotic disorders are some of the most devastating and poorly treated conditions in developed nations, yet effective therapeutics are not identified for many of them. A major barrier for the identification of targets and successful clinical translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e03342b261cac8da5c4cb3369b56f58
https://doi.org/10.1038/s41467-020-16264-y
https://doi.org/10.1038/s41467-020-16264-y
Autor:
Marco Fritzsche, Kim S. Midwood, Marc Feldmann, Lynn M. Williams, Thomas B. Layton, Ana Isabel Espirito Santo, Jagdeep Nanchahal, Huw Colin-York, Marisa Cabrita, Weilin Xie, Fiona E. McCann, David Izadi
Publikováno v:
Science Advances
IL-33 mediates cross-talk between immune and stromal cells in localized fibrosis.
Dissecting the molecular landscape of fibrotic disease, a major unmet need, will inform the development of novel treatment strategies to target disease progression
Dissecting the molecular landscape of fibrotic disease, a major unmet need, will inform the development of novel treatment strategies to target disease progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005f81697675cac5b5721befd49890a6
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