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Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.

Autor: Harjes S; School of Natural Sciences, Massey University, Palmerston North, New Zealand., Kurup HM; School of Natural Sciences, Massey University, Palmerston North, New Zealand., Rieffer AE; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN, USA., Bayaijargal M; School of Natural Sciences, Massey University, Palmerston North, New Zealand.; Current address: Department of Biochemistry, University of Washington, Seattle, WA, USA., Filitcheva J; School of Natural Sciences, Massey University, Palmerston North, New Zealand., Su Y; School of Natural Sciences, Massey University, Palmerston North, New Zealand.; Current address: Department of Pediatrics, Emory University School of Medicine, and the Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Hale TK; School of Natural Sciences, Massey University, Palmerston North, New Zealand., Filichev VV; School of Natural Sciences, Massey University, Palmerston North, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand., Harjes E; School of Natural Sciences, Massey University, Palmerston North, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand., Harris RS; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX, USA.; Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, TX, USA., Jameson GB; School of Natural Sciences, Massey University, Palmerston North, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 17. Date of Electronic Publication: 2023 Feb 17.