Identification of a potent anti-IL-15 antibody with opposing mechanisms of action in vitro and in vivo.

Autor: Finch, DK¹, Midha, A², Buchanan, CL¹, Cochrane, D¹, Craggs, RI², Cruwys, S², Grahames, C², Kolbeck, R³, Lowe, DC¹, Maltby, J², Pattison, DV¹, Vousden, KA¹, Ward, A², Sleeman, MA¹, Mallinder, PR², Finch, D K¹ (AUTHOR), Buchanan, C L (AUTHOR), Craggs, R I (AUTHOR), Lowe, D C (AUTHOR), Pattison, D V (AUTHOR)

Publikováno v: British Journal of Pharmacology. Jan2011, Vol. 162 Issue 2, p480-490. 11p. 7 Graphs.

Heterogeneity in 10-year course trajectories of moderate to severe major depressive disorder among veterans.

Autor: Panaite V; Research & Development Service, James A. Haley Veterans' Hospital, Tampa, FL, USA.; Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA., Luther SL; Research & Development Service, James A. Haley Veterans' Hospital, Tampa, FL, USA.; College of Public Health, University of South Florida, Tampa, FL, USA., Finch DK; Research & Development Service, James A. Haley Veterans' Hospital, Tampa, FL, USA., Cohen NJ; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schultz SK; Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA.; Mental Health and Behavioral Sciences, James A. Haley Veterans' Hospital, Tampa, FL, USA., Tsalatsanis A; Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA., Pfeiffer PN; VA Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA.

Publikováno v: Epidemiology and psychiatric sciences [Epidemiol Psychiatr Sci] 2024 Nov 13; Vol. 33, pp. e67. Date of Electronic Publication: 2024 Nov 13.

Predictability of B cell clonal persistence and immunosurveillance in breast cancer.

Autor: Sammut SJ; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. stephen-john.sammut@icr.ac.uk.; The Royal Marsden Hospital NHS Foundation Trust, London, UK. stephen-john.sammut@icr.ac.uk., Galson JD; Alchemab Therapeutics, Whittlesford, UK., Minter R; Alchemab Therapeutics, Whittlesford, UK., Sun B; Wellcome Centre for Human Genetics, Oxford, UK.; Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK., Chin SF; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., De Mattos-Arruda L; IrsiCaixa, Germans Trias i Pujol University Hospital, Badalona, Spain.; Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain., Finch DK; Alchemab Therapeutics, Whittlesford, UK., Schätzle S; Alchemab Therapeutics, Whittlesford, UK., Dias J; Alchemab Therapeutics, Whittlesford, UK., Rueda OM; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Seoane J; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Institució Catalana de Recerca i Estudis Avançats (ICREA), Universitat Autònoma de Barcelona (UAB), CIBERONC, Barcelona, Spain., Osbourn J; Alchemab Therapeutics, Whittlesford, UK., Caldas C; School of Clinical Medicine, University of Cambridge, Cambridge, UK. cc234@cam.ac.uk., Bashford-Rogers RJM; Wellcome Centre for Human Genetics, Oxford, UK. rachael.bashford-rogers@bioch.ox.ac.uk.; Department of Biochemistry, University of Oxford, Oxford, UK. rachael.bashford-rogers@bioch.ox.ac.uk.; Oxford Cancer Centre, Oxford, UK. rachael.bashford-rogers@bioch.ox.ac.uk.

Publikováno v: Nature immunology [Nat Immunol] 2024 May; Vol. 25 (5), pp. 916-924. Date of Electronic Publication: 2024 May 02.

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.

Autor: Roy A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Shi L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Encodia Inc, 5785 Oberlin Drive, San Diego, CA, 92121, USA., Chang A; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Dong X; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA.; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, Nanjing, China., Fernandez A; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA., Kraft JC; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Li J; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA., Le VQ; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA., Winegar RV; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Cherf GM; Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.; Denali Therapeutics, South San Francisco, CA, USA., Slocum D; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA., Poulson PD; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Casper GE; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Vallecillo-Zúniga ML; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Valdoz JC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA., Miranda MC; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Bai H; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Kipnis Y; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA., Olshefsky A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA., Priya T; Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Carter L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Ravichandran R; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Chow CM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Johnson MR; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Cheng S; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Smith M; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Overed-Sayer C; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Finch DK; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Alchemab Therapeutics Ltd, Cambridge, UK., Lowe D; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Evox Therapeutics Limited, Oxford Science Park, Medawar Centre, East Building, Robert Robinson Avenue, Oxford, OX4 4HG, England., Bera AK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Matute-Bello G; Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, USA., Birkland TP; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA., DiMaio F; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Raghu G; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.; Dept of Medicine, University of Washington, Seattle, WA, USA., Cochran JR; Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA., Stewart LJ; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA., Campbell MG; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA. melody@fredhutch.org., Van Ry PM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA. pvanry@byu.edu., Springer T; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA. springer@crystal.harvard.edu., Baker D; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA. dabaker@uw.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 13; Vol. 14 (1), pp. 5660. Date of Electronic Publication: 2023 Sep 13.

Complementary and Integrative Health Approaches and Pain Care Quality in the Veterans Health Administration Primary Care Setting: A Quasi-Experimental Analysis.

Autor: Han L; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbdities and Education (PRIME) Center, West Haven, CT, USA., Luther SL; James A. Haley Veterans Hospital, Tampa, FL, USA.; University of South Florida, College of Public Health, Tampa, FL, USA., Finch DK; James A. Haley Veterans Hospital, Tampa, FL, USA., Dobscha SK; Oregon Health and Science University, Portland, OR, USA.; VA Portland Health Care System, Portland, OR, USA., Skanderson M; VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbdities and Education (PRIME) Center, West Haven, CT, USA., Bathulapalli H; VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbdities and Education (PRIME) Center, West Haven, CT, USA., Fodeh SJ; VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbdities and Education (PRIME) Center, West Haven, CT, USA.; Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA., Hahm B; James A. Haley Veterans Hospital, Tampa, FL, USA., Bouayad L; James A. Haley Veterans Hospital, Tampa, FL, USA.; Florida International University, Miami, FL, USA., Lee A; VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbdities and Education (PRIME) Center, West Haven, CT, USA., Goulet JL; VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbdities and Education (PRIME) Center, West Haven, CT, USA.; Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA., Brandt CA; VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbdities and Education (PRIME) Center, West Haven, CT, USA.; Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA., Kerns RD; VA Connecticut Healthcare System, Pain Research, Informatics, Multimorbdities and Education (PRIME) Center, West Haven, CT, USA.; Departments of Psychiatry, Neurology and Psychology, Yale University, New Haven, CT, USA.

Publikováno v: Journal of integrative and complementary medicine [J Integr Complement Med] 2023 Jun-Jul; Vol. 29 (6-7), pp. 420-429. Date of Electronic Publication: 2023 Mar 27.