Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Filippo Beleggia"'
Autor:
Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt, Silvia von Karstedt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The high degree of subtype plasticity in small cell lung cancer (SCLC) poses a therapeutic challenge. Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vul
Externí odkaz:
https://doaj.org/article/72d102a3804747f8993f740dde35ff92
Autor:
Gero Knittel, Tim Rehkämper, Darya Korovkina, Paul Liedgens, Christian Fritz, Alessandro Torgovnick, Yussor Al-Baldawi, Mona Al-Maarri, Yupeng Cun, Oleg Fedorchenko, Arina Riabinska, Filippo Beleggia, Phuong-Hien Nguyen, F. Thomas Wunderlich, Monika Ortmann, Manuel Montesinos-Rongen, Eugen Tausch, Stephan Stilgenbauer, Lukas P. Frenzel, Marco Herling, Carmen Herling, Jasmin Bahlo, Michael Hallek, Martin Peifer, Reinhard Buettner, Thorsten Persigehl, H. Christian Reinhardt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is s
Externí odkaz:
https://doaj.org/article/93c8b6674f2b4c01a38589c9951b35af
Autor:
Alessandro Torgovnick, Jan Michel Heger, Vasiliki Liaki, Jörg Isensee, Anna Schmitt, Gero Knittel, Arina Riabinska, Filippo Beleggia, Lucie Laurien, Uschi Leeser, Christian Jüngst, Florian Siedek, Wenzel Vogel, Niklas Klümper, Hendrik Nolte, Maike Wittersheim, Lars Tharun, Roberta Castiglione, Marcus Krüger, Astrid Schauss, Sven Perner, Manolis Pasparakis, Reinhard Büttner, Thorsten Persigehl, Tim Hucho, Grit Sophie Herter-Sprie, Björn Schumacher, Hans Christian Reinhardt
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1027-1039.e6 (2018)
Summary: Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to gen
Externí odkaz:
https://doaj.org/article/662c648938254acfa54677dfa23bd2fb
Autor:
Julia Hatzold, Filippo Beleggia, Hannah Herzig, Janine Altmüller, Peter Nürnberg, Wilhelm Bloch, Bernd Wollnik, Matthias Hammerschmidt
Publikováno v:
eLife, Vol 5 (2016)
The molecular pathways underlying tumor suppression are incompletely understood. Here, we identify cooperative non-cell-autonomous functions of a single gene that together provide a novel mechanism of tumor suppression in basal keratinocytes of zebra
Externí odkaz:
https://doaj.org/article/b21f9b49732e47a08beeab8ec0776256
Autor:
Gero Knittel, Hans Christian Reinhardt, Ari M. Melnick, Ron D. Jachimowicz, Bastian von Tresckow, F. Thomas Wunderlich, Branko Zevnik, Bjoern Chapuy, Joachim R. Göthert, Sebastian Klein, Markus Chmielewski, Dinis Pedro Calado, Michael Hallek, Thorsten Persigehl, Monika Ortmann, Jörn Meinel, Philipp Lohneis, Reinhard Büttner, Alessandra Holzem, Filippo Beleggia, Lorenz Jonigkeit, Jacqueline Knüfer, Moritz Kochanek, Roman K. Thomas, Graziella Bosco, Nima Abedpour, Martin Peifer, Phuong-Hien Nguyen, Viktoria Kohlhas, Tobias Riet, Ilmars Kisis, Tim Lohmann, Pascal Nieper, Benedikt W. Pelzer, Julia Hansen, Ruth Flümann
Table S1 contains the p values of comparisons of the V gene usage in non-malignant GC B cells between the individual genotypes. These comparisons were done on the family, gene and allele level. V usage was compared for all BCR sequences as well as fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16522456824017cbee9d61e5a078d618
https://doi.org/10.1158/2643-3230.22546170.v1
https://doi.org/10.1158/2643-3230.22546170.v1
Autor:
