Direct pro-inflammatory effects of prorenin on microglia.

Autor: Peng Shi, Justin L Grobe, Fiona A Desland, Guannan Zhou, Xiao Z Shen, Zhiying Shan, Meng Liu, Mohan K Raizada, Colin Sumners

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e92937 (2014)

Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of th

Externí odkaz: https://doaj.org/article/d93d21cf559d4c7b9352cb6f4675f0a3

Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats

Autor: Jennifer L. Bizon, Adam P. Mecca, Phillip F. Ritucci-Chinni, David Greenstein, Fiona A. Desland, Colin Sumners, Cristina Bañuelos, Mary K. Reinhard, Robert W. Regenhardt, Jacob A. Ludin

Publikováno v: Experimental Physiology. 99:442-453

New Findings What is the central question of this study? Activation of angiotensin-converting enzyme 2, resulting in production of angiotensin-(1–7) and stimulation of its receptor, Mas, exerts beneficial actions in a number cardiovascular diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::880a198c9d91fe72553638ed3affaa9e
https://doi.org/10.1113/expphysiol.2013.075242

The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke

Autor: Vermali Rodriguez, Jason P. Joseph, Fiona A. Desland, U. Muscha Steckelings, David J. Pioquinto, Douglas M. Bennion, Michael J. Katovich, Robert W. Regenhardt, Colin Sumners, Neal A. Patel, Thomas Unger, Adam P. Mecca

Publikováno v: Joseph, J P, Mecca, A P, Regenhardt, R W, Bennion, D M, Rodríguez, V, Desland, F, Patel, N A, Pioquinto, D J, Unger, T, Katovich, M J, Steckelings, U M & Sumners, C 2014, ' The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke ', Neuropharmacology, vol. 81, pp. 134–141 . https://doi.org/10.1016/j.neuropharm.2014.01.044
Neuropharmacology, 81, 134-141. Elsevier Science

Evidence indicates that angiotensin II type 2 receptors (AT2R) exert cerebroprotective actions during stroke. A selective non-peptide AT2R agonist, Compound 21 (C21), has been shown to exert beneficial effects in models of cardiac and renal disease,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f022cbbf6e750f904b5e528fa7d810
https://portal.findresearcher.sdu.dk/da/publications/3c0ebe23-fc09-43f0-912c-17b7c2b1dacd

The NorR Regulon Is Critical for Vibrio cholerae Resistance to Nitric Oxide and Sustained Colonization of the Intestines

Autor: Amanda J. Hay, Fiona A. Desland, Andrew M. Stern, Juan Zhang, Zengtao Zhong, Zhi Liu, Jun Zhu

Publikováno v: mBio, Vol 3, Iss 2 (2012)
mBio

Vibrio cholerae, the cause of an often fatal infectious diarrhea, remains a large global public health threat. Little is known about the challenges V. cholerae encounters during colonization of the intestines, which genes are important for overcoming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68df1eeaf7d7731d3bba4d525224b7d
https://journals.asm.org/doi/10.1128/mBio.00013-12

Direct Pro-Inflammatory Effects of Prorenin on Microglia

Autor: Xiao Z. Shen, Mohan K. Raizada, Colin Sumners, Fiona A. Desland, Guannan Zhou, Zhiying Shan, Justin L. Grobe, Peng Shi, Meng Liu

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e92937 (2014)
PLoS ONE

Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7479c863848716651445a492a146002c
https://doi.org/10.1371/journal.pone.0092937