Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Finian James Leeper"'
Autor:
Alex H. Y. Chan, Terence C. S. Ho, Rimsha Irfan, Rawia A. A. Hamid, Emma S. Rudge, Amjid Iqbal, Alex Turner, Anna K. H. Hirsch, Finian James Leeper
Thiamine diphosphate (ThDP), the bioactive form of vitamin B1, is an essential coenzyme needed for processes of cellular metabolism in all organisms. ThDP-dependent enzymes all require ThDP as a coenzyme for catalytic activity, although individual en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f82fb0a41380db0211b18f48e05890e
https://doi.org/10.26434/chemrxiv-2023-fmf8r-v2
https://doi.org/10.26434/chemrxiv-2023-fmf8r-v2
Autor:
Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rebecca Pope, Kevin J. Saliba, Finian James Leeper
Thiamine (vitamin B1) is metabolised into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine-utilisation leads to disease states and thiamine/ThDP analogues are commonly used as antagonists of thiamine-utilisation pathways to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71f396327cacf38d0376bf285621c26
https://doi.org/10.26434/chemrxiv-2023-5qgth
https://doi.org/10.26434/chemrxiv-2023-5qgth
Pyruvate dehydrogenase complex (PDHc) suppression has long been regarded as a mechanism for cancer cells to manifest the well-known Warburg effect. However, in recent years, it has been proposed that whether PDHc is suppressed or activated in cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892deeb1c2c24a6f7de8999267066853
https://doi.org/10.26434/chemrxiv-2022-scv2t
https://doi.org/10.26434/chemrxiv-2022-scv2t
Autor:
Finian James Leeper
Publikováno v:
Topics in Current Chemistry ISBN: 9783540665731
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab5e345109906ccefbfd77aab4655d99
https://doi.org/10.1007/3-540-48146-x
https://doi.org/10.1007/3-540-48146-x
Autor:
Finian James Leeper
Publikováno v:
Topics in Current Chemistry ISBN: 9783540634188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::783792c0e2893c9a0ac99a46fb9cf3ae
https://doi.org/10.1007/3-540-69542-7
https://doi.org/10.1007/3-540-69542-7
Publikováno v:
Europe PubMed Central
As a result of speculation that many enzymes control polyketone cyclization in vivo by converting a key carbonyl group to a cis-enol ether derivative, we describe two novel biomimetic cyclizations. The first involves condensation of two C6 units deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::511fbe589820f66c7e1f7dca239dd785
http://europepmc.org/abstract/med/246777
http://europepmc.org/abstract/med/246777