Pore-modulating toxins exploit inherent slow inactivation to block K⁺ channels

Autor: Karbat, Izhar, Altman-Gueta, Hagit, Fine, Shachar, Szanto, Tibor, Hamer-Rogotner, Shelly, Dym, Orly, Frolow, Felix, Gordon, Dalia, Panyi, Gyorgy, Gurevitz, Michael, Reuveny, Eitan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2019 Sep 01. 116(37), 18700-18709.

Externí odkaz: https://www.jstor.org/stable/26851961

Reduced activity of GIRK1‐containing heterotetramers is sufficient to affect neuronal functions, including synaptic plasticity and spatial learning and memory.

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Publikováno v: Journal of Physiology; Jan2021, Vol. 599 Issue 2, p521-545, 25p

Trimming the disordered C-terminal extension of the protease inhibitor Hg1 produces a potent Kv1.3 blocker

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Pore-modulating toxins exploit inherent slow inactivation to block K ⁺ channels.

Autor: Karbat I; Department of Biomolecular Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel., Altman-Gueta H; Department of Plant Molecular Biology and Ecology, Tel-Aviv University, 69978 Tel-Aviv, Israel., Fine S; Department of Biomolecular Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel., Szanto T; Department of Biophysics and Cell Biology, University of Debrecen, 4032 Debrecen, Hungary., Hamer-Rogotner S; Structural Proteomic Unit, Weizmann Institute of Science, 76100 Rehovot, Israel., Dym O; Structural Proteomic Unit, Weizmann Institute of Science, 76100 Rehovot, Israel., Frolow F; Department of Plant Molecular Biology and Ecology, Tel-Aviv University, 69978 Tel-Aviv, Israel., Gordon D; Department of Biomolecular Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel., Panyi G; Department of Biophysics and Cell Biology, University of Debrecen, 4032 Debrecen, Hungary., Gurevitz M; Department of Plant Molecular Biology and Ecology, Tel-Aviv University, 69978 Tel-Aviv, Israel., Reuveny E; Department of Biomolecular Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel; e.reuveny@weizmann.ac.il.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Sep 10; Vol. 116 (37), pp. 18700-18709. Date of Electronic Publication: 2019 Aug 23.