Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

Autor: Lola Bajard, Ondrej Adamovsky, Karine Audouze, Kirsten Baken, Robert Barouki, Joost B. Beltman, Anna Beronius, Eva Cecilie Bonefeld-Jørgensen, German Cano-Sancho, Milo L. de Baat, Filippo Di Tillio, Mariana F. Fernández, Rex E. FitzGerald, Claudia Gundacker, Antonio F. Hernández, Klara Hilscherova, Spyros Karakitsios, Eliska Kuchovska, Manhai Long, Mirjam Luijten, Sanah Majid, Philip Marx-Stoelting, Vicente Mustieles, Chander K. Negi, Dimosthenis Sarigiannis, Stefan Scholz, Iva Sovadinova, Rob Stierum, Shihori Tanabe, Knut Erik Tollefsen, Annick D. van den Brand, Carolina Vogs, Maria Wielsøe, Clemens Wittwehr, Ludek Blaha

Publikováno v: Environmental Research
Environmental Research. Elsevier BV
Bajard, L, Adamovsky, O, Audouze, K, Baken, K, Barouki, R, Beltman, J B, Beronius, A, Bonefeld-Jørgensen, E C, Cano-Sancho, G, de Baat, M L, Di Tillio, F, Fernández, M F, FitzGerald, R E, Gundacker, C, Hernández, A F, Hilscherova, K, Karakitsios, S, Kuchovska, E, Long, M, Luijten, M, Majid, S, Marx-Stoelting, P, Mustieles, V, Negi, C K, Sarigiannis, D, Scholtz, S, Sovadinova, I, Stierum, R, Tanabe, S, Tollefsen, K E, van den Brand, A D, Vogs, C, Wielsøe, M, Wittwehr, C & Blaha, L 2023, ' Application of AOPs to assist regulatory assessment of chemical risks-Case studies, needs and recommendations ', Environmental Research, vol. 217, 114650 . https://doi.org/10.1016/j.envres.2022.114650

While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human

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