Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Filippo Sladojevich"'
Autor:
Nazarii Sabat, Andreas Stämpfli, Steven Hanlon, Serena Bisagni, Filippo Sladojevich, Kurt Püntener, Marcel Hollenstein
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Chemical modification of DNA is a common strategy to improve the properties of oligonucleotides, particularly for therapeutics and nanotechnology. Existing synthetic methods essentially rely on phosphoramidite chemistry or the polymerization
Externí odkaz:
https://doaj.org/article/489e2deef59d4c8ea3367084c2bf857e
Autor:
Marie Flamme, Steven Hanlon, Irene Marzuoli, Kurt Püntener, Filippo Sladojevich, Marcel Hollenstein
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-12 (2022)
Controlled enzymatic DNA synthesis represents an alternative synthetic methodology that circumvents the limitations of traditional soild-phase synthesis. Here, the authors explore the use of 3’-phosphate as a transient protecting group for the cont
Externí odkaz:
https://doaj.org/article/f8dffe1d56d24661a896a0d6fbbd77d3
Autor:
Nazarii Sabat, Dace Katkevica, Karlis Pajuste, Marie Flamme, Andreas Stämpfli, Martins Katkevics, Steven Hanlon, Serena Bisagni, Kurt Püntener, Filippo Sladojevich, Marcel Hollenstein
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Enzymatic, de novo XNA synthesis represents an alternative method for the production of long oligonucleotides containing chemical modifications at distinct locations. While such an approach is currently developed for DNA, controlled enzymatic synthes
Externí odkaz:
https://doaj.org/article/9b2b3d084b7e48e9b531540bf44bec58
Autor:
Eric-André Kusznir, Jean-Christophe Hau, Michaela Portmann, Anne-Gaëlle Reinhart, Fabio Falivene, Jessica Bastien, Jesper Worm, Alfred Ross, Matthias Lauer, Philippe Ringler, Filippo Sladojevich, Sylwia Huber, Konrad Bleicher, Michael Keller
Publikováno v:
Bioconjugate Chemistry. 34:866-879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b442ab932caa92dc32e3a2f57bf189a
https://doi.org/10.1021/acs.bioconjchem.3c00085
https://doi.org/10.1021/acs.bioconjchem.3c00085
Autor:
Katja Heinig, Filippo Sladojevich, Jeannine Petrig Schaffland, Georg Jaeschke, Alfred Ross, Philipp Koldewey, Saša M. Miladinović, Jin Wang, Caroline Rynn
Publikováno v:
Pharmaceutical Research. 39:653-667
Exploration of the chemical, analytical and pharmacokinetic properties of the API, RO7304898, an allosteric EGFR inhibitor, intended to be developed as a mixture of two rapidly interconverting diastereoisomers with composition ratio of approximately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a73e622a7a6ab994ee6fe51bf457a35
https://doi.org/10.1007/s11095-022-03234-w
https://doi.org/10.1007/s11095-022-03234-w
Autor:
Marie Flamme, Dace Katkevica, Karlis Pajuste, Martins Katkevics, Nazarii Sabat, Steven Hanlon, Irene Marzuoli, Kurt Püntener, Filippo Sladojevich, Marcel Hollenstein
Publikováno v:
Asian Journal of Organic Chemistry
Asian Journal of Organic Chemistry, 2022, 11 (10), pp.e202200384. ⟨10.1002/ajoc.202200384⟩
Asian Journal of Organic Chemistry, 2022, 11 (10), pp.e202200384. ⟨10.1002/ajoc.202200384⟩
International audience; Controlled enzymatic synthesis is an alluring alternative to solid-phase synthesis and polymerase-mediated incorporation of nucleotides for the crafting of chemically modified, therapeutic oligonucleotides. While this approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ab6e5655d1e62dbe8a834e09c60c1d
https://doi.org/10.1002/ajoc.202200384
https://doi.org/10.1002/ajoc.202200384
Autor:
Filippo Sladojevich, Remo Gamboni, Tanja Minz, Philippe Ringler, Rainer Alex, Sabine Kux van Geijtenbeek, Michaela Portmann, Axel Ducret, Matthias E. Lauer, Ravi Jagasia, Eric-André Kusznir, Bettina Nordbo, Sabine Sewing, Michael Keller, Nikhil J. Pandya, Erich Koller, Philip Grossen, Marco Berrera, Martina Brigitte Duschmalé, Sylwia Huber, Marianne Lerbech Jensen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 158:198-210
The natural capacity of extracellular vesicles (EVs) to transport their payload to recipient cells has raised big interest to repurpose EVs as delivery vehicles for xenobiotics. In the present study, bovine milk-derived EVs (BMEVs) were investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d661697ef6bf27a8c7b0b3cba4f4e4
https://doi.org/10.1016/j.ejpb.2020.11.012
https://doi.org/10.1016/j.ejpb.2020.11.012
Autor:
Filippo Sladojevich, Marcel Hollenstein, Hans Iding, Kurt Puentener, Steven P. Hanlon, Marie Flamme
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2021, 48, pp.128242. ⟨10.1016/j.bmcl.2021.128242⟩
Bioorganic & Medicinal Chemistry Letters, 2021, 48, pp.128242. ⟨10.1016/j.bmcl.2021.128242⟩
International audience; Therapeutic oligonucleotides require the addition of multiple chemical modifications to the nucleosidic scaffold in order to improve their drug delivery efficiency, cell penetration capacity, biological stability, and pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb84cd0053d02fe006bab075a0b42ce
https://hal-pasteur.archives-ouvertes.fr/pasteur-03930950/file/Manuscript_thioLNA.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03930950/file/Manuscript_thioLNA.pdf
Autor:
Filippo Sladojevich, Sara Vanetti, Dario Neri, Samuele Cazzamalli, Jörg Scheuermann, Martina Bigatti, Ulrike Rieder, Alberto Dal Corso
Publikováno v:
ChemMedChem. 12:1748-1752
The screening of encoded self-assembling chemical libraries allows the identification of fragment pairs that bind to adjacent pockets on target proteins of interest. For practical applications, it is necessary to link these ligand pairs into discrete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d59d7fe56adf3443d575b2097cae8b4
https://doi.org/10.1002/cmdc.201700569
https://doi.org/10.1002/cmdc.201700569
Autor:
Pascal M. Rüefli, Roger Schibli, Selena Milicevic Sephton, Stefanie-Dorothea Krämer, Adrienne Müller Herde, Martin Lochner, Simon M. Ametamey, Linjing Mu, Andrew J. Thompson, Filippo Sladojevich
Publikováno v:
ACS Chemical Neuroscience
Serotonin gated ionotropic 5 HT3 receptors are the major pharmacological targets for antiemetic compounds. Furthermore they have become a focus for the treatment of irritable bowel syndrome (IBS) and there is some evidence that pharmacological modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d0e66f154ec4512ad8033be62fa91