Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Filomena Broeskamp"'
Autor:
Katharina S. Keuenhof, Verena Kohler, Filomena Broeskamp, Dimitra Panagaki, Sean D. Speese, Sabrina Büttner, Johanna L. Höög
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTThe nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport. However, it has also been known th
Externí odkaz:
https://doaj.org/article/4b7bb68c77f04a0bb213452995631ac2
Autor:
Jack Davis, Thorsten Meyer, Martin Smolnig, Daniel G.J. Smethurst, Lisa Neuhaus, Jonas Heyden, Filomena Broeskamp, Elizabeth S.M. Edrich, Oskar Knittelfelder, Dagmar Kolb, Tobias von der Haar, Campbell W. Gourlay, Patrick Rockenfeller
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107539- (2023)
Summary: The dynamic nature of the actin cytoskeleton is required to coordinate many cellular processes, and a loss of its plasticity has been linked to accelerated cell aging and attenuation of adaptive response mechanisms. Cofilin is an actin-bindi
Externí odkaz:
https://doaj.org/article/be50f411dace449ba5f7ff725e47e81c
Autor:
Jutta Diessl, Jens Berndtsson, Filomena Broeskamp, Lukas Habernig, Verena Kohler, Carmela Vazquez-Calvo, Arpita Nandy, Carlotta Peselj, Sofia Drobysheva, Ludovic Pelosi, F.-Nora Vögtle, Fabien Pierrel, Martin Ott, Sabrina Büttner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Across phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesis
Externí odkaz:
https://doaj.org/article/4dc9625ee56c416c8681a2d756ae7db0
Autor:
Julia Ring, Jelena Tadic, Selena Ristic, Michael Poglitsch, Martina Bergmann, Nemanja Radic, Dirk Mossmann, YongTian Liang, Marta Maglione, Andrea Jerkovic, Roozbeh Hajiraissi, Marcel Hanke, Victoria Küttner, Heimo Wolinski, Andreas Zimmermann, Lana Domuz Trifunović, Leonie Mikolasch, Daiana N Moretti, Filomena Broeskamp, Julia Westermayer, Claudia Abraham, Simon Schauer, Christopher Dammbrueck, Sebastian J Hofer, Mahmoud Abdellatif, Guido Grundmeier, Guido Kroemer, Ralf J Braun, Niklas Hansen, Cornelia Sommer, Mirjana Ninkovic, Sandra Seba, Patrick Rockenfeller, Friederike‐Nora Vögtle, Jörn Dengjel, Chris Meisinger, Adrian Keller, Stephan J Sigrist, Tobias Eisenberg, Frank Madeo
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp n/a-n/a (2022)
Abstract Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic approach using a yeast m
Externí odkaz:
https://doaj.org/article/4c65d2eea54842d29ae6240b593bf7ff
Autor:
Carlotta Peselj, Mahsa Ebrahimi, Filomena Broeskamp, Simon Prokisch, Lukas Habernig, Irene Alvarez-Guerra, Verena Kohler, F.-Nora Vögtle, Sabrina Büttner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Nutrient starvation initiates cell cycle exit and entry into quiescence, a reversible, non-proliferative state characterized by stress tolerance, longevity and large-scale remodeling of subcellular structures. Depending on the nature of the depleted
Externí odkaz:
https://doaj.org/article/4d0b1f8ac67b4bb5acd059d5aa24532d
Autor:
Lukas Habernig, Filomena Broeskamp, Andreas Aufschnaiter, Jutta Diessl, Carlotta Peselj, Elisabeth Urbauer, Tobias Eisenberg, Ana de Ory, Sabrina Büttner
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009911 (2021)
The capacity of a cell to maintain proteostasis progressively declines during aging. Virtually all age-associated neurodegenerative disorders associated with aggregation of neurotoxic proteins are linked to defects in the cellular proteostasis networ
Externí odkaz:
https://doaj.org/article/3275e960d02c424789ab4ab1a2d49e6a
Autor:
Mahsa Ebrahimi, Lukas Habernig, Filomena Broeskamp, Andreas Aufschnaiter, Jutta Diessl, Isabel Atienza, Steffen Matz, Felix A. Ruiz, Sabrina Büttner
Publikováno v:
Cells, Vol 10, Iss 11, p 3161 (2021)
Nutrient limitation results in an activation of autophagy in organisms ranging from yeast, nematodes and flies to mammals. Several evolutionary conserved nutrient-sensing kinases are critical for efficient adaptation of yeast cells to glucose, nitrog
Externí odkaz:
https://doaj.org/article/66272d53b3b0473b863a7fdb23b8b284
Autor:
Filomena Broeskamp, Elizabeth S. M. Edrich, Oskar Knittelfelder, Lisa Neuhaus, Thorsten Meyer, Jonas Heyden, Lukas Habernig, Florian Kreppel, Campbell W. Gourlay, Patrick Rockenfeller
Publikováno v:
Cells, Vol 10, Iss 9, p 2416 (2021)
Autophagy is a cellular recycling program which efficiently reduces the cellular burden of ageing. Autophagy is characterised by nucleation of isolation membranes, which grow in size and further expand to form autophagosomes, engulfing cellular mater
Externí odkaz:
https://doaj.org/article/1a6f54ffecae44a8a599bd8710dcc9dc
Autor:
Irene Álvarez-Guerra, Emma Block, Filomena Broeskamp, Sonja Gabrijelčič, Ana de Ory, Lukas Habernig, Claes Andréasson, Tim P. Levine, Johanna L. Höög, Sabrina Büttner
SummaryLipid droplets (LDs) are fat storage organelles critical for energy and lipid metabolism. Upon nutrient exhaustion, cells consume LDs via gradual lipolysis or via lipophagy, theen blocuptake of LDs into the vacuole. Here, we show that LDs dock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b26680096546e5f072dd1c6d746267b
https://doi.org/10.1101/2023.04.21.537797
https://doi.org/10.1101/2023.04.21.537797
Autor:
Jack Davis, Thorsten Meyer, Daniel Smethurst, Lisa Neuhaus, Jonas Heyden, Filomena Broeskamp, Elizabeth Edrich, Oskar Knittelfelder, Martin Smolnig, Dagmar Kolb, Tobias von der Haar, Campbell Gourlay, Patrick Rockenfeller
The dynamic nature of the actin cytoskeleton controls many cellular processes and a loss of its plasticity has been linked to accelerated cell ageing. Cofilin is an actin-binding protein that controls actin dynamics and is linked to mitochondrial sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a7827dc0b044b11cbabe91ab4228d1e
https://doi.org/10.21203/rs.3.rs-2305879/v1
https://doi.org/10.21203/rs.3.rs-2305879/v1