Výsledky vyhledávání - "Finly Philip"

Regulation of the activity of the promoter of RNA-induced silencing, C3PO

Autor: Shriya Sahu, Giuseppe Caso, Walter Zurawsky, Alberto Perez, Leo Williams, Finly Philip, Suzanne Scarlata

Publikováno v: Protein Science. 26:1807-1818

RNA-induced silencing is a process which allows cells to regulate the synthesis of specific proteins. RNA silencing is promoted by the protein C3PO (component 3 of RISC). We have previously found that phospholipase Cβ, which increases intracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58a18c4e9dc75609fb58007bd49ac44d
https://doi.org/10.1002/pro.3219

Zobrazit plný text záznamu

Phospholipase Cβ connects G protein signaling with RNA interference

Autor: Suzanne Scarlata, Urszula Golebiewska, Osama Garwain, Finly Philip, Shriya Sahu, Imanol Gonzalez Burguera, Leo Williams, Yuanjian Guo, Barbara Rosati

Publikováno v: Advances in Biological Regulation. 61:51-57

Phosphoinositide-specific-phospholipase Cβ (PLCβ) is the main effector of Gαq stimulation which is coupled to receptors that bind acetylcholine, bradykinin, dopamine, angiotensin II as well as other hormones and neurotransmitters. Using a yeast tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2f96412c6bcf3f367dee45bcdd62f4
https://doi.org/10.1016/j.jbior.2015.11.006

Zobrazit plný text záznamu

Hydrolysis Rates of Different Small Interfering RNAs (siRNAs) by the RNA Silencing Promoter Complex, C3PO, Determines Their Regulation by Phospholipase Cβ

Autor: Suzanne Scarlata, Finly Philip, Shriya Sahu

Publikováno v: Journal of Biological Chemistry. 289:5134-5144

C3PO plays a key role in promoting RNA-induced gene silencing. C3PO consists of two subunits of the endonuclease translin-associated factor X (TRAX) and six subunits of the nucleotide-binding protein translin. We have found that TRAX binds strongly t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c04edb433ab8d13edcfce4d7440319d
https://doi.org/10.1074/jbc.m113.531467

Zobrazit plný text záznamu

Role of phospholipase C-β in RNA interference

Autor: Giuseppe Caso, Finly Philip, Shriya Sahu, Suzanne Scarlata

Publikováno v: Advances in Biological Regulation. 53:319-330

Phospholipase C-β (PLC β) enzymes are activated by G proteins in response to agents such as hormones and neurotransmitters, and have been implicated in leukemias and neurological disorders. PLCβ activity causes an increase in intracellular calcium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb67c1e00b012336ca097c2d867dbfc
https://doi.org/10.1016/j.jbior.2013.07.002

Zobrazit plný text záznamu

Synergistic Ca2+ Responses by Gαi- and Gαq-coupled G-protein-coupled Receptors Require a Single PLCβ Isoform That Is Sensitive to Both Gβγ and Gαq

Autor: Robert A. Rebres, Melvin I. Simon, Leah A. Santat, William E. Seaman, Elliott M. Ross, Finly Philip, Tamara I. A. Roach, Iain D. C. Fraser, Keng Mean Lin, Lucas Cheadle, Christina Moon, Jamie Liu

Publikováno v: Journal of Biological Chemistry. 286:942-951

Cross-talk between Gα(i)- and Gα(q)-linked G-protein-coupled receptors yields synergistic Ca(2+) responses in a variety of cell types. Prior studies have shown that synergistic Ca(2+) responses from macrophage G-protein-coupled receptors are primar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37626920e0d641e4c24a91127824d39
https://doi.org/10.1074/jbc.m110.198200

Zobrazit plný text záznamu

Synergistic Activation of Phospholipase C-β3 by Gαq and Gβγ Describes a Simple Two-State Coincidence Detector

Autor: Jimmy Woodson, Ganesh Kadamur, Rosa Gonzalez Silos, Finly Philip, Elliott M. Ross

Publikováno v: Current Biology. 20:1327-1335

Summary Background Receptors that couple to G i and G q often interact synergistically in cells to elicit cytosolic Ca 2+ transients that are several-fold higher than the sum of those driven by each receptor alone. Such synergism is commonly assumed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5846f91817dbec539cda6e45f534b07
https://doi.org/10.1016/j.cub.2010.06.013

Zobrazit plný text záznamu

Regulation of the Promoter of RNA Silencing

Autor: Shriya Sahu, Giuseppe Caso, Walter Zurawsky, Alberto Perez, Finly Philip, Leo Williams, Suzanne Scarlata

Publikováno v: Biophysical Journal. 114:67a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4951fd57dc2ddeabb74e6efb6a95fc28
https://doi.org/10.1016/j.bpj.2017.11.413

Zobrazit plný text záznamu

Caveolin-1 alters Ca2+ signal duration through specific interaction with the Gαq family of G proteins

Autor: Parijat Sengupta, Finly Philip, Suzanne Scarlata

Publikováno v: Journal of Cell Science. 121:1363-1372

Caveolae are membrane domains having caveolin-1 (Cav1) as their main structural component. Here, we determined whether Cav1 affects Ca(2+) signaling through the Galpha(q)-phospholipase-Cbeta (PLCbeta) pathway using Fischer rat thyroid cells that lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a138557f20555ddf0cff65da0d058a91
https://doi.org/10.1242/jcs.020081

Zobrazit plný text záznamu

Signaling through a G Protein-coupled Receptor and Its Corresponding G Protein Follows a Stoichiometrically Limited Model

Autor: Parijat Sengupta, Finly Philip, Suzanne Scarlata

Publikováno v: Journal of Biological Chemistry. 282:19203-19216

The bradykinin receptor is a G protein-coupled receptor (GPCR) that is coupled to the Galpha(q) family of heterotrimeric G proteins. In general, a GPCR can exert intracellular signals either by transiently associating with multiple diffusing G protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6565e6eef1b3d75538fc19d90de2eea
https://doi.org/10.1074/jbc.m701558200

Zobrazit plný text záznamu

RNA-induced silencing attenuates G protein-mediated calcium signals

Autor: Finly Philip, Urszula Golebiewska, Suzanne Scarlata, Shriya Sahu

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(5)

Phospholipase Cβ (PLCβ) is activated by G protein subunits in response to environmental stimuli to increase intracellular calcium. In cells, a significant portion of PLCβ is cytosolic, where it binds a protein complex required for efficient RNA-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f9a86470bb573fe7c20a23d098efea
https://pubmed.ncbi.nlm.nih.gov/26862135

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání