A Simple Biosensor Based on Streptavidin-HRP for the Detection of Bacteria Exploiting HRPs Molecular Surface Properties

Autor: Filippo Savini, Natalie Mutter, Katja Baumgartner, Ivan Barišić

Publikováno v: Applied Biosciences, Vol 2, Iss 3, Pp 513-526 (2023)

Bacterial contamination of water and food sources is still a major source of diseases. Early detection of potential pathogens is key to prevent their spreading and severe health risks. Here, we describe a fast, low-cost detection assay based on horse

Externí odkaz: https://doaj.org/article/c16b57af45fc4226a8af391c2fa1a9d3

Inoculum effect of antimicrobial peptides

Autor: Bruno Casciaro, Filippo Savini, Sara Bobone, Henrik Franzyk, Maria Luisa Mangoni, Lorenzo Stella, Maria Rosa Loffredo

Publikováno v: Proc Natl Acad Sci U S A
Loffredo, M R, Savini, F, Bobone, S, Casciaro, B, Franzyk, H, Mangoni, M L & Stella, L 2021, ' Inoculum effect of antimicrobial peptides ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 21, e2014364118 . https://doi.org/10.1073/pnas.2014364118

The activity of many antibiotics depends on the initial density of cells used in bacteria growth inhibition assays. This phenomenon, termed the inoculum effect, can have important consequences for the therapeutic efficacy of the drugs, since bacteria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc67823ef6270ff73e234efde6f2454a
https://doi.org/10.1101/2020.08.21.260620

Guida curiosa di Cortina D'Ampezzo

Autor: Luca Barone, Stefano Capinera, Cendali Guido Pignatelli, Maria Filippo Savini

Natura e sport, escursioni e passeggiate, storia e tradizioni nella perla delle Dolomiti Chi ama la montagna ama Cortina d'Ampezzo. È uno dei luoghi più frequentati da alpinisti, sciatori e mountain biker, perché unisce la spettacolare collocazion

Enhancing the Antimicrobial Activity of Alamethicin F50/5 by Incorporating N-terminal Hydrophobic Triazole Substituents

Autor: Vanessa Andreu, Jean Martinez, Khoubaib Ben Haj Salah, Emmanuel Wenger, Sanjit Kumar Das, Claude Didierjean, Jules Kotarba, Baptiste Legrand, Nicolas Inguimbert, Filippo Savini, Lorenzo Stella, Nicolas Ruiz

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2017, 23 (71), pp.17964-17972. ⟨10.1002/chem.201703569⟩

We propose a simple and efficient strategy to significantly improve the antibacterial activity of peptaibols and other antimicrobial peptides by N-terminal capping with 1,2,3-triazole bearing various hydrophobic substituents on C-4. We showed, herein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f2fc2dc75f00699dc8593d8c2096ec
https://pubmed.ncbi.nlm.nih.gov/28922505

The Role of Thermodynamics in the Activity and Selectivity of Antimicrobial Peptides

Autor: Filippo Savini, Sara Bobone, Zahra Vaezi, Vincenzo Luca, Lorenzo Stella, Alessio Bocedi, A Farrotti, Daniela Roversi, Yoonkyung Park, Antonio Palleschi, Maria Luisa Mangoni, Gianfranco Bocchinfuso

Publikováno v: Biophysical Journal. 110:75a-76a

Antimicrobial peptides (AMPs) are natural bactericidals and immunomodulators, and their action involves association to cell membranes and their perturbation. In vitro, they are selective for bacteria versus eukaryotic cells. Although AMPs are promisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abddad2cc5f58df83a4042087449a8eb
https://doi.org/10.1016/j.bpj.2015.11.473