Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Filippo Basagni"'
Autor:
Filippo Basagni, Maria Luisa Di Paolo, Giorgio Cozza, Lisa Dalla Via, Francesca Fagiani, Cristina Lanni, Michela Rosini, Anna Minarini
Publikováno v:
Molecules, Vol 28, Iss 21, p 7424 (2023)
Oxidative stress and neuroinflammation play a pivotal role in triggering the neurodegenerative pathological cascades which characterize neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. In search for potential efficient t
Externí odkaz:
https://doaj.org/article/52fb8f16b20044489c72598e7b1fc8ea
Autor:
Giulia Nordio, Francesco Piazzola, Giorgio Cozza, Monica Rossetto, Manuela Cervelli, Anna Minarini, Filippo Basagni, Elisa Tassinari, Lisa Dalla Via, Andrea Milelli, Maria Luisa Di Paolo
Publikováno v:
Molecules, Vol 28, Iss 17, p 6329 (2023)
Monoamine oxidases (MAOs) are well-known pharmacological targets in neurological and neurodegenerative diseases. However, recent studies have revealed a new role for MAOs in certain types of cancer such as glioblastoma and prostate cancer, in which t
Externí odkaz:
https://doaj.org/article/c91776a6f04d46d0b17a0f15fcc4c8ee
Publikováno v:
Molecules, Vol 28, Iss 11, p 4518 (2023)
Over the past two decades, the strategy of conjugating polyamine tails with bioactive molecules such as anticancer and antimicrobial agents, as well as antioxidant and neuroprotective scaffolds, has been widely exploited to enhance their pharmacologi
Externí odkaz:
https://doaj.org/article/c02998d1d9d2428c9fe4d4deb2da1351
Autor:
Maria Luisa Di Paolo, Manuela Cervelli, Paolo Mariottini, Alessia Leonetti, Fabio Polticelli, Michela Rosini, Andrea Milelli, Filippo Basagni, Rina Venerando, Enzo Agostinelli, Anna Minarini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 740-752 (2019)
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) a
Externí odkaz:
https://doaj.org/article/1dbc6fd3202f4f33b7717030344a779d
Autor:
Ali Koskela, Federico Manai, Filippo Basagni, Mikko Liukkonen, Michela Rosini, Stefano Govoni, Massimo Dal Monte, Adrian Smedowski, Kai Kaarniranta, Marialaura Amadio
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1385 (2022)
Antioxidant systems play key roles in many elderly diseases, including age-related macular degeneration (AMD). Oxidative stress, autophagy impairment and inflammation are well-described in AMD, especially in retinal pigment epithelial (RPE) cells. Th
Externí odkaz:
https://doaj.org/article/46e1e026e781474b986447754fb1bd4d
Autor:
Francesca Fagiani, Michele Catanzaro, Erica Buoso, Filippo Basagni, Daniele Di Marino, Stefano Raniolo, Marialaura Amadio, Eric H. Frost, Emanuela Corsini, Marco Racchi, Tamas Fulop, Stefano Govoni, Michela Rosini, Cristina Lanni
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 anti-inflammatory activity has been related to the crosstalk with th
Externí odkaz:
https://doaj.org/article/4b7dc9e5773142e4a45a0d02ec68629f
Autor:
Michele Catanzaro, Cristina Lanni, Filippo Basagni, Michela Rosini, Stefano Govoni, Marialaura Amadio
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Age-related macular degeneration (AMD) is a common disease with a multifactorial aetiology, still lacking effective and curative therapies. Among the early events triggering AMD is the deterioration of the retinal pigment epithelium (RPE), whose fund
Externí odkaz:
https://doaj.org/article/f4488813646d4e78ba5b6109cf6efc9e
Autor:
Antonio Shegani, Steven Kealey, Federico Luzi, Filippo Basagni, Joana do Mar Machado, Sevban Doğan Ekici, Alessandra Ferocino, Antony D. Gee, Salvatore Bongarzone
Publikováno v:
Chemical Reviews. 123:105-229
The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346700006e39d4168fb9489e6c20d02f
https://doi.org/10.1021/acs.chemrev.2c00398
https://doi.org/10.1021/acs.chemrev.2c00398
Autor:
Maria Grazia Rossino, Rosario Amato, Marialaura Amadio, Michela Rosini, Filippo Basagni, Maurizio Cammalleri, Massimo Dal Monte, Giovanni Casini
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1296 (2021)
Oxidative stress (OS) plays a key role in retinal dysfunctions and acts as a major trigger of inflammatory and neurodegenerative processes in several retinal diseases. To prevent OS-induced retinal damage, approaches based on the use of natural compo
Externí odkaz:
https://doaj.org/article/fbaafcc3263c42c4bfe611bb5dcf9a28
Publikováno v:
Molecules, Vol 25, Iss 17, p 4005 (2020)
Memantine (3,5-dimethyladamantan-1-amine) is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist approved for treatment of moderate-to-severe Alzheimer’s disease (AD), a neurodegenerative condition characterized by a p
Externí odkaz:
https://doaj.org/article/081c72f01e924c4ab426857e696f7484