Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Finith E. Jernigan"'
Autor:
Alykhan M. Premji, Swati S. Bhasin, Revanth Kosaraju, Roberto C. De La Rosa, Jae Eun Cheong, Steffi K. Koerner, Yiqiang Wang, Eden Park, Jiaxuan Chen, Diane D. Park, Beena E Thomas, Julian Kwan, Finith E. Jernigan, Andrew Emili, Alan C. Moss, Elliot L. Chaikof, Manoj Bhasin, Daniel J. Wong, Liying Liu, Carolyn A. Haller, Lijun Sun
Publikováno v:
Science Advances
Heterocyclic aryl hydrocarbon receptor agonists modulate lymphocyte-mediated tissue repair in a murine model of colitis.
Aryl hydrocarbon receptor (AHR) is an essential regulator of gut immunity and a promising therapeutic target for inflammator
Aryl hydrocarbon receptor (AHR) is an essential regulator of gut immunity and a promising therapeutic target for inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c11a87f609c742804bf463e4a97169
https://doi.org/10.1126/sciadv.aay8230
https://doi.org/10.1126/sciadv.aay8230
Autor:
Andreas Hedblom, Finith E. Jernigan, Barbara Wegiel, Yiqiang Wang, Mailin Li, Lijun Sun, Steffi K. Koerner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5703-5706
A series of novel chalcones were synthesized by the Claisen-Schmidt condensation reaction of tetralones and 5-/6-indolecarboxaldehydes. Treatment of human lung cancer cell line harboring Kras mutation (A549) with the chalcones induced dose-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203044963c216b5df2111e1bc4a22ea4
https://doi.org/10.1016/j.bmcl.2016.10.063
https://doi.org/10.1016/j.bmcl.2016.10.063
Autor:
Ivy Chung, Michela Zaffagni, Jae Eun Cheong, Yiqiang Wang, Finith E. Jernigan, Bruce R. Zetter, Lijun Sun, Yingjie Xu
Publikováno v:
European journal of medicinal chemistry. 144
Metastases account for more than 90% of all cancer deaths and respond poorly to most therapies. There remains an urgent need for new therapeutic modalities for the treatment of advanced metastatic cancers. The benzimidazole methylcarbamate drugs, com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479c4bb6712555d146195ab1bd786090
https://pubmed.ncbi.nlm.nih.gov/29288939
https://pubmed.ncbi.nlm.nih.gov/29288939
Autor:
Melanie A. Priestman, Finith E. Jernigan, Qunzhao Wang, Marion Schmidt, David S. Lawrence, Ruma Chowdhury
Publikováno v:
ACS Chemical Biology
The proteasome, a validated anticancer target, participates in an array of biochemical activities, which range from the proteolysis of defective proteins to antigen presentation. We report the preparation of biochemically and photophysically distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127d50c8dec5a984fa451041b20a9945
http://europepmc.org/articles/PMC4340355
http://europepmc.org/articles/PMC4340355
Publikováno v:
Angewandte Chemie International Edition. 53:3975-3978
In vivo optical imaging must contend with the limitations imposed by the optical window of tissue (600–1000 nm). Although a wide array of fluorophores are available that are visualized in the red and near-IR region of the spectrum, with the excepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd6417fd4d2f6271e52d405a6d68a88
https://doi.org/10.1002/anie.201309691
https://doi.org/10.1002/anie.201309691
Autor:
Miwa Oki, Sha Bai, Vikas P. Sukhatme, Finith E. Jernigan, Steffi K. Koerner, Lijun Sun, Jun-ichi Hanai, Chieko Komaba, Emi Shuto
Publikováno v:
European journal of medicinal chemistry. 126
Aberrant cellular metabolism drives cancer proliferation and metastasis. ATP citrate lyase (ACL) plays a critical role in generating cytosolic acetyl CoA, a key building block for de novo fatty acid and cholesterol biosynthesis. ACL is overexpressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5deb98affffe8abfcfa08fb4804b928
https://pubmed.ncbi.nlm.nih.gov/27997879
https://pubmed.ncbi.nlm.nih.gov/27997879
Publikováno v:
Cell cycle (Georgetown, Tex.). 15(9)
Efficacy of current therapies for advanced and metastatic cancers remains a challenge in clinical practice. We investigated the anti-cancer potency of three novel indoly-chalcones (CITs). Our results indicated the lead molecule CIT-026 (Formula = C20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f0bb391253f988639b0cb56625ec9f
https://pubmed.ncbi.nlm.nih.gov/26986925
https://pubmed.ncbi.nlm.nih.gov/26986925
Autor:
Hanna S. Radomska, Finith E. Jernigan, Sohei Nakayama, Susan E. Jorge, Daniel G. Tenen, Susumu Kobayashi, Lijun Sun
Publikováno v:
Journal of biomolecular screening. 20(9)
Recent progress of genetic studies has dramatically unveiled pathogenesis of acute myeloid leukemia (AML). However, overall survival of AML still remains unsatisfactory, and development of novel therapeutics is required. CCAAT/enhancer binding protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bf24dbdf2a9ad6a7807dd49796c51f
https://pubmed.ncbi.nlm.nih.gov/26109609
https://pubmed.ncbi.nlm.nih.gov/26109609
Autor:
David S. Lawrence, Finith E. Jernigan
An anthraquinone-based fluorescent quencher is described that is applicable to fluorophores throughout the visible spectrum and into the near IR. This species has been used to construct a palate of multicolour sensors of proteolysis and photolysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850cdab09ac04d113314aab772b2f396
A fluorescent sensor of protein kinase activity has been developed and used to characterize the compartmentalized location of cAMP-dependent protein kinase activity in mitochondria. The sensor functions via a phosphorylation-induced release of a quen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cedbf6e639f3e2ec4691b013de73b0