Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Filipe Cabreiro"'
Autor:
Clara L. Essmann, Daniel Martinez-Martinez, Rosina Pryor, Kit-Yi Leung, Kalaivani Bala Krishnan, Prudence Pokway Lui, Nicholas D. E. Greene, André E. X. Brown, Vijay M. Pawar, Mandayam A. Srinivasan, Filipe Cabreiro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The development of reliable measures of health in ageing organisms is a need in ageing research. Using atomic force microscopy, here, the authors assess whole body stiffness of worms and show that it reflects organismal fitness.
Externí odkaz:
https://doaj.org/article/497f6a1f580e4f1db58b61849bc60df7
Autor:
Ivana Bjedov, Helena M Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C Regan, Janne M Toivonen, Michael P Murphy, Janet Thornton, Kerri J Kinghorn, Thomas P Neufeld, Filipe Cabreiro, Linda Partridge
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009083 (2020)
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila and is sufficient on its
Externí odkaz:
https://doaj.org/article/c18379ac1b6a41b382dffb438dd7eff6
Autor:
Cassandra Coburn, Erik Allman, Parag Mahanti, Alexandre Benedetto, Filipe Cabreiro, Zachary Pincus, Filip Matthijssens, Caroline Araiz, Abraham Mandel, Manolis Vlachos, Sally-Anne Edwards, Grahame Fischer, Alexander Davidson, Rosina E Pryor, Ailsa Stevens, Frank J Slack, Nektarios Tavernarakis, Bart P Braeckman, Frank C Schroeder, Keith Nehrke, David Gems
Publikováno v:
PLoS Biology, Vol 11, Iss 7, p e1001613 (2013)
For cells the passage from life to death can involve a regulated, programmed transition. In contrast to cell death, the mechanisms of systemic collapse underlying organismal death remain poorly understood. Here we present evidence of a cascade of cel
Externí odkaz:
https://doaj.org/article/b5384d0af3b54c4ea29373242cae6123
Autor:
Alina Renz, Mirjam Hohner, Maximilian Breitenbach, Jonathan Josephs-Spaulding, Johanna Dürrwald, Lena Best, Raphaël Jami, Georgios Marinos, Filipe Cabreiro, Andreas Dräger, Michael Schindler, Christoph Kaleta
The SARS-CoV-2 pandemic has reemphasized the urgent need to develop broad-spectrum antiviral therapies. Wedeveloped a computational pipeline that uses scRNA-Seq data to reconstruct the metabolic state of cells and tissuesduring viral infection. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff68f9efce36cccbc933124625af073c
Autor:
Esther Meron, Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph A. Baur, Simon Bekker-Jensen, Maria Birkisdottir, Evelyne Bischof, Jens Bruening, Anne Brunet, Abigail Buchwalter, Filipe Cabreiro, Shiqing Cai, Brian H. Chen, Maria Ermolaeva, Collin Y. Ewald, Luigi Ferrucci, Maria Carolina Florian, Kristen Fortney, Adam Freund, Anastasia Georgievskaya, Vadim N. Gladyshev, David Glass, Tyler Golato, Vera Gorbunova, Jan Hoejimakers, Riekelt H. Houtkooper, Sibylle Jager, Frank Jaksch, Georges Janssens, Martin Borch Jensen, Matt Kaeberlein, Gerard Karsenty, Peter de Keizer, Brian Kennedy, James L. Kirkland, Michael Kjaer, Guido Kroemer, Kai-Fu Lee, Jean-Marc Lemaitre, David Liaskos, Valter D. Longo, Yu-Xuan Lu, Michael R. MacArthur, Andrea B. Maier, Christina Manakanatas, Sarah J. Mitchell, Alexey Moskalev, Laura Niedernhofer, Ivan Ozerov, Linda Partridge, Emmanuelle Passegué, Michael A. Petr, James Peyer, Dina Radenkovic, Thomas A. Rando, Suresh Rattan, Christian G. Riedel, Lenhard Rudolph, Ruixue Ai, Manuel Serrano, Björn Schumacher, David A. Sinclair, Ryan Smith, Yousin Suh, Pam Taub, Alexandre Trapp, Anne-Ulrike Trendelenburg, Dario Riccardo Valenzano, Kris Verburgh, Eric Verdin, Jan Vijg, Rudi G.J. Westendorp, Alessandra Zonari, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen
Publikováno v:
Aging, 14(2), 532-543. Impact Journals LLC
Aging, vol 14, iss 2
Aging, 14 (2)
Meron, E, Thaysen, M, Angeli, S, Antebi, A, Barzilai, N, Baur, J A, Bekker-Jensen, S, Birkisdottir, M, Bischof, E, Bruening, J, Brunet, A, Buchwalter, A, Cabreiro, F, Cai, S, Chen, B H, Ermolaeva, M, Ewald, C Y, Ferrucci, L, Florian, M C, Fortney, K, Freund, A, Georgievskaya, A, Gladyshev, V N, Glass, D, Golato, T, Gorbunova, V, Hoejimakers, J, Houtkooper, R H, Jager, S, Jaksch, F, Janssens, G, Jensen, M B, Kaeberlein, M, Karsenty, G, de Keizer, P, Kennedy, B, Kirkland, J L, Kjaer, M, Kroemer, G, Lee, K-F, Lemaitre, J-M, Liaskos, D, Longo, V D, Lu, Y-X, MacArthur, M R, Maier, A B, Manakanatas, C, Mitchell, S J, Moskalev, A, Niedernhofer, L, Ozerov, I, Partridge, L, Passegué, E, Petr, M A, Peyer, J, Radenkovic, D, Rando, T A, Rattan, S, Riedel, C G, Rudolph, L, Ai, R, Serrano, M, Schumacher, B, Sinclair, D A, Smith, R, Suh, Y, Taub, P, Trapp, A, Trendelenburg, A-U, Valenzano, D R, Verburgh, K, Verdin, E, Vijg, J, Westendorp, R G J, Zonari, A, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2022, ' Meeting Report : Aging Research and Drug Discovery ', Aging, vol. 14, no. 2, pp. 532-543 . https://doi.org/10.18632/aging.203859
Aging, 14(2), 532-543. US Administration on Aging
Dipòsit Digital de la UB
Universidad de Barcelona
Meron, E, Thaysen, M, Angeli, S, Antebi, A, Barzilai, N, Baur, J A, Bekker-Jensen, S, Birkisdottir, M, Bischof, E, Bruening, J, Brunet, A, Buchwalter, A, Cabreiro, F, Cai, S, Chen, B H, Ermolaeva, M, Ewald, C Y, Ferrucci, L, Florian, M C, Fortney, K, Freund, A, Georgievskaya, A, Gladyshev, V N, Glass, D, Golato, T, Gorbunova, V, Hoejