Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Filippos Kesisoglou"'
Autor:
Fang Wu, Youssef Mousa, Kimberly Raines, Chris Bode, Yu Chung Tsang, Rodrigo Cristofoletti, Hongling Zhang, Tycho Heimbach, Lanyan Fang, Filippos Kesisoglou, Amitava Mitra, James Polli, Myong‐Jin Kim, Jianghong Fan, Banu S. Zolnik, Duxin Sun, Yi Zhang, Liang Zhao
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 585-597 (2023)
Abstract This report summarizes the proceedings for day 2 sessions 1 and 3 of the 2‐day public workshop entitled “Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence Approaches,” a jointly sponsored workshop by the
Externí odkaz:
https://doaj.org/article/bff355b182e94d38a6b888911c0d4a2e
Autor:
Paul van den Berg, Wei Gao, Maurice J. Ahsman, Leticia Arrington, Filippos Kesisoglou, Randy Miller, Teun M. Post, Matthew L. Rizk
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 658-670 (2021)
Abstract Uprifosbuvir is a uridine nucleoside monophosphate prodrug inhibitor of the hepatitis C virus NS5B RNA polymerase. To quantitatively elucidate key metabolic pathways, assess the link between unmeasurable effect site concentrations and viral
Externí odkaz:
https://doaj.org/article/5efa895ab7f349ba8e6d77672c190469
Publikováno v:
Pharmaceutical Research. 40:419-429
To date, mechanistic modeling of oral drug absorption has been achieved via the use of physiologically based pharmacokinetic (PBPK) modeling, and more specifically, physiologically based biopharmaceutics model (PBBM). The concept of finite absorption
Dose Number as a Tool to Guide Lead Optimization for Orally Bioavailable Compounds in Drug Discovery
Autor:
W. Peter Wuelfing, Abdellatif El Marrouni, Maya P. Lipert, Pierre Daublain, Filippos Kesisoglou, Antonella Converso, Allen C. Templeton
Publikováno v:
Journal of Medicinal Chemistry. 65:1685-1694
Small molecule developability challenges have been well documented over the last two decades. One of these critical developability parameters is aqueous solubility. In general, more soluble compounds have improved oral absorption. While enabling form
Autor:
Matthew L. Rizk, Paul van den Berg, Maurice J. Ahsman, Teun M. Post, Leticia Arrington, Filippos Kesisoglou, Wei Gao, Randy R. Miller
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 7, Pp 658-670 (2021)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Uprifosbuvir is a uridine nucleoside monophosphate prodrug inhibitor of the hepatitis C virus NS5B RNA polymerase. To quantitatively elucidate key metabolic pathways, assess the link between unmeasurable effect site concentrations and viral load redu
Autor:
Marilyn N. Martinez, Fang Wu, Balint Sinko, David J. Brayden, Michael Grass, Filippos Kesisoglou, Aaron Stewart, Kiyohiko Sugano
Publikováno v:
The AAPS Journal. 24
It is now recognized that a number of excipients previously considered to be "inert" have the capacity to alter drug oral bioavailability through a range of in vivo effects. The various mechanisms through which an excipient can affect in vivo gastroi
Autor:
Erik Sjögren, James Butler, Vidula Kolhatkar, Xavier Pepin, Lynne S. Taylor, Andrew Babiskin, Sandra Suarez-Sharp, Paul Seo, Jennifer B. Dressman, Christer Tannergren, André Dallmann, Xinyuan Zhang, Poonam Delvadia, Edmund Kostewicz, Yang Zhao, Amitava Mitra, Filippos Kesisoglou, Mirko Koziolek, Neil Parrott
Publikováno v:
Journal of Pharmaceutical Sciences. 110:567-583
This workshop report summarizes the proceedings of Day 1 of a three-day workshop on “Current State and Future Expectations of Translational Modeling Strategies to Support Drug Product Development, Manufacturing Changes and Controls”. Physiologica
Publikováno v:
International Journal of Pharmaceutics. 635:122758
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3471-3479
The physiological pH changes and peristalsis activities in gastrointestinal (GI) tract have big impact on the dissolution of oral drug products, when those oral drug products include APIs with pH-dependent solubility. It is well documented that predi
Autor:
Aktham, Aburub, Yuan, Chen, John, Chung, Ping, Gao, David, Good, Simone, Hansmann, Michael, Hawley, Tycho, Heimbach, Martin, Hingle, Filippos, Kesisoglou, Rong, Li, John, Rose, Christophe, Tisaert
Publikováno v:
The AAPS Journal. 24
Assessment of bioperformance to inform formulation selection and development decisions is an important aspect of drug development. There is high demand in the pharmaceutical industry to develop an efficient and streamlined approach for better underst