Výsledky vyhledávání - "Fiona, McPhillips"

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TTC: Trying to Conceive : The Irish Couple's Guide

Autor: Fiona McPhillips

As Ireland's baby boom reaches childbearing age, one in six couples are seeking help to have a baby, and it is estimated that this figure will rise to one in four over the next twenty years. In TTC: The Irish Couple's Guide to Trying to Conceive, Fio

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Antisense Oligonucleotide Targeting of Raf-1

Autor: Kenneth G. MacLeod, John F. Smyth, Simon P. Langdon, Fiona McPhillips, Peter Mullen, Brett P. Monia

Publikováno v: Clinical Cancer Research. 10:2100-2108

Purpose: We sought to identify determinants of growth response to the Raf-1-targeted antisense oligonucleotide (ASO; ISIS 5132) using a large panel of ovarian cancer cell lines. Experimental Design: First-(ISIS 5132) and second-generation (ISIS 13650

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c20621b56071576a1399d6ad6fed75b
https://doi.org/10.1158/1078-0432.ccr-03-0154

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Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer

Autor: A.A. Ritchie, John F. Smyth, Brett P. Monia, Peter Mullen, Simon P. Langdon, Fiona McPhillips, F A Dorr

Publikováno v: British Journal of Cancer
2001, ' Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer. ', British Journal of Cancer, vol. 85, pp. 1753-1758 . https://doi.org/10.1054/bjoc.2001.2139

c-Raf is an essential component of the extracellular related kinase (ERK) signal transduction pathway. Immunohistochemical staining indicated that c-Raf was present in 49/53 ovarian adenocarcinomas investigated and high c-Raf expression correlated si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f1d7f9459b30aecf2b379594770975
https://doi.org/10.1054/bjoc.2001.2139

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Lipoxin A4 Antagonizes the Mitogenic Effects of Leukotriene D4 in Human Renal Mesangial Cells

Autor: Blaithin A. McMahon, Catherine Godson, Aine Fanning, Fiona McPhillips, Catherine Stenson, Hugh R. Brady

Publikováno v: Journal of Biological Chemistry. 275:27566-27575

The lipoxygenase-derived eicosanoids leukotrienes and lipoxins are well defined regulators of hemeodynamics and leukocyte recruitment in inflammatory conditions. Here, we describe a novel bioaction of lipoxin A4(LXA4), namely inhibition of leukotrien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19f66210f484fd51bcf7fd5aa2d8ef30
https://doi.org/10.1074/jbc.m001015200

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Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo

Autor: Pinpin Lin, John J. Voorhees, Gary J. Fisher, Yinsheng Wan, Jiayuh Lin, Xiao Yan Li, Zeng Quan Wang, Harvinder S. Talwar, Sewon Kang, Fiona McPhillips

Publikováno v: Journal of Clinical Investigation. 101:1432-1440

Human skin is exposed daily to solar ultraviolet (UV) radiation. UV induces the matrix metalloproteinases collagenase, 92-kD gelatinase, and stromelysin, which degrade skin connective tissue and may contribute to premature skin aging (photoaging). Pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2117eaadd2e6055c9913288d4189c23a
https://doi.org/10.1172/jci2153

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Raf-1 is the predominant Raf isoform that mediates growth factor-stimulated growth in ovarian cancer cells

Autor: John F. Smyth, Kenneth G. MacLeod, Simon P. Langdon, Brett P. Monia, Jane M Sewell, David Cameron, Peter Mullen, Fiona McPhillips

Publikováno v: Carcinogenesis. 27(4)

There is currently much interest in the role of the Raf family in cancer, particularly since mutated B-Raf has been shown to be oncogenic in certain disease types. In this study we have explored the expression, signaling and function of the three kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550d24804c5aa4fccf4b082d1e35245f
https://pubmed.ncbi.nlm.nih.gov/16332724

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Comparison of strategies targeting Raf-1 mRNA in ovarian cancer

Autor: Brett P. Monia, John F. Smyth, Fiona McPhillips, Simon P. Langdon, Peter Mullen

Publikováno v: International journal of cancer. 118(6)

In this study, we characterize the uptake and specificity of a first-generation Raf-1 antisense oligonucleotide (ASO) (ISIS 5132) and compare it with a second-generation ASO (ISIS 13650) and an RNA interference approach. All three approaches resulted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94ab66ad74ace59f390616f5997681e
https://pubmed.ncbi.nlm.nih.gov/16184551

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Antisense oligonucleotide targeting of Raf-1: importance of raf-1 mRNA expression levels and raf-1-dependent signaling in determining growth response in ovarian cancer

Autor: Peter, Mullen, Fiona, McPhillips, Kenneth, MacLeod, Brett, Monia, John F, Smyth, Simon P, Langdon

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 10(6)

We sought to identify determinants of growth response to the Raf-1-targeted antisense oligonucleotide (ASO; ISIS 5132) using a large panel of ovarian cancer cell lines.First-(ISIS 5132) and second-generation (ISIS 13650) anti-Raf 1 ASOs were compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41a8e89844c44267df27756e8776ed42
https://pubmed.ncbi.nlm.nih.gov/15041731

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