Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Filippo De Simone"'
Autor:
Francisco Perez-Balderas, Sander I. van Kasteren, Alaa A. A. Aljabali, Kim Wals, Sébastien Serres, Andrew Jefferson, Manuel Sarmiento Soto, Alexandre A. Khrapitchev, James R Larkin, Claire Bristow, Seung Seo Lee, Guillaume Bort, Filippo De Simone, Sandra J. Campbell, Robin P. Choudhury, Daniel C. Anthony, Nicola R. Sibson, Benjamin G. Davis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Iron oxide microparticles (MPIO) are better MRI contrast agents than nanoparticles, but are of limited clinical use as they are not degradable and so risk toxicity. Here the authors present an iron oxide microparticle MRI contrast agent with peptide
Externí odkaz:
https://doaj.org/article/d6193834fc8f46f68e4a4160e6d4d903
Autor:
Filippo De Simone, Jérôme Waser
Publikováno v:
CHIMIA, Vol 66, Iss 4 (2012)
The continuous progress in medicinal chemistry requires more versatile synthetic strategies for the generation of large libraries of active compounds and their analogues. As a result, the research for new effective cyclization and cycloaddition react
Externí odkaz:
https://doaj.org/article/7b42ae031f9e43ef9af4ae1a68f1c9c3
Autor:
Davinia Fernández González, Filippo De Simone, Jonathan P. Brand, Stefano Nicolai, Jérôme Waser
Publikováno v:
CHIMIA, Vol 65, Iss 9 (2011)
One of the major challenges faced by organic chemistry is the efficient synthesis of increasingly complex molecules. Since October 2007, the Laboratory of Catalysis and Organic Synthesis (LCSO) at EPFL has been working on the development of catalytic
Externí odkaz:
https://doaj.org/article/9908bbe0218946618da1e5c0f215d1b2
Autor:
Filippo De Simone, Jérôme Waser
Publikováno v:
CHIMIA, Vol 63, Iss 3 (2009)
Ring strain confers exceptional reactivity to the cyclopropane ring. Nevertheless, activation of the cyclopropane ring is usually needed to allow ring-opening reactions under mild conditions. The introduction of one or several carbonyl functionalitie
Externí odkaz:
https://doaj.org/article/c7660221b32947de8bbec46f27d1026a
Autor:
Francisco, Perez-Balderas, Sander I, van Kasteren, Alaa A A, Aljabali, Kim, Wals, Sébastien, Serres, Andrew, Jefferson, Manuel, Sarmiento Soto, Alexandre A, Khrapitchev, James R, Larkin, Claire, Bristow, Seung Seo, Lee, Guillaume, Bort, Filippo, De Simone, Sandra J, Campbell, Robin P, Choudhury, Daniel C, Anthony, Nicola R, Sibson, Benjamin G, Davis
Publikováno v:
Nature Communications
Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-sized particles in liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2305a64feeacf68dfc99524177bfbc53
https://pubmed.ncbi.nlm.nih.gov/28198362
https://pubmed.ncbi.nlm.nih.gov/28198362
Autor:
Filippo De Simone, Jerome Waser
Publikováno v:
Synlett. 2011:589-593
The regioselective and diastereoselective cyclization of acyliminium intermediates generated from aminocyclopropanes on unprotected indoles is presented. The recent results obtained in our group are compared with previous intermolecular reactions wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dca50296ce33fc44f8573b7e90fb1ce
https://doi.org/10.1055/s-0030-1259553
https://doi.org/10.1055/s-0030-1259553
Publikováno v:
Angewandte Chemie International Edition. 49:5767-5770
Mild Control: Selective cyclization of aminocyclopropanes on the N1 or C3 positions of indole was achieved by tuning the catalyst and solvent. The new strategy was applied to the formal synthesis of aspidospermidine and the total synthesis of goniomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c701ba713b52684cce9297977d6d20b
https://doi.org/10.1002/anie.201001853
https://doi.org/10.1002/anie.201001853
Autor:
Jerome Waser, Stefano Nicolai, Filippo De Simone, Davinia Fernandez Gonzalez, Jonathan P. Brand
Publikováno v:
ChemInform. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732db8107422728112c7ac426d304b7f
https://doi.org/10.1002/chin.201209264
https://doi.org/10.1002/chin.201209264
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 17(51)
The Nazarov cyclization of divinyl ketones gives access to cyclopentenones. Replacing one of the vinyl groups by a cyclopropane leads to a formal homo-Nazarov process for the synthesis of cyclohexenones. In contrast to the Nazarov reaction, the cycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366193dd2f9b26214873468e4c480d2a
https://pubmed.ncbi.nlm.nih.gov/22113928
https://pubmed.ncbi.nlm.nih.gov/22113928
Autor:
Jerome Waser, Filippo De Simone
Publikováno v:
ChemInform. 42
The regioselective and diastereoselective cyclization of acyliminium intermediates generated from aminocyclopropanes on unprotected indoles is presented. The recent results obtained in our group are compared with previous intermolecular reactions wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c27e1a9a47e8bd363fc1aa427e108d
https://doi.org/10.1002/chin.201127254
https://doi.org/10.1002/chin.201127254