Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Fink, David M."'
Autor:
Harris, J. Irene, Strom, Thad Q., Jain, Shaili, Doble, Timothy, Raisl, Holly, Hundt, Natalie, Polusny, Melissa, Fink, David M., Erbes, Christopher
Publikováno v:
In Cognitive and Behavioral Practice May 2020 27(2):113-125
Autor:
Fernando Camacho, Fink David M, Olsen Gordon Edward, Lawrence L. Martin, Wayne W. Petko, Richard C. Effland, Hugo M. Vargas, Craig P. Smith, David E. Selk, Douglas K. Rush, Klein Joseph Thomas, Peter Allen Nemoto, Larry Davis, Gina M. Bores, James T. Winslow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:157-162
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. Compound 5a (P10358, 1-[3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a6f4a2e14f8942baf3115f4bd52456a
https://doi.org/10.1016/s0960-894x(96)00592-6
https://doi.org/10.1016/s0960-894x(96)00592-6
Autor:
Kurys Barbara E, Michael C. Merriman, Olsen Gordon Edward, Fink David M, Mark G. Palermo, Francis P. Huger, Gina M. Bores, Wayne W. Petko, Gerard J. O'Malley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:625-630
A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::028dcf8fee9ea564376729116d03aa6f
https://doi.org/10.1016/0960-894x(96)00072-8
https://doi.org/10.1016/0960-894x(96)00072-8
Autor:
Richard C. Effland, Fink David M
Publikováno v:
Synthetic Communications. 24:2793-2796
A series of 5-(1-aminocyclohexyl)-2(1H)-pyridinones was prepared in 16-32% yield. The key step is a Ritter reaction of the analogous alcohols. The results reported demonstrate the difference in reactivity between the closely related 2-alkoxy-pyridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dec39797722520f8a84d896381732ae
https://doi.org/10.1080/00397919408010597
https://doi.org/10.1080/00397919408010597
Autor:
Fink David M, Richard C. Effland
Publikováno v:
ChemInform. 26
A series of 5-(1-aminocyclohexyl)-2(1H)-pyridinones was prepared in 16-32% yield. The key step is a Ritter reaction of the analogous alcohols. The results reported demonstrate the difference in reactivity between the closely related 2-alkoxy-pyridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d09d2003a2204d7633192b0fecdd75
https://doi.org/10.1002/chin.199513177
https://doi.org/10.1002/chin.199513177
Autor:
Richard C. Effland, Kurys Barbara E, Fink David M, Francis P. Huger, Douglas K. Rush, Gina M. Bores, David E. Selk
Publikováno v:
ChemInform. 26
A series of 5-amino-5,6,7,8-tetrahydroquinolinones was designed and synthesized as acetylcholinesterase inhibitors. The compounds are related to hyperzine A, a naturally occurring cholinesterase inhibitor. They inhibit acetylcholinesterase in vitro,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3d08385cb69344524b489df43813432
https://doi.org/10.1002/chin.199552146
https://doi.org/10.1002/chin.199552146
Autor:
Klein Joseph Thomas, Craig P. Smith, Fink David M, Wayne W. Petko, Richard C. Effland, Douglas K. Rush, Peter Allen Nemoto, Fernando Camacho, Olsen Gordon Edward, Larry Davis, Gina M. Bores, James T. Winslow, David E. Selk, Hugo M. Vargas, Lawrence L. Martin
Publikováno v:
ChemInform. 28
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. Compound 5a (P10358, 1-[3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41000ba1c31656f9c84fb42e02ee999a
https://doi.org/10.1002/chin.199720130
https://doi.org/10.1002/chin.199720130
Autor:
Erich F. Paulus, Fink David M, Kurys Barbara E, Brian S. Freed, Gregory H. Merriman, Jennifer Varriano, Shelly Pavlek
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647b5231d26336fdbf09555dd1f88c90
https://doi.org/10.1002/chin.200017141
https://doi.org/10.1002/chin.200017141
Autor:
Jennifer Varriano, Brian S. Freed, Kurys Barbara E, Shelly Pavlek, Erich F. Paulus, Gregory H. Merriman, Fink David M
Publikováno v:
Synlett. 2000:137-139
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abf231f6758c7691c6b1457bf98bdcc8
https://doi.org/10.1055/s-2000-6462
https://doi.org/10.1055/s-2000-6462
Autor:
Claude Oberlander, Fink David M, D. Cunningham, David E. Selk, Gina M. Bores, Eva Marie DiLeo, Karen M. Brooks, Anne Dekeyne, Hugo M. Vargas, James T. Winslow, Fernando Camacho, Larry Davis, Andrew Giovanni, Craig P. Smith, Lily Zhou, Mary Li, Douglas J. Turk, Douglas K. Rush
Publikováno v:
Alzheimer Disease ISBN: 9781461286608
Alzheimer’s disease (AD) is a complex and multifaceted neurodegenerative disease characterized by cognitive and behavioral abnormalities. The primary cognitive deficit has been correlated with extensive cholinergic dysfunction and the efficacy of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78da4f39c0cda4f567db083accd61316
https://doi.org/10.1007/978-1-4612-4116-4_37
https://doi.org/10.1007/978-1-4612-4116-4_37
