Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Fiona C. Rowan"'
Autor:
Guilherme V, de Castro, Dennis J, Worm, Grzegorz J, Grabe, Fiona C, Rowan, Lucy, Haggerty, Ana L, de la Lastra, Oana, Popescu, Sophie, Helaine, Anna, Barnard
Publikováno v:
ACS chemical biology. 17(6)
In the search for novel antimicrobial therapeutics, toxin-antitoxin (TA) modules are promising yet underexplored targets for overcoming antibiotic failure. The bacterial toxin Doc has been associated with the persistence of
Autor:
Guilherme V. de Castro, Dennis J. Worm, Grzegorz J. Grabe, Fiona C. Rowan, Lucy Haggerty, Ana L. de la Lastra, Oana Popescu, Sophie Helaine, Anna Barnard
In the search for novel antimicrobial therapeutics, toxin-antitoxin (TA) modules are promising yet underexplored targets for overcoming antibiotic failure. The bacterial toxin Doc has been associated with the persistence of Salmonella in macrophages,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9405fd1500f3004ad7174b519a9fdaa
http://hdl.handle.net/10044/1/97563
http://hdl.handle.net/10044/1/97563
Autor:
Andrew J. Thompson, Julian Blagg, Meirion Richards, Rachel Ann Bibby, Fiona C. Rowan, Richard Bayliss
Publikováno v:
ACS Chemical Biology
Most protein kinases are regulated through activation loop phosphorylation, but the contributions of individual sites are largely unresolved due to insufficient control over sample phosphorylation. Aurora-A is a mitotic Ser/Thr protein kinase that ha
Autor:
Kwai-Ming J. Cheung, Joanne E. Baxter, Andrew M. Fry, K. Boxall, Savade Solanki, Swen Hoelder, Tara Hardy, Paolo Innocenti, Lisa Pickard, Fiona C. Rowan, Corine Mas-Droux, G.W. Aherne, Maura Westlake, Richard Bayliss, Sharon Yeoh
Publikováno v:
Journal of Medicinal Chemistry. 55:3228-3241
We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. Structure based design led to aminopyridine (R)-21, a potent a
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e103935 (2014)
PLoS ONE, Vol 9, Iss 8, p e103935 (2014)
The ability to obtain a homogeneous sample of protein is invaluable when studying the effect of alterations such as post-translational modifications (PTMs). Selective functionalization of a protein to investigate the effect of PTMs on its structure o