Výsledky vyhledávání - "Finger, L.D."

Flap endonuclease 1 mutations A159V and E160D cause genomic instability by slowing reaction on double-flap substrates

Autor: Algasaier, S.I., Finger, L.D., Bennet, I.A., Grasby, J.A.

Flap endonuclease 1 (FEN1) is a structure-selective nuclease best known for its roles in the penultimate steps of Okazaki fragment maturation, long-patch base excision repair and ribonucleotide excision repair. To better understand the role of FEN1 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b2b98e0c1ccb41615b7b3da751d31eb0
https://eprints.whiterose.ac.uk/140940/1/mFEN1paper+supplemental.pdf

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Regional Conformational Flexibility Couples Substrate Specificity and Scissile Phosphate Diester Selectivity in Human Flap Endonuclease 1

Autor: Bennet, I., Finger, L.D., Baxter, N.J., Ambrose, B., Hounslow, A., Thompson, M.J., Exell, J.C., Shahari, N.N.B.M., Craggs, T.D., Waltho, J.P., Grasby, J.A.

Human flap endonuclease-1 (hFEN1) catalyzes the divalent metal ion-dependent removal of single-stranded DNA protrusions known as flaps during DNA replication and repair. Substrate selectivity involves passage of the 5′-terminus/flap through the arc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ec910a123d3df33ba1b0f6f6e5c33d88
https://eprints.whiterose.ac.uk/130528/1/gky293_complete.pdf

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Human Exonuclease 1 Threads 5'-Flap Substrates Through its Helical Arch

Autor: Shaw, S.J., Finger, L.D., Grasby, J.A.

Human exonuclease 1 (hEXO1) is a member of the 5'-nuclease superfamily and plays important roles in DNA repair. Alongside acting as a 5'-exonuclease on blunt, gapped, nicked and 3'-overhang DNAs, hEXO1 can also act as an endonuclease removing protrud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e57ad80667bfc6257c3bef748523bc6a
https://eprints.whiterose.ac.uk/118992/1/Shaw_et_al_Revised.pdf

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DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1 Catalyzed Reaction

Autor: Algasaier, S.I., Exell, J.C., Bennet, I.A., Thompson, M.J., Gotham, V.J., Shaw, S.J., Craggs, T.D., Finger, L.D., Grasby, J.A.

Human flap endonuclease-1 (hFEN1) catalyzes the essential removal of single-stranded flaps arising at DNA junctions during replication and repair processes. hFEN1 biological function must be precisely controlled, and consequently, the protein relies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a608850369fe4fe1be58c2f35e5ff274
https://eprints.whiterose.ac.uk/95999/1/Algasaier_et_al_revised_3Feb.pdf

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Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site

Autor: Exell , J.C., Thompson , M.J., Finger, L.D., Shaw , S.J., Debreczeni , J., Ward, T.A., McWhirter , C., Siöberg , C.L.B., Molina , D.M., Abbott , W.M., Jones, C.D., Nissink, J.W.M., Durant , S.T., Grasby, J.A.

The structure-specific nuclease human flap endonuclease-1 (hFEN1) plays a key role in DNA replication and repair and may be of interest as an oncology target. We present the first crystal structure of inhibitor-bound hFEN1 and show a cyclic N-hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0936637813c80a440071c408eb3b389b
https://eprints.whiterose.ac.uk/100047/1/16050_2_merged_1462449301.pdf

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Flap endonucleases pass 5 '-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5 '-ends

Autor: Patel, N., Atack, J.M., Finger, L.D., Exell, J.C., Thompson, P., Tsutakawa, S., Tainer, J.A., Williams, D.M., Grasby, J.A.

Flap endonucleases (FENs), essential for DNA replication and repair, recognize and remove RNA or DNA 5′-flaps. Related to FEN specificity for substrates with free 5′-ends, but controversial, is the role of the helical arch observed in varying con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::346ce6da1e0a771b6aab98697254a698

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The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations

Autor: Liu, R., Qiu, J.Z., Finger, L.D., Zheng, L., Shen, B.H.

Flap endonuclease-1 (FEN-1) is a structure-specific nuclease best known for its involvement in RNA primer removal and long-patch base excision repair. This enzyme is known to possess 5′-flap endo- (FEN) and 5′–3′ exo- (EXO) nuclease activitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::1585ffba54f03d818e91e78cdcf5f7f5

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