Výsledky vyhledávání - "Fiona D. Zeeb"

Effects of exposure to chronic uncertainty and a sensitizing regimen of amphetamine injections on locomotion, decision-making, and dopamine receptors in rats

Autor: Fiona D. Zeeb, Paul J. Fletcher, Victoria Fugariu, José N. Nobrega, Martin Zack

Publikováno v: Neuropsychopharmacology

Gambling disorder (GD) is a behavioral addiction that may be linked to alterations in dopamine (DA) systems. Gambling involves chronic exposure to uncertain reward, which can sensitize the activity of DA systems. Here we explored how combinations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d09d1716942c6f6b554ff600cac01a0
https://doi.org/10.1038/s41386-020-0599-x

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Differential Effects of Lipopolysaccharide on Cognition, Corticosterone and Cytokines in Socially-Housed vs Isolated Male Rats

Autor: Brittney Russell, Kelly M. Hrelja, Wendy K. Adams, Fiona D. Zeeb, Matthew D. Taves, Sukhbir Kaur, Kiran K. Soma, Catharine A. Winstanley

Publikováno v: SSRN Electronic Journal.

Social isolation is an established risk factor for mental illness and impaired immune function. Evidence suggests that neuroinflammatory processes contribute to mental illness, possibly via cytokine-induced modulation of neural activity. We examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff26e7cea093fb4d0158b2bc2a69fbd4
https://doi.org/10.2139/ssrn.4011647

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Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task

Autor: Sandy Thevarkunnel, Leo B. Silenieks, Cam MacMillan, Guy A. Higgins, Fiona D. Zeeb

Publikováno v: Behavioural Brain Research. 348:201-210

Previous studies demonstrated that NMDA receptor antagonists such as dizocilpine (MK801) and the GluN2B NMDA antagonist Ro 63–1908 promote impulsive action (motor impulsivity). The effects of these treatments on impulsive choice and decision-making

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8250bf57e3d13a0b566d91404d778872
https://doi.org/10.1016/j.bbr.2018.04.028

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Dissociable effects of systemic and orbitofrontal administration of adrenoceptor antagonists on yohimbine-induced motor impulsivity

Autor: Michael M. Barrus, Catharine A. Winstanley, Paul J. Cocker, Wendy K. Adams, Fiona D. Zeeb, James Benoit

Publikováno v: Behavioural Brain Research. 328:19-27

The α2-adrenoceptor antagonist, yohimbine, is commonly used as a pharmacological stressor. Its behavioural effects are typically attributed to elevated noradrenaline release via blockade of central, inhibitory autoreceptors. We have previously repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb34e7dfbe6e458f2987faa41fa4f68c
https://doi.org/10.1016/j.bbr.2017.03.034

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Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate

Autor: Fiona D. Zeeb, Ashlie D. Soko, Paul J. Fletcher, Guy A. Higgins, Caleb J. Browne

Publikováno v: Psychopharmacology. 234:889-902

These experiments examined the effects of selective 5-HT1A, 5-HT2A and 5-HT2C receptor ligands on responding for a conditioned reinforcer (CRf). Effects of these ligands were measured under basal conditions and following elevated dopamine (DA) activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aef60742ad08391be86cebc6c1cdb5a3
https://doi.org/10.1007/s00213-017-4529-5

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Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment

Autor: Guy A. Higgins, Fiona D. Zeeb, Julia Sevo, Leo B. Silenieks, Sandy Thevarkunnel, Cam MacMillan

Publikováno v: Behavioural Brain Research. 311:1-14

NMDA GluN2B (NR2B) subtype selective antagonists are currently in clinical development for a variety of indications, including major depression. We previously reported the selective NMDA GluN2B antagonists Ro 63-1908 and traxoprodil, increase prematu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4634d479a5deb97fe9cede31ee4e901e
https://doi.org/10.1016/j.bbr.2016.05.025

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Responding for a conditioned reinforcer or unconditioned sensory reinforcer in mice: interactions with environmental enrichment, social isolation, and monoamine reuptake inhibitors

Autor: Fiona D. Zeeb, Paul J. Fletcher, Caleb J. Browne

Publikováno v: Psychopharmacology. 233:983-993

Environmental factors influence the etiology of many psychiatric disorders. Likewise, environmental factors can alter processes central to motivation. Therefore, motivational deficits present in many disorders may be influenced by early life environm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3a1ccd1d8109b3b169329ae9fb6f94
https://doi.org/10.1007/s00213-015-4178-5

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The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine

Autor: Guy A. Higgins, Fiona D. Zeeb, Paul J. Fletcher

Publikováno v: ACS Chemical Neuroscience. 6:1231-1240

Lorcaserin, a serotonin (5-hydroxytryptamine, 5-HT) 2C receptor agonist, was recently approved for the treatment of obesity. We previously suggested that 5-HT2C receptor agonists affect reward processes and reduce the rewarding effects of drugs of ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39e514300500143c7f84d2849436cca
https://doi.org/10.1021/acschemneuro.5b00017

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Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder

Autor: Martin Zack, Paul J. Fletcher, Daniel C. Fisher, Zhaoxia Li, Fiona D. Zeeb

Publikováno v: Journal of psychiatryneuroscience : JPN. 42(6)

Background: An animal model of gambling disorder, previously known as pathological gambling, could advance our understanding of the disorder and help with treatment development. We hypothesized that repeated exposure to uncertainty during gambling in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0826fc0ef89e0ea3c0be8abcc85ca761
https://pubmed.ncbi.nlm.nih.gov/28832319

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