Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Filomena Sica"'
Autor:
Rosanna Culurciello, Ilaria Di Nardo, Andrea Bosso, Francesca Tortora, Romualdo Troisi, Filomena Sica, Angela Arciello, Eugenio Notomista, Elio Pizzo
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e24556- (2024)
Human angiogenin (hANG) is the most studied stress-induced ribonuclease (RNase). In physiological conditions it performs its main functions in nucleoli, promoting cell proliferation by rDNA transcription, whereas it is strongly limited by its inhibit
Externí odkaz:
https://doaj.org/article/b23113ca23a04c4199aeae3934dd997b
Autor:
Romualdo Troisi, Filomena Sica
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4279 (2024)
As a follow-up to the previous Special Issue “Aptamers: Functional-Structural Studies and Biomedical Applications” [...]
Externí odkaz:
https://doaj.org/article/ce4b1fbc276c4dc08318b8b2137b8299
Autor:
Romualdo Troisi, Claudia Riccardi, Kévan Pérez de Carvasal, Michael Smietana, François Morvan, Pompea Del Vecchio, Daniela Montesarchio, Filomena Sica
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 585-594 (2022)
Despite their unquestionable properties, oligonucleotide aptamers display some drawbacks that continue to hinder their applications. Several strategies have been undertaken to overcome these weaknesses, using thrombin binding aptamers as proof-of-con
Externí odkaz:
https://doaj.org/article/c189695b734244dea0cf4655a5106d10
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16318 (2023)
Aptamers are synthetic nucleic acids that are developed to target with high affinity and specificity chemical entities ranging from single ions to macromolecules and present a wide range of chemical and physical properties. Their ability to selective
Externí odkaz:
https://doaj.org/article/d23f40059d4e4a9cb24ac08913da58bb
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 863-871 (2021)
Post-SELEX modification of DNA aptamers is an established strategy to improve their affinity or inhibitory characteristics. In this study, we examined the possibility of increasing the recognition interface between the thrombin-binding aptamer HD1 (T
Externí odkaz:
https://doaj.org/article/a927f2a477124b85949f467fddc464f7
Autor:
Rosanna Culurciello, Andrea Bosso, Romualdo Troisi, Valentina Barrella, Ilaria Di Nardo, Margherita Borriello, Rosa Gaglione, Valeria Pistorio, Serena Aceto, Valeria Cafaro, Eugenio Notomista, Filomena Sica, Angela Arciello, Elio Pizzo
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8781 (2022)
Human angiogenin (ANG) is a 14-kDa ribonuclease involved in different pathophysiological processes including tumorigenesis, neuroprotection, inflammation, innate immunity, reproduction, the regeneration of damaged tissues and stress cell response, de
Externí odkaz:
https://doaj.org/article/effb899789d04cbb94b94cf5fb6ee9ee
Autor:
Romualdo Troisi, Filomena Sica
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4796 (2022)
Aptamers are synthetic molecules of different natures (mostly, DNA or RNA) that recognize a target molecule with high affinity and specificity [...]
Externí odkaz:
https://doaj.org/article/b4ef6327272d4fddabf70f9bfc5ea58a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10803 (2021)
Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both procoagulant and anticoagulant functions; therefore, it represents an attractive target for the developments of biomolecules with therapeutic potential. Thromb
Externí odkaz:
https://doaj.org/article/4cb062739416417c858a340dbe58e3cd
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 6, Pp 11643-11691 (2013)
The elucidation of the three dimensional structure of biological macromolecules has provided an important contribution to our current understanding of many basic mechanisms involved in life processes. This enormous impact largely results from the abi
Externí odkaz:
https://doaj.org/article/f08149596b4d4f3d94bb80052b54cc55
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 3, Pp 3782-3800 (2012)
Serum albumin is one of the most widely studied proteins. It is the most abundant protein in plasma with a typical concentration of 5 g/100 mL and the principal transporter of fatty acids in plasma. While the crystal structures of human serum albumin
Externí odkaz:
https://doaj.org/article/7ce28cde40e249c3887d7d36db2bc733