Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Finian J, Leeper"'
Publikováno v:
ACS Omega, Vol 9, Iss 41, Pp 42245-42252 (2024)
Externí odkaz:
https://doaj.org/article/614b5dd2a0a2435181a44d95c8804f1e
Autor:
Flaviu Bulat, Friederike Hesse, De-En Hu, Susana Ros, Connor Willminton-Holmes, Bangwen Xie, Bala Attili, Dmitry Soloviev, Franklin Aigbirhio, Finian. J. Leeper, Kevin M. Brindle, André A. Neves
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Introduction Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treatment can give an in
Externí odkaz:
https://doaj.org/article/e21d4f55168b4903adafd4356cd7f69c
Autor:
Annabel C. Murphy, Matthew Corney, Rita E. Monson, Miguel A. Matilla, George P. C. Salmond, Finian J. Leeper
Publikováno v:
ACS Chemical Biology. 18:1148-1157
Dickeya solani, a plant-pathogenic bacterium, produces solanimycin, a potent hybrid polyketide/nonribosomal peptide (PKS/NRPS) anti-fungal compound. The biosynthetic gene cluster responsible for synthesis of this compound has been identified. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fd766d2968a5be47ff426d36d8fdae
https://doi.org/10.1021/acschembio.2c00947
https://doi.org/10.1021/acschembio.2c00947
Publikováno v:
Organic & Biomolecular Chemistry. 21:1755-1763
Acknowledgements: AHYC and TCSH were funded by K. M. Medhealth and DRP by an EPSRC studentship.
Suppression of pyruvate dehydrogenase complex (PDHc) is a mechanism for cancer cells to manifest the Warburg effect. However, recent evidence suggest
Suppression of pyruvate dehydrogenase complex (PDHc) is a mechanism for cancer cells to manifest the Warburg effect. However, recent evidence suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e138ad50e28166510876321a3c53a5cb
https://doi.org/10.1039/d2ob02272a
https://doi.org/10.1039/d2ob02272a
Autor:
Oksana Bilyk, Gabriel S. Oliveira, Rafaela M. de Angelo, Michell O. Almeida, Kathia Maria Honório, Finian J. Leeper, Marcio V. B. Dias, Peter F. Leadlay
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
A key step in the biosynthesis of numerous polyketides is the stereospecific formation of a spiroacetal (spiroketal). We report here that spiroacetal formation in the biosynthesis of the macrocyclic polyketides ossamycin and oligomycin involves catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13863750d42f4599cb4b00d6cf31915
https://doi.org/10.1021/jacs.2c03313
https://doi.org/10.1021/jacs.2c03313
Autor:
Alex H. Y. Chan, Terence C. S. Ho, Imam Fathoni, Rebecca Pope, Kevin J. Saliba, Finian J. Leeper
Thiamine is metabolized into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine utilization leads to disease states. Oxythiamine, a thiamine analogue, is metabolized into oxythiamine diphosphate (OxThDP), which inhibits ThDP-dependent en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60186541de4b0b017c0b610042a5eb01
https://www.repository.cam.ac.uk/handle/1810/350318
https://www.repository.cam.ac.uk/handle/1810/350318
Autor:
Alex H.Y. Chan, Terence C.S. Ho, Rimsha Irfan, Rawia A.A. Hamid, Emma S. Rudge, Amjid Iqbal, Alex Turner, Anna K.H. Hirsch, Finian J. Leeper
Publikováno v:
Bioorganic Chemistry. 138:106602
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d0c67bf09dbd75ed5502272d4909bc0
https://doi.org/10.1016/j.bioorg.2023.106602
https://doi.org/10.1016/j.bioorg.2023.106602
Publikováno v:
Organicbiomolecular chemistry. 20(45)
Inhibition of thiamine pyrophosphate (TPP)-dependent enzymes with thiamine/TPP analogues that have the central thiazolium ring replaced with other rings is well established, but a limited number of central rings have been reported. We report a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c6a852f83d46c63cb990c93c793e5a
https://pubmed.ncbi.nlm.nih.gov/36326656
https://pubmed.ncbi.nlm.nih.gov/36326656
Autor:
Daniel R. Parle, Flaviu Bulat, Shahd Fouad, Heather Zecchini, Kevin M. Brindle, André A. Neves, Finian J. Leeper
Publikováno v:
Bioconjugate chemistry. 33(8)
Funder: Engineering and Physical Sciences Research Council
Methylcyclopropene (Cyoc)-tagged tetra-acetylated monosaccharides, and in particular mannosamine derivatives, are promising tools for medical imaging of cancer using metabolic oligosacch
Methylcyclopropene (Cyoc)-tagged tetra-acetylated monosaccharides, and in particular mannosamine derivatives, are promising tools for medical imaging of cancer using metabolic oligosacch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c571e91ecc8dee8539d34a319a2c32a3
https://pubmed.ncbi.nlm.nih.gov/35876696
https://pubmed.ncbi.nlm.nih.gov/35876696
A series of derivatives of a triazole analogue of thiamine has been synthesised. When tested as inhibitors of porcine pyruvate dehydrogenase, the benzoyl ester derivatives proved to be potent thiamine pyrophosphate (TPP) competitive inhibitors, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e0299bdf48605edea5f024541480c2
https://www.repository.cam.ac.uk/handle/1810/340736
https://www.repository.cam.ac.uk/handle/1810/340736