Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fiona, Jeganathan"'
Autor:
Nicky Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah Woodward, Benjamin Atkinson, Elliott Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnu, Sarah Jolly, Luca Vecchia, Reinis Ruza, Svend Kjaer, Steven Howell, Ambrosius Snidjers, Magda Bictash, Patricia Salinas, Jean-Paul Vincent, Yvonne Jones, Paul Whiting, Paul Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8addc522ec8ef944de3c1786ccffb9ca
https://doi.org/10.26434/chemrxiv-2022-f05w8
https://doi.org/10.26434/chemrxiv-2022-f05w8
Autor:
Yuguang Zhao, William Mahy, Nicky J. Willis, Hannah L. Woodward, David Steadman, Elliott D. Bayle, Benjamin N. Atkinson, James Sipthorp, Luca Vecchia, Reinis R. Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C. Salinas, Paul Whiting, Jean-Paul Vincent, Paul V. Fish, E. Yvonne Jones
The Wnt signaling suppressor Notum is a promising target for osteoporosis, Alzheimer's disease, and colorectal cancers. To develop novel Notum inhibitors, we used an X-ray crystallographic fragment screen with the Diamond-SGC Poised Library (DSPL) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f547dc38fab64d9f08bf48b45b75fa9e
Autor:
Nicky J. Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L. Woodward, Benjamin N. Atkinson, Elliott D. Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R. Ruza, Svend Kjær, Steven Howell, Ambrosius P. Snijders, Magda Bictash, Patricia C. Salinas, Jean-Paul Vincent, E. Yvonne Jones, Paul Whiting, Paul V. Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human diseases such as colorectal cancer and Alzheimer's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3474b8ac04a0b606e41a67edadf62c69
Autor:
Benjamin N, Atkinson, David, Steadman, Yuguang, Zhao, James, Sipthorp, Luca, Vecchia, Reinis R, Ruza, Fiona, Jeganathan, Georgie, Lines, Sarah, Frew, Amy, Monaghan, Svend, Kjær, Magda, Bictash, E Yvonne, Jones, Paul V, Fish
Publikováno v:
MedChemComm
Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.
NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resul
NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbb625a59f2dade8bff75e1d10556061
https://pubmed.ncbi.nlm.nih.gov/31534655
https://pubmed.ncbi.nlm.nih.gov/31534655
Autor:
Emiliano Tamanini, Joseph E. Coyle, Agnes C. L. Martin, Adam Hold, Elisabetta Chiarparin, Sharna J. Rich, Ludovic Drouin, Puja Pathuri, Rob L. M. van Montfort, Tom D. Heightman, Marcello Tortorici, Finn P. Holding, Jeff Yon, Amy Wood, Rosemary Burke, Fiona Jeganathan, Yvette Newbatt, Nader Amin, Jenny E. Harmer, Maura Westlake, Paul Acklam, Swen Hoelder, Valerio Berdini, Dominic Tisi
Publikováno v:
ACS Chemical Biology. 11:3093-3105
The members of the NSD subfamily of lysine methyl transferases are compelling oncology targets due to the recent characterization of gain-of-function mutations and translocations in several hematological cancers. To date, these proteins have proven i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b87831640666c49d5bf755877b17f0
https://doi.org/10.1021/acschembio.6b00308
https://doi.org/10.1021/acschembio.6b00308
Autor:
Isaac M. Westwood, Matthew D. Cheeseman, Ian Collins, James Osborne, Rob L. M. van Montfort, Fiona Jeganathan, Martin G. Rowlands, Nadia Kadi, Keith Jones, Manjuan Liu, Norhakim Yahya, Craig McAndrew, Thomas P. Matthews, Paul Workman, Meirion Richards, Alan M. Jones, Diane Frances Lee, S.E. Dobson, Rosemary Burke
Publikováno v:
'Scientific Reports ', vol: 6, pages: 34701-1-34701-13 (2016)
Scientific Reports
Scientific Reports
The heat shock protein 70s (HSP70s) are molecular chaperones implicated in many cancers and of significant interest as targets for novel cancer therapies. Several HSP70 inhibitors have been reported, but because the majority have poor physicochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab9df848e6b209d423994a3e33e978a
https://doi.org/10.1038/srep34701
https://doi.org/10.1038/srep34701
Autor:
Matthew D, Cheeseman, Isaac M, Westwood, Olivier, Barbeau, Martin, Rowlands, Sarah, Dobson, Alan M, Jones, Fiona, Jeganathan, Rosemary, Burke, Nadia, Kadi, Paul, Workman, Ian, Collins, Rob L M, van Montfort, Keith, Jones
Publikováno v:
Journal of Medicinal Chemistry
HSP70 is a molecular chaperone and a key component of the heat-shock response. Because of its proposed importance in oncology, this protein has become a popular target for drug discovery, efforts which have as yet brought little success. This study d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cecd3779206534708e239781bc59d4b6
https://pubmed.ncbi.nlm.nih.gov/27119979
https://pubmed.ncbi.nlm.nih.gov/27119979
Autor:
Philip Stephens, Katja E. Hill, Robert G. Price, David Wynne Williams, Dirk Wildeboer, Andrew David Riddell, Fiona Jeganathan, Ramadan A. Abuknesha, David Thomas, Patricia Elaine Price
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases. 31:2183-2189
Chronic non-healing wounds are a major health problem with resident bacteria strongly implicated in their impaired healing. A rapid-screen to provide detailed knowledge of wound bacterial populations would therefore be of value and help prevent unnec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b1cd11909aba43a21921b8c7c7ad67
https://doi.org/10.1007/s10096-012-1553-6
https://doi.org/10.1007/s10096-012-1553-6
Publikováno v:
Analytical and Bioanalytical Chemistry. 401:2195-2204
Acetaminophen antibodies were purified using affinity chromatography and labelled with horseradish peroxidase (HRP). The antibody-HRP conjugate and a new acetaminophen derivative were used in the construction of two immunoassay methods facilitating t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f420eb339d41a6df43d2eb6b53b908
https://doi.org/10.1007/s00216-011-5272-0
https://doi.org/10.1007/s00216-011-5272-0
Publikováno v:
Talanta. 81:1237-1244
Bacterial proteases, Type XXIV from Bacillus licheniformens and Type XIV from Streptomyces griseus, were used to investigate the utility and optimisation of a solid phase assay for proteases, using immunoglobulin proteins as substrates. Immunoglobuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec793fcd76d0fafeeb6acb6acdc13004
https://doi.org/10.1016/j.talanta.2010.02.015
https://doi.org/10.1016/j.talanta.2010.02.015