Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Finian Leeper"'
Autor:
Miguel A. Matilla, Rita E. Monson, Annabel Murphy, Muriel Schicketanz, Alison Rawlinson, Caia Duncan, Juan Mata, Finian Leeper, George P. C. Salmond
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT The increasing emergence of drug-resistant fungal infections has necessitated a search for new compounds capable of combating fungal pathogens of plants, animals, and humans. Microorganisms represent the main source of antibiotics with appli
Externí odkaz:
https://doaj.org/article/f5201aa4ea86443b80a01ed81f16d1ea
A key step in the biosynthesis of numerous polyketides is the stereospecific formation of a spiroacetal (spiroketal). We report here that spiroacetal formation in the biosynthesis of the macrocyclic polyketides ossamycin and oligomycin involves catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::406dbc095e9ff8c5becfb8cd9c960bcd
https://doi.org/10.26434/chemrxiv-2022-h4v7z
https://doi.org/10.26434/chemrxiv-2022-h4v7z
Autor:
Junhong, Guo, Fanglu, Huang, Chuan, Huang, Xiaobo, Duan, Xinyun, Jian, Finian, Leeper, Zixin, Deng, Peter F, Leadlay, Yuhui, Sun
Publikováno v:
Chemistry & Biology
Summary Gentamicin C complex is a mixture of aminoglycoside antibiotics used to treat severe Gram-negative bacterial infections. We report here key features of the late-stage biosynthesis of gentamicins. We show that the intermediate gentamicin X2, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::442c351678b67584b241b8c68a439d43
https://pubmed.ncbi.nlm.nih.gov/24746560
https://pubmed.ncbi.nlm.nih.gov/24746560