Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Fiona, Simpkins"'
Autor:
Haineng Xu, Sarah B. Gitto, Gwo-Yaw Ho, Sergey Medvedev, Kristy Shield-Artin, Hyoung Kim, Sally Beard, Yasuto Kinose, Xiaolei Wang, Holly E. Barker, Gayanie Ratnayake, Wei-Ting Hwang, Ryan J. Hansen, Bryan Strouse, Snezana Milutinovic, Christian Hassig, Matthew J. Wakefield, Cassandra J. Vandenberg, Clare L. Scott, Fiona Simpkins
Publikováno v:
iScience, Vol 27, Iss 7, Pp 109978- (2024)
Summary: High-grade serous ovarian cancers (HGSOCs) with homologous recombination deficiency (HRD) are initially responsive to poly (ADP-ribose) polymerase inhibitors (PARPi), but resistance ultimately emerges. HGSOC with CCNE1 amplification (CCNE1am
Externí odkaz:
https://doaj.org/article/1ed5cdda17844d2e8fc282a3b801056b
Autor:
Fiona Simpkins
Publikováno v:
Textes & Contextes, Iss 18-2 (2023)
The downward spiral of Scottish Labour’s electoral scores since the introduction of devolution to Scotland has led to a long period of soul-searching as it has questioned its organisation, ideology and identity. An array of factors has played into
Externí odkaz:
https://doaj.org/article/2e1c836d50d741e0a264d2be22906a39
Autor:
Stéphanie Bory, Fiona Simpkins
Publikováno v:
Revue Française de Civilisation Britannique, Vol 27, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/c4a454c76ab04a99accdd7ee3273126c
Autor:
Hyoung Kim, Haineng Xu, Erin George, Dorothy Hallberg, Sushil Kumar, Veena Jagannathan, Sergey Medvedev, Yasuto Kinose, Kyle Devins, Priyanka Verma, Kevin Ly, Yifan Wang, Roger A. Greenberg, Lauren Schwartz, Neil Johnson, Robert B. Scharpf, Gordon B. Mills, Rugang Zhang, Victor E. Velculescu, Eric J. Brown, Fiona Simpkins
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Patients with ovarium cancer frequently develop resistance to platinum chemotherapy and PARP inhibitors (PARPi). Here, the authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PARPi and platinum resistant
Externí odkaz:
https://doaj.org/article/cc35bbdbfeb9477db7745da1954cd683
Autor:
Haineng Xu, Erin George, Yasuto Kinose, Hyoung Kim, Jennifer B. Shah, Jasmine D. Peake, Benjamin Ferman, Sergey Medvedev, Thomas Murtha, Carter J. Barger, Kyle M. Devins, Kurt D’Andrea, Bradley Wubbenhorst, Lauren E. Schwartz, Wei-Ting Hwang, Gordon B. Mills, Katherine L. Nathanson, Adam R. Karpf, Ronny Drapkin, Eric J. Brown, Fiona Simpkins
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 9, Pp 100394- (2021)
Summary: CCNE1-amplified ovarian cancers (OVCAs) and endometrial cancers (EMCAs) are associated with platinum resistance and poor survival, representing a clinically unmet need. We hypothesized that dysregulated cell-cycle progression promoted by CCN
Externí odkaz:
https://doaj.org/article/317f0b4f67b94645ac9dda7eac42892d
Autor:
Dimitrios, Nasioudis, Nawar A, Latif, Emily M, Ko, Lori, Cory, Sarah H, Kim, Fiona, Simpkins, Mark A, Morgan, Robert L, Giuntoli
Publikováno v:
Gynecologic Oncology. 169:41-46
Investigate outcomes for advanced stage epithelial ovarian cancer (EOC) patients based on facility-level utilization of neoadjuvant chemotherapy (NACT).Stage III-IV EOC patients diagnosed between 2010 and 2016 were identified in the National Cancer D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462e6d75667fc1c18cd0fe3e557aeb8c
https://doi.org/10.1016/j.ygyno.2022.10.025
https://doi.org/10.1016/j.ygyno.2022.10.025
Autor:
Fiona Simpkins
Publikováno v:
Revue Française de Civilisation Britannique, Vol 25, Iss 3 (2020)
While “ getting Brexit done” featured at the heart of the UK Conservative 2019 general election campaign, it was clear that a similar strategy was never going to function in Scotland where 62% voted Remain in 2016. Neither could the Conservatives
Externí odkaz:
https://doaj.org/article/be3345343b924bbabe5b3a3735aab8b6
Autor:
Stefano Pierini, Janos L. Tanyi, Fiona Simpkins, Erin George, Mireia Uribe-Herranz, Ronny Drapkin, Robert Burger, Mark A. Morgan, Andrea Facciabene
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Granulosa cell tumors (GCT) are rare ovarian malignancies. Due to the lack of effective treatment in late relapse, there is a clear unmet need for novel therapies. Forkhead Box L2 (FOXL2) is a protein mainly expressed in granulosa cells (GC) and ther
Externí odkaz:
https://doaj.org/article/3ee8feab99b74b3781439e0dd4109565
Autor:
Sergey Karakashev, Hengrui Zhu, Yuhki Yokoyama, Bo Zhao, Nail Fatkhutdinov, Andrew V. Kossenkov, Andrew J. Wilson, Fiona Simpkins, David Speicher, Dineo Khabele, Benjamin G. Bitler, Rugang Zhang
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3398-3405 (2017)
Summary: PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors. Here, we show the synergy of BET bromodomain inhibition with PARP inhibition in BRCA-pr
Externí odkaz:
https://doaj.org/article/8f781436fa4e4979a645ce5bfdc70225
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 3, Pp 304-318 (2017)
Abstract The angiogenic factor, VEGFA, is a therapeutic target in ovarian cancer (OVCA). VEGFA can also stimulate stem‐like cells in certain cancers, but mechanisms thereof are poorly understood. Here, we show that VEGFA mediates stem cell actions
Externí odkaz:
https://doaj.org/article/0f1b4fb2289b48ca8f2cf0f945f01ce9