Gero Knittel, Hans Christian Reinhardt, Ari M. Melnick, Ron D. Jachimowicz, Bastian von Tresckow, F. Thomas Wunderlich, Branko Zevnik, Bjoern Chapuy, Joachim R. Göthert, Sebastian Klein, Markus Chmielewski, Dinis Pedro Calado, Michael Hallek, Thorsten Persigehl, Monika Ortmann, Jörn Meinel, Philipp Lohneis, Reinhard Büttner, Alessandra Holzem, Filippo Beleggia, Lorenz Jonigkeit, Jacqueline Knüfer, Moritz Kochanek, Roman K. Thomas, Graziella Bosco, Nima Abedpour, Martin Peifer, Phuong-Hien Nguyen, Viktoria Kohlhas, Tobias Riet, Ilmars Kisis, Tim Lohmann, Pascal Nieper, Benedikt W. Pelzer, Julia Hansen, Ruth Flümann
This file contains the Supplementary Figures S1 to S12.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cef089d690f63351b9669b9955cf0e
https://doi.org/10.1158/2643-3230.22546173
https://doi.org/10.1158/2643-3230.22546173
Autor:
Gero Knittel, Hans Christian Reinhardt, Ari M. Melnick, Ron D. Jachimowicz, Bastian von Tresckow, F. Thomas Wunderlich, Branko Zevnik, Bjoern Chapuy, Joachim R. Göthert, Sebastian Klein, Markus Chmielewski, Dinis Pedro Calado, Michael Hallek, Thorsten Persigehl, Monika Ortmann, Jörn Meinel, Philipp Lohneis, Reinhard Büttner, Alessandra Holzem, Filippo Beleggia, Lorenz Jonigkeit, Jacqueline Knüfer, Moritz Kochanek, Roman K. Thomas, Graziella Bosco, Nima Abedpour, Martin Peifer, Phuong-Hien Nguyen, Viktoria Kohlhas, Tobias Riet, Ilmars Kisis, Tim Lohmann, Pascal Nieper, Benedikt W. Pelzer, Julia Hansen, Ruth Flümann
Genomic profiling revealed the identity of at least 5 subtypes of diffuse large B-cell lymphoma (DLBCL), including the MCD/C5 cluster characterized by aberrations in MYD88, BCL2, PRDM1, and/or SPIB. We generated mouse models harboring B cell–specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278e9a4312ef1b4ce85aa06afa865ce1
https://doi.org/10.1158/2643-3230.c.6551112.v1
https://doi.org/10.1158/2643-3230.c.6551112.v1
Autor:
Hans C. Reinhardt, Tim Hucho, Thorsten Persigehl, Florian Siedek, Rainer W. J. Kaiser, Anna Schmitt, Filippo Beleggia, André Toschka, Leonard A. Lobbes, Jörg Isensee, Joachim D. Steiner, Johanna Erber
The advent of molecularly targeted therapeutic agents has opened a new era in cancer therapy. However, many tumors rely on nondruggable cancer-driving lesions. In addition, long-lasting clinical benefits from single-agent therapies rarely occur, as m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6396e06eeff0ee65f06b6cda1afa5d9
https://doi.org/10.1158/0008-5472.c.6511272.v1
https://doi.org/10.1158/0008-5472.c.6511272.v1
Autor:
Hans C. Reinhardt, Tim Hucho, Thorsten Persigehl, Florian Siedek, Rainer W. J. Kaiser, Anna Schmitt, Filippo Beleggia, André Toschka, Leonard A. Lobbes, Jörg Isensee, Joachim D. Steiner, Johanna Erber
Table S5 contains data of the GSEA analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb3fd557a38b242c30ed65658b3f6db
https://doi.org/10.1158/0008-5472.22422567
https://doi.org/10.1158/0008-5472.22422567
Autor:
Hans C. Reinhardt, Tim Hucho, Thorsten Persigehl, Florian Siedek, Rainer W. J. Kaiser, Anna Schmitt, Filippo Beleggia, André Toschka, Leonard A. Lobbes, Jörg Isensee, Joachim D. Steiner, Johanna Erber
Figure S1 shows single agent dose-response curves of 18 compounds employed in the screen. Figure S2 shows synergy scores of 23 compound combinations. Figure S3 shows the apoptotic effects of single agent inhibitors and their combinations on a panel o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06490850f1cffd0a2d8d0966d8f1fb0
https://doi.org/10.1158/0008-5472.22422588.v1
https://doi.org/10.1158/0008-5472.22422588.v1