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Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound.

Autor: Millar JR; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Bengu N; Umkhuseli Innovation and Research Management, Pietermaritzburg, South Africa., Vieira VA; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Adland E; Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Roider J; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Africa Health Research Institute, Durban, South Africa.; German Center for Infection Research, Munich,Germany.; Department of Infectious Diseases, Ludwig Maximilian University, Munich, Germany., Muenchhoff M; German Center for Infection Research, Munich,Germany.; Max von Pettenkofer Institute, Virology, National Reference Center for Retroviruses, Faculty of Medicine, Ludwig Maximilian University, Munich, Germany., Fillis R; Umkhuseli Innovation and Research Management, Pietermaritzburg, South Africa., Sprenger K; Umkhuseli Innovation and Research Management, Pietermaritzburg, South Africa., Ntlantsana V; School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Fatti I; Umkhuseli Innovation and Research Management, Pietermaritzburg, South Africa., Archary M; Department of Paediatrics, King Edward VIII Hospital/University of KwaZulu-Natal, Durban, South Africa., Groll A; Technical University Dortmund, Department of Statistics, Dortmund, Germany., Ismail N; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa., García-Guerrero MC; IrsiCaixa AIDS Research Institute, Badalona, Spain., Matthews PC; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Department of Microbiology and Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom., Ndung'u T; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute, Durban, South Africa.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, Massachusetts, USA.; Max Planck Institute for Infection Biology, Berlin, Germany.; Division of Infection and Immunity, University College London, London, United Kingdom., Puertas MC; IrsiCaixa AIDS Research Institute, Badalona, Spain., Martinez-Picado J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; University of Vic-Central University of Catalonia, Vic, Spain.; Catalan Institution for Research and Advanced Studies, Barcelona, Spain.; Germans Trias i Pujol Research Institute, Badalona, Spain., Goulder P; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, Massachusetts, USA.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2021 Dec 01; Vol. 224 (11), pp. 1925-1934.