Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fiona B Young"'
Autor:
Fiona B Young, Sonia Franciosi, Amanda Spreeuw, Yu Deng, Shaun Sanders, Natalie C M Tam, Kun Huang, Roshni R Singaraja, Weining Zhang, Nagat Bissada, Chris Kay, Michael R Hayden
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36315 (2012)
Huntingtin Interacting Protein 14 (HIP14) is a palmitoyl acyl transferase (PAT) that was first identified due to altered interaction with mutant huntingtin, the protein responsible for Huntington Disease (HD). HIP14 palmitoylates a specific set of ne
Externí odkaz:
https://doaj.org/article/5db8172525484d548ab42c775980e410
Publikováno v:
Journal of Obstetrics and Gynaecology Canada. 42:695
Objectives (1) Determine the rates of unintended pregnancy (UP) in sexually active Canadian women; (2) Examine 10-year trends in UP in Canada; (3) Identify contraceptive practices and pregnancy outcomes in women experiencing UP. Methods A national cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10ac24e8d971fe11001ad0a8b077fc7
https://doi.org/10.1016/j.jogc.2020.02.119
https://doi.org/10.1016/j.jogc.2020.02.119
Autor:
Sabrina Bergeron, Austen J. Milnerwood, Matthew P. Parsons, Michael R. Hayden, Mattia Volta, Roshni R. Singaraja, Sonia Franciosi, Fiona B. Young, Lynn A. Raymond
Publikováno v:
Proceedings of the National Academy of Sciences. 110:20296-20301
Palmitoylation of neurotransmitter receptors and associated scaffold proteins regulates their membrane association in a rapid, reversible, and activity-dependent fashion. This makes palmitoylation an attractive candidate as a key regulator of the fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b3ef2028341f42aa4c7b52ab1b99c5
https://doi.org/10.1073/pnas.1222384110
https://doi.org/10.1073/pnas.1222384110
Autor:
Amber L. Southwell, Katherine K. N. Mui, Crystal N. Doty, Liza M. Sutton, Fiona B. Young, Michael R. Hayden, Shaun S. Sanders, Weining Zhang, Sonia Franciosi, Roshni R. Singaraja, Vlad Kovalik, Mandi E. Schmidt, Stefanie L. Butland
Publikováno v:
Human Molecular Genetics. 22:452-465
Palmitoylation, the dynamic post-translational addition of the lipid, palmitate, to proteins by Asp-His-His-Cys-containing palmitoyl acyltransferase (PAT) enzymes, modulates protein function and localization and plays a key role in the nervous system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2b51de409bad8836f93c7eca3e2361
https://doi.org/10.1093/hmg/dds441
https://doi.org/10.1093/hmg/dds441
Autor:
Kun Huang, Roshni R. Singaraja, Crystal N. Doty, Junmei Wan, Michael R. Hayden, Nagat Bissada, Sonia Franciosi, R. Mark Henkelman, Shaun S. Sanders, Nicholas G. Davis, Renaldo C. Drisdel, Fiona B. Young, Jason P. Lerch, Kuljeet Vaid, Lynn A. Raymond, Rochelle M. Hines, William N. Green, Austen J. Milnerwood
Publikováno v:
Human Molecular Genetics. 20:3899-3909
Huntingtin interacting protein 14 (HIP14, ZDHHC17) is a huntingtin (HTT) interacting protein with palmitoyl transferase activity. In order to interrogate the function of Hip14, we generated mice with disruption in their Hip14 gene. Hip14-/- mice disp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb4500e3eb9b4f07ce06518d74c7530
https://doi.org/10.1093/hmg/ddr308
https://doi.org/10.1093/hmg/ddr308
Publikováno v:
Stroke. 36:2187-2192
Background and Purpose— Acute stroke trials typically use disability scales as their primary end point. Neurologic impairment scales such as the National Institutes of Health Stroke Scale (NIHSS) are possibly more sensitive to change in patient sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6b35f92640cbbe4618256553d285de
https://doi.org/10.1161/01.str.0000181089.41324.70
https://doi.org/10.1161/01.str.0000181089.41324.70
Publikováno v:
Clinical and investigative medicine. Medecine clinique et experimentale. 36(4)
Enhancing clinician-investigator (CI) training at Canadian medical schools is urgently needed to bolster the dwindling work force of medical professionals carrying out patient-oriented research in a wide array of medical fields. The purpose of this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc43f967d3965320935d23366b1b37be
https://pubmed.ncbi.nlm.nih.gov/23906488
https://pubmed.ncbi.nlm.nih.gov/23906488
Autor:
Chris Kay, Shaun S. Sanders, Yu Deng, Michael R. Hayden, Sonia Franciosi, Amanda Spreeuw, Nagat Bissada, Natalie C. M. Tam, Roshni R. Singaraja, Fiona B. Young, Kun Huang, Weining Zhang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 5, p e36315 (2012)
PLoS ONE, Vol 7, Iss 5, p e36315 (2012)
Huntingtin Interacting Protein 14 (HIP14) is a palmitoyl acyl transferase (PAT) that was first identified due to altered interaction with mutant huntingtin, the protein responsible for Huntington Disease (HD). HIP14 palmitoylates a specific set of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205c9d72c73884e77cefeb4d46a64b64
https://pubmed.ncbi.nlm.nih.gov/22649491
https://pubmed.ncbi.nlm.nih.gov/22649491
Publikováno v:
Progress in neurobiology. 97(2)
Post-translational modification of proteins by the lipid palmitate is critical for protein localization and function. Palmitoylation is regulated by the opposing enzymes palmitoyl acyltransferases (PATs) and acyl protein thioesterases, which add and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88a4b2c7631fe3116b7360efee62a7c
https://pubmed.ncbi.nlm.nih.gov/22155432
https://pubmed.ncbi.nlm.nih.gov/22155432
Autor:
Shaun S. Sanders, Fiona B. Young, Lili Liu, Kun Huang, Michael R. Hayden, Liza M. Sutton, Roshni R. Singaraja, Nicholas G. Davis, Alaa El-Husseini, Jeffrey B. Carroll, Rujun Kang, Junmei Wan
Publikováno v:
Human molecular genetics. 20(17)
Huntington disease (HD) is caused by polyglutamine expansion in the huntingtin (HTT) protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing palmitoyl acyl transferases (PATs), binds to HTT and robustly palmitoylates HTT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eb458107b0037f6014cfdcc72ee77f
https://pubmed.ncbi.nlm.nih.gov/21636527
https://pubmed.ncbi.nlm.nih.gov/21636527