Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Finn, Drabløs"'
Autor:
Ashish Kumar Singh, Bente Talseth-Palmer, Alexandre Xavier, Rodney J. Scott, Finn Drabløs, Wenche Sjursen
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background Hereditary genetic mutations causing predisposition to colorectal cancer are accountable for approximately 30% of all colorectal cancer cases. However, only a small fraction of these are high penetrant mutations occurring in DNA m
Externí odkaz:
https://doaj.org/article/df653a93103441799041e9df5550660a
Autor:
Ashish Kumar Singh, Maren Fridtjofsen Olsen, Liss Anne Solberg Lavik, Trine Vold, Finn Drabløs, Wenche Sjursen
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Background Detection of copy number variation (CNV) in genes associated with disease is important in genetic diagnostics, and next generation sequencing (NGS) technology provides data that can be used for CNV detection. However, CNV detectio
Externí odkaz:
https://doaj.org/article/84d201fa49674f48a6b546f71115b19b
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Objective Properties of gene products can be described or annotated with Gene Ontology (GO) terms. But for many genes we have limited information about their products, for example with respect to function. This is particularly true for long
Externí odkaz:
https://doaj.org/article/d86c61f24efe431cbcab6460dd52ce93
Autor:
Morten Beck Rye, Sebastian Krossa, Martina Hall, Casper van Mourik, Tone F. Bathen, Finn Drabløs, May-Britt Tessem, Helena Bertilsson
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104451- (2022)
Summary: High secretion of the metabolites citrate and spermine is a unique hallmark for normal prostate epithelial cells, and is reduced in aggressive prostate cancer. However, the identity of the genes controlling this biological process is mostly
Externí odkaz:
https://doaj.org/article/c1978d3a0f9542138e117ae053f48e81
Autor:
Rezvan Ehsani, Finn Drabløs
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Diseases like cancer will lead to changes in gene expression, and it is relevant to identify key regulatory genes that can be linked directly to these changes. This can be done by computing a Regulatory Impact Factor (RIF) score f
Externí odkaz:
https://doaj.org/article/b2d6720fef134a3d92863c939a73e607
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Mitochondrial activity in cancer cells has been central to cancer research since Otto Warburg first published his thesis on the topic in 1956. Although Warburg proposed that oxidative phosphorylation in the tricarboxylic acid (TCA) cycle was perturbe
Externí odkaz:
https://doaj.org/article/1296c89fe0294f278975c39d75dc6c16
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countries. Unlike several other types of cancer, PCa has few genetic drivers, which has led researchers to look for additional epigenetic and trans
Externí odkaz:
https://doaj.org/article/e1d0911838fc46fe938c5754adcd265e
Recommendations for the FAIRification of genomic track metadata [version 1; peer review: 2 approved]
Autor:
Sveinung Gundersen, Sanjay Boddu, Salvador Capella-Gutierrez, Finn Drabløs, José M. Fernández, Radmila Kompova, Kieron Taylor, Dmytro Titov, Daniel Zerbino, Eivind Hovig
Publikováno v:
F1000Research, Vol 10 (2021)
Background: Many types of data from genomic analyses can be represented as genomic tracks, i.e. features linked to the genomic coordinates of a reference genome. Examples of such data are epigenetic DNA methylation data, ChIP-seq peaks, germline or s
Externí odkaz:
https://doaj.org/article/776b1772122046bbb4915a62dc7b0e16
Autor:
Mariève J. Rocque, Vilde Leipart, Ashish Kumar Singh, Pilar Mur, Maren F. Olsen, Lars F. Engebretsen, Edgar Martin-Ramos, Rosa Aligué, Pål Sætrom, Laura Valle, Finn Drabløs, Marit Otterlei, Wenche Sjursen
Publikováno v:
Molecular Genetics and Genomics. 298:555-566
The cancer syndrome polymerase proofreading-associated polyposis results from germline mutations in the POLE and POLD1 genes. Mutations in the exonuclease domain of these genes are associated with hyper- and ultra-mutated tumors with a predominance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45ecbf01727d42413c12d729d931ffe5
https://doi.org/10.1007/s00438-023-02000-w
https://doi.org/10.1007/s00438-023-02000-w
Autor:
Rezvan Ehsani, Finn Drabløs
Publikováno v:
Cancer Informatics, Vol 19 (2020)
The k -Nearest Neighbor ( k NN) classifier represents a simple and very general approach to classification. Still, the performance of k NN classifiers can often compete with more complex machine-learning algorithms. The core of k NN depends on a “g
Externí odkaz:
https://doaj.org/article/6ded556875cc4c4d96e7dc788160d233