Výsledky vyhledávání - "Fiona C. Ringholz"

Resolvin D1 regulates epithelial ion transport and inflammation in cystic fibrosis airways

Autor: Gerard Higgins, Isabelle Sermet-Gaudelus, Paul McNally, Monika Hollenhorst, Ahmad Moukachar, Aurélie Hatton, Coral Fustero-Torre, Valerie Urbach, Fiona C. Ringholz, Brian J. Harvey, Ali Sassi

Publikováno v: Journal of Cystic Fibrosis
Journal of Cystic Fibrosis, Elsevier, 2018, 17 (5), pp.607-615. ⟨10.1016/j.jcf.2017.11.017⟩

Background Cystic Fibrosis (CF) lung disease is characterised by dysregulated ion transport that promotes chronic bacterial infection and inflammation. The impact of the specialised pro-resolution mediator resolvin D1 (RvD1) on airway surface liquid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906a43bd74b06e5f915d4e2098e7a4ba
https://doi.org/10.1016/j.jcf.2017.11.017

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Specialized Pro-resolution Mediators in Cystic Fibrosis Lung Disease

Autor: Fiona C. Ringholz (7959560)

CF is caused by a mutation in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) and results in airway surface liquid (ASL) dehydration, impaired muco-ciliary clearance, chronic pulmonary infection and inflammation leading to progressive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5078bae12469d61bc9cf439dfb560080

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Pulmonary aspiration in preschool children with cystic fibrosis

Autor: Donna Clarke, P Mc Nally, Peter Greally, Fiona C. Ringholz, Des W. Cox, Michael P. McDermott, I Gorman, Barry Linnane

Publikováno v: Respiratory Research
Respiratory Research, Vol 19, Iss 1, Pp 1-3 (2018)

Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160d90468a9bffc6753fa466d462b580
https://pubmed.ncbi.nlm.nih.gov/30558606

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Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis

Autor: Fiona C. Ringholz, Paul Buchanan, Brian J. Harvey, Michael P. McDermott, Paul McNally, Donna Clarke, Valerie Urbach, Barry Linnane, Roisin G Millar

Publikováno v: European Respiratory Journal
European Respiratory Journal, European Respiratory Society, 2014, 44 (2), pp.394-404. ⟨10.1183/09031936.00106013⟩

Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance, persistent bacterial infection and neutrophilic inflammation. Lipoxin A4 (LXA4) initiates the active resolution of inflammation and promotes airway surface hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679837c11d74706847bdf4d3f3c655cb
https://pubmed.ncbi.nlm.nih.gov/24696116

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Managing end stage lung disease in children

Autor: Paul McNally, Fiona C. Ringholz, Mary Devins

Publikováno v: Paediatric respiratory reviews. 15(1)

Over the course of a career most physicians will manage only a handful of children through End Stage Lung Disease. Nonetheless, the approach of the physician to this challenge will have a profound impact on the children and families they encounter. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee7ba6380bb4b8157643f83553abf3b
https://pubmed.ncbi.nlm.nih.gov/23948571

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THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE

Autor: Fiona C. Ringholz, Valerie Urbach, Gerard Higgins, Paul Buchanan

Publikováno v: Computational and Structural Biotechnology Journal, Vol 6, Iss 7 (2013)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Elsevier, 2013, 6 (7), pp.e201303018. ⟨10.5936/csbj.201303018⟩

In Cystic Fibrosis (CF), mutations of the CFTR gene result in defective Cl− secretion and Na+ hyperabsorption by epithelia which leads to airway lumen dehydration and mucus plugging and favours chronic bacterial colonization, persistent inflammatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4bdf953c5abb8a346f7d08ea31d6db
http://www.sciencedirect.com/science/article/pii/S2001037014601276

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