Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Fiona C McKay"'
Autor:
Fiona C McKay, Edwin Hoe, Grant Parnell, Prudence Gatt, Stephen D Schibeci, Graeme J Stewart, David R Booth
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77508 (2013)
The IL7Rα gene is unequivocally associated with susceptibility to multiple sclerosis (MS). Haplotype 2 (Hap 2) confers protection from MS, and T cells and dendritic cells (DCs) of Hap 2 exhibit reduced splicing of exon 6, resulting in production of
Externí odkaz:
https://doaj.org/article/31ed427fd32c4fc3be012982a02f12e8
Autor:
Carlos Riveros, Drew Mellor, Kaushal S Gandhi, Fiona C McKay, Mathew B Cox, Regina Berretta, S Yahya Vaezpour, Mario Inostroza-Ponta, Simon A Broadley, Robert N Heard, Stephen Vucic, Graeme J Stewart, David W Williams, Rodney J Scott, Jeanette Lechner-Scott, David R Booth, Pablo Moscato, ANZgene Multiple Sclerosis Genetics Consortium
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14176 (2010)
BackgroundSeveral lines of evidence suggest that transcription factors are involved in the pathogenesis of Multiple Sclerosis (MS) but complete mapping of the whole network has been elusive. One of the reasons is that there are several clinical subty
Externí odkaz:
https://doaj.org/article/57cf07fc99e548b88dcd763073a08da1
Autor:
Kaushal S Gandhi, Fiona C McKay, Eve Diefenbach, Ben Crossett, Stephen D Schibeci, Robert N Heard, Graeme J Stewart, David R Booth, Jonathan W Arthur
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10484 (2010)
Interferon beta (IFNbeta) is the most common immunomodulatory treatment for relapsing-remitting multiple sclerosis (RRMS). However, some patients fail to respond to treatment. In this study, we identified putative clinical response markers in the ser
Externí odkaz:
https://doaj.org/article/8c6ea329e8b54c66ae614ed5dc5195ca
Autor:
David Brown, Prudence N. Gatt, Graeme J. Stewart, Steve Vucic, Fiona C. McKay, Christopher Liddle, Samantha P L Law, Scott N. Byrne, Prue H. Hart, David R. Booth, Stephen D. Schibeci, Grant P Parnell
Publikováno v:
Genes and Immunity
Although genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form doe
Autor:
Monica A. I. Basuki, David Brown, Nicole Fewings, Grant P Parnell, David R. Booth, Stephen D. Schibeci, Graeme J. Stewart, Sanjay Swaminathan, Bruce V. Taylor, Yuan Zhou, Ali Afrasiabi, Fiona C. McKay, Ramya Chandramohan
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-13 (2019)
Genome Medicine
Genome Medicine
Background Genome wide association studies have identified > 200 susceptibility loci accounting for much of the heritability of multiple sclerosis (MS). Epstein-Barr virus (EBV), a memory B cell tropic virus, has been identified as necessary but not
Autor:
Fiona C. McKay, Golo Ahlenstiel, Scott A. Read, Gaitan Fabrice Njiomegnie, Jacob George, Nicole Fewings
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 1030, p 1030 (2020)
Journal of Clinical Medicine
Journal of Clinical Medicine
Hepatitis C virus (HCV) infection develops into chronic hepatitis in over two-thirds of acute infections. While current treatments with direct-acting antivirals (DAAs) achieve HCV eradication in >95% of cases, no vaccine is available and re-infection
Autor:
Clara P. Manrique, Fiona C. McKay, Prudence N. Gatt, Steve Vucic, Graeme J. Stewart, Nicole Fewings, Therese Burke, Monica A. I. Basuki, David R. Booth, Stephen D. Schibeci, Allan G. Kermode, Marzena J. Fabis-Pedrini, Dorothee Nickles, Anita Goldinger, Grant P Parnell, J. Edwards, Sergio E. Baranzini, Jacob L. McCauley
Publikováno v:
Journal of Autoimmunity. 78:57-69
Multiple Sclerosis (MS) is a neurological condition driven in part by immune cells from the peripheral circulation, the targets for current successful therapies. The autoimmune and MS risk gene ZMIZ1 is underexpressed in blood in people with MS. We s
Autor:
Prudence N. Gatt, Sergio E. Baranzini, Allan G. Kermode, Jacob L. McCauley, Fiona C. McKay, Nicole Fewings, David R. Booth, Dorothee Nickles, Stephen D. Schibeci, Graeme J. Stewart, Clara P. Manrique, Therese Burke, Anita Goldinger, J. Edwards, Steve Vucic, Grant P Parnell, Marzena J. Fabis-Pedrini, Monica A. I. Basuki
Publikováno v:
Data in Brief
Data in Brief, Vol 11, Iss C, Pp 364-370 (2017)
Data in Brief, Vol 11, Iss C, Pp 364-370 (2017)
The data presented in this article are related to the research article entitled “The autoimmune risk gene ZMIZ1 is a vitamin D responsived marker of a molecular phenotype of multiple sclerosis” Fewings et al. (2017) [1]. Here we identify the set
Autor:
Vilija Jokubaitis, Manuel Comabella, Vittorio Martinelli, Fiona C. McKay, Filippo Martinelli Boneschi, Malgorzata Krupa, Giuseppe Liberatore, Jeannette Lechner-Scott, Vijayaprakash Suppiah, G. Comi, Mark Slee, Allan G. Kermode, Xavier Montalban, C King, Max Moldovan, Bruce V. Taylor, Melissa Sorosina, Marzena J. Fabis-Pedrini, Sunny Malhotra, Sunil Mahurkar, Ferdinando Clarelli, Koen Vandenbroeck, Prudence N. Gatt, Alfredo Antigüedad
Publikováno v:
The Pharmacogenomics Journal. 17:312-318
Up to 50% of multiple sclerosis (MS) patients do not respond to interferon-beta (IFN-β) treatment and determination of response requires lengthy clinical follow-up of up to 2 years. Response predictive genetic markers would significantly improve dis
Publikováno v:
Annals of the Rheumatic Diseases. 79:576.2-576
Background:Natural Killer (NK) cells are an innate immune cell type that has somewhat been overlooked in the context of systemic lupus erythematosus (SLE). SLE patients display a reduced number of NK cells with an activated phenotype and increased ca