CD38 in SLE CD4 T cells promotes Ca ²⁺ flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface membrane.

Autor: Katsuyama E; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA., Humbel M; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA., Suarez-Fueyo A; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA., Satyam A; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA., Yoshida N; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA., Kyttaris VC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA., Tsokos MG; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA., Tsokos GC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA. gtsokos@bidmc.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8304. Date of Electronic Publication: 2024 Sep 27.

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

Autor: Finco, T S, Nantermet, P V, Baldwin, A S, Beg, A A

Nuclear factor kappa B (NF-kappa B) is a critical regulator of several genes which are involved in immune and inflammation responses. NF-kappa B, consisting of a 50-kDa protein (p50) and a 65-kDa protein (p65), is bound to a cytoplasmic retention pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5465214904d5c830375f8d584073fb4

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation.

Autor: Finco, T S, Westwick, J K, Norris, J L, Beg, A A, Der, C J, Baldwin, A S

Publikováno v: Journal of Biological Chemistry; September 1997, Vol. 272 Issue: 39 p24113-6, 4p

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.

Autor: Finco, T S, Beg, A A, Baldwin, A S

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; December 1994, Vol. 91 Issue: 25 p11884-11888, 5p

Pharmacokinetics of 2',3'-dideoxyinosine in monkeys

Autor: Qian, M X, Finco, T S, Swagler, A R, Gallo, J M

Publikováno v: Antimicrobial Agents and Chemotherapy; June 1991, Vol. 35 Issue: 6 p1247-1249, 3p