Výsledky vyhledávání - "Filippos Porichis"

Akademický článek

Increased frequencies of CD8+CD57+ T cells are associated with antibody neutralization breadth against HIV in viraemic controllers

Autor: Christine D Palmer, Marisol Romero‐Tejeda, Eileen P Scully, Ainsley Lockhart, Michael S Seaman, Ariel Goldenthal, Alicja Piechocka‐Trocha, Bruce D Walker, Lori B Chibnik, Stephanie Jost, Filippos Porichis

Publikováno v: Journal of the International AIDS Society, Vol 19, Iss 1, Pp n/a-n/a (2016)

Introduction An effective prophylactic vaccine against HIV will need to elicit antibody responses capable of recognizing and neutralizing rapidly evolving antigenic regions. The immunologic milieu associated with development of neutralizing antibody

Externí odkaz: https://doaj.org/article/d25e8f87343f4fc2a2332b20cbbdf296

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Akademický článek

Co-infection with Mycobacterium tuberculosis impairs HIV-Specific CD8+ and CD4+ T cell functionality.

Autor: Shivan Chetty, Pamla Govender, Jennifer Zupkosky, Mona Pillay, Musie Ghebremichael, Mahomed-Yunus S Moosa, Thumbi Ndung'u, Filippos Porichis, Victoria O Kasprowicz

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0118654 (2015)

The ability of antigen-specific T cells to simultaneously produce multiple cytokines is thought to correlate with the functional capacity and efficacy of T cells. These 'polyfunctional' T cells have been associated with control of HIV. We aimed to as

Externí odkaz: https://doaj.org/article/cb61abca59ac489e8ce4f9e744ec9faf

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Discovery of HPK1 Inhibitors with High Cellular Potency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60c4b42c55d861e189da387afa4d82a1
https://doi.org/10.2139/ssrn.4382746

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Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique

Autor: Marta Massanella, Jonathan Richard, Nirmin Alsahafi, Daniel Kaufmann, Nicolas Chomont, Filippos Porichis, Amy E. Baxter, Jean-Pierre Routy, Nathalie Brassard, Julia Niessl, Rémi Fromentin, Andrés Finzi

Publikováno v: Nature Protocols. 12:2029-2049

HIV cure efforts are hampered by limited characterization of the cells supporting HIV replication in vivo and inadequate methods for quantifying the latent viral reservoir in individuals receiving antiretroviral therapy. We describe a protocol for fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c60f698ba27eb09bb191ac347aad08e
https://doi.org/10.1038/nprot.2017.079

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Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef

Autor: Amy Sbrolla, Anna P. McLean, Rajesh T. Gandhi, Bruce D. Walker, Nicole McBrine, Douglas S. Kwon, Filippos Porichis, Janet Shopis, Dan H. Barouch, Lauren Peter, Theresa Flynn, Nina Bhardwaj, Daniel G. Kavanagh, Eric A. Macklin, Daniel Kaufmann

Publikováno v: Journal of Acquired Immune Deficiency Syndromes (1999)

Background: HIV-1 eradication may require reactivation of latent virus along with stimulation of HIV-1-specific immune responses to clear infected cells. Immunization with autologous dendritic cells (DCs) transfected with viral mRNA is a promising st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc802d3e69c86fd58b4c5734e16d2020
https://doi.org/10.1097/qai.0000000000000852

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HIV and SIV, CD4 T-Cell Responses to

Autor: Filippos Porichis, Daniel E. Kaufmann

Publikováno v: Encyclopedia of AIDS ISBN: 9781461496106

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1f03fd58cccdfb49a5a9e607dcb752
https://doi.org/10.1007/978-1-4939-7101-5_184

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Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells

Autor: Alexandra Massa, Holly L. Everett, Jonathan Richard, Andrés Finzi, Meghan G. Hart, Gordon J. Freeman, Daniel E. Kaufmann, Nathalie Brassard, Maxime Veillette, Muska Hassan, Jean-Pierre Routy, Ngoc L. Ly, Filippos Porichis, Mathieu Dubé, Antigoni Morou

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 201(3)

Immune exhaustion is an important feature of chronic infections, such as HIV, and a barrier to effective immunity against cancer. This dysfunction is in part controlled by inhibitory immune checkpoints. Blockade of the PD-1 or IL-10 pathways can rein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a894c69b075e535af1bf4fc764a5fd
https://pubmed.ncbi.nlm.nih.gov/29934472

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HIV controllers exhibit enhanced frequencies of major histocompatibility complex class II tetramer+ Gag-specific CD4+ T cells in chronic clade C HIV-1 infection

Autor: Faatima Laher, Mary Carrington, Anette Stryhn, Zaza M. Ndhlovu, Bruce D. Walker, Filippos Porichis, Srinika Ranasinghe, Nasreen Ismail, Søren Buus, Thumbi Ndung'u, Karyn Pretorius, Nikoshia Mewalal

Publikováno v: Laher, F, Ranasinghe, S, Porichis, F, Mewalal, N, Pretorius, K, Ismail, N, Buus, S, Stryhn, A, Carrington, M, Walker, B D, Ndung'u, T & Ndhlovu, Z M 2017, ' HIV controllers exhibit enhanced frequencies of major histocompatibility complex class II tetramer + Gag-specific CD4 + T cells in chronic clade C HIV-1 infection ', Journal of Virology, vol. 91, no. 7, e02477-16 . https://doi.org/10.1128/JVI.02477-16
Journal of Virology

Immune control of viral infections is heavily dependent on helper CD4 + T cell function. However, the understanding of the contribution of HIV-specific CD4 + T cell responses to immune protection against HIV-1, particularly in clade C infection, rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a404fb8114b35826dc10d968bd81ef78
https://curis.ku.dk/portal/da/publications/hiv-controllers-exhibit-enhanced-frequencies-of-major-histocompatibility-complex-class-ii-tetramer-gagspecific-cd4-t-cells-in-chronic-clade-c-hiv1-infection(54c9f616-a68a-4fe7-a16f-a07d8c323695).html

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