Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Fiona Broughton-Pipkin"'
Autor:
Valgerdur Steinthorsdottir, Ralph McGinnis, Nicholas O. Williams, Lilja Stefansdottir, Gudmar Thorleifsson, Scott Shooter, João Fadista, Jon K. Sigurdsson, Kirsi M. Auro, Galina Berezina, Maria-Carolina Borges, Suzannah Bumpstead, Jonas Bybjerg-Grauholm, Irina Colgiu, Vivien A. Dolby, Frank Dudbridge, Stephanie M. Engel, Christopher S. Franklin, Michael L. Frigge, Yr Frisbaek, Reynir T. Geirsson, Frank Geller, Solveig Gretarsdottir, Daniel F. Gudbjartsson, Quaker Harmon, David Michael Hougaard, Tatyana Hegay, Anna Helgadottir, Sigrun Hjartardottir, Tiina Jääskeläinen, Hrefna Johannsdottir, Ingileif Jonsdottir, Thorhildur Juliusdottir, Noor Kalsheker, Abdumadjit Kasimov, John P. Kemp, Katja Kivinen, Kari Klungsøyr, Wai K. Lee, Mads Melbye, Zosia Miedzybrodska, Ashley Moffett, Dilbar Najmutdinova, Firuza Nishanova, Thorunn Olafsdottir, Markus Perola, Fiona Broughton Pipkin, Lucilla Poston, Gordon Prescott, Saedis Saevarsdottir, Damilya Salimbayeva, Paula Juliet Scaife, Line Skotte, Eleonora Staines-Urias, Olafur A. Stefansson, Karina Meden Sørensen, Liv Cecilie Vestrheim Thomsen, Vinicius Tragante, Lill Trogstad, Nigel A. B. Simpson, FINNPEC Consortium, GOPEC Consortium, Tamara Aripova, Juan P. Casas, Anna F. Dominiczak, James J. Walker, Unnur Thorsteinsdottir, Ann-Charlotte Iversen, Bjarke Feenstra, Deborah A. Lawlor, Heather Allison Boyd, Per Magnus, Hannele Laivuori, Nodira Zakhidova, Gulnara Svyatova, Kari Stefansson, Linda Morgan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that geneti
Externí odkaz:
https://doaj.org/article/54b589a97a1246bc8db4f581846322e3
Autor:
Hiten D. Mistry, Melissa V. Hott Ogalde, Fiona Broughton Pipkin, Geneviève Escher, Lesia O. Kurlak
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory. We hypothesized that
Externí odkaz:
https://doaj.org/article/ec718fcf3b234b7c923195b600f9951a
Autor:
Hiten D. Mistry, Lesia O. Kurlak, David S. Gardner, Ole Torffvit, Alastair Hansen, Fiona Broughton Pipkin, Helena Strevens
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 13 (2019)
Background AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT, as a component of the intrarenal renin–angiotensin system. We investigated urinary AGT, as a biomarker for renin–angioten
Externí odkaz:
https://doaj.org/article/b242e4446ea743f5baa2667629c032e5
Autor:
Lesia O. Kurlak, Paula J. Scaife, Louise V. Briggs, Fiona Broughton Pipkin, David S. Gardner, Hiten D. Mistry
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3579
Volume 24
Issue 4
Pages: 3579
Trace elements such as selenium and zinc are vital components of many enzymes, including endogenous antioxidants, and can interact with each other. Women with pre-eclampsia, the hypertensive disease of pregnancy, have been reported as having changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8dba0e4bed0146e9c576783369bad3
Autor:
Opeyemi Abayomi Obilade, Alani Suleimon Akanmu, Fiona Broughton Pipkin, Bosede Bukola Afolabi
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184345 (2017)
Pregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of the expected
Externí odkaz:
https://doaj.org/article/befe2275b00a43f683bb233d3e9db348
Autor:
Fiona Broughton Pipkin, Amy Simpson, Louise V. Briggs, Carolyn J.P. Jones, David S. Gardner, Lesia O. Kurlak, Paula J. Scaife, Hiten D. Mistry
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7295, p 7295 (2021)
Volume 22
Issue 14
Scaife, P J, Simpson, A, Kurlak, L O, Briggs, L V, Gardner, D S, Pipkin, F B, Jones, C J P & Mistry, H D 2021, ' Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies ', International Journal of Molecular Sciences, vol. 22, no. 14, 7295 . https://doi.org/10.3390/ijms22147295
International Journal of Molecular Sciences, Vol 22, Iss 7295, p 7295 (2021)
Volume 22
Issue 14
Scaife, P J, Simpson, A, Kurlak, L O, Briggs, L V, Gardner, D S, Pipkin, F B, Jones, C J P & Mistry, H D 2021, ' Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies ', International Journal of Molecular Sciences, vol. 22, no. 14, 7295 . https://doi.org/10.3390/ijms22147295
Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c9473ee6405a3243e91a8da6648825
http://europepmc.org/articles/PMC8303298
http://europepmc.org/articles/PMC8303298
Autor:
Daniel P. Hay, Raheela N. Khan, Averil Y. Warren, Katrin N. Sander, Tayyba Ali, Fiona Broughton Pipkin, David A. Barrett
Publikováno v:
Placenta. 88:12-19
Introduction The function of the placental vasculature differs considerably from other systemic vascular beds of the human body. A detailed understanding of the normal placental vascular physiology is the foundation to understand perturbed conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d08f0bbe90398ceb22bc0bc7cb32789
https://doi.org/10.1016/j.placenta.2019.09.009
https://doi.org/10.1016/j.placenta.2019.09.009
Publikováno v:
Clinical Kidney Journal
Background Women with chronic kidney disease (CKD) are at increased risk of superimposed pre-eclampsia (SPE). Accurate identification of SPE is challenging. We hypothesized that specific components of the renin–angiotensin–aldosterone system (RAA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c89be3ea5eb9b9af772de7440c0e935
https://doi.org/10.1093/ckj/sfz025
https://doi.org/10.1093/ckj/sfz025
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114405 (2014)
Chorionic plate arteries (CPA) are located at the maternofetal interface where they are able to respond to local metabolic changes. Unlike many other types of vasculature, the placenta lacks nervous control and requires autoregulation for controlling
Externí odkaz:
https://doaj.org/article/24b006c4c53e4d38b3c21959ba35503c
Autor:
Catherine Martin, Barrie Hayes-Gill, Sahil Deepak, Jim G Thornton, Hanns-Ulrich Marschall, Anita Lövgren-Sandblom, Catherine Williamson, Joel S.C. Yang, William P. Fifer, Victoria Geenes, S Stone, Jenny Chambers, Pam Loughna, Fiona Broughton Pipkin, Julia Gorelik, Lucy C Chappell, Maristella Lucchini, Indu Asanka Jayawardane, Peter H. Dixon, Paul T. Seed, Tharni Vasavan, Lesia O. Kurlak
Publikováno v:
Vasavan, T, Deepak, S, Jayawardane, I A, Lucchini, M, Martin, C, Geenes, V, Yang, J, Lövgren-Sandblom, A, Seed, P T, Chambers, J, Stone, S, Kurlak, L, Dixon, P H, Marschall, H-U, Gorelik, J, Chappell, L, Loughna, P, Thornton, J, Pipkin, F B, Hayes-Gill, B, Fifer, W P & Williamson, C 2020, ' Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations ', Journal of Hepatology, vol. 0, no. 0, pp. 1-10 . https://doi.org/10.1016/j.jhep.2020.11.038
Journal of Hepatology
Journal of Hepatology
Background & Aims Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of stillbirth. This study aimed to assess the relationship between bile acid concentrations and fetal cardiac dysfunction in patients with ICP who were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db882ff06d00bfcb9df5f4514362aea0
https://kclpure.kcl.ac.uk/ws/files/147610169/Fetal_cardiac_dysfunction_in_VASAVAN_Acc24Nov2020Epub1Dec2020_GOLD_CP_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/147610169/Fetal_cardiac_dysfunction_in_VASAVAN_Acc24Nov2020Epub1Dec2020_GOLD_CP_CC_BY_.pdf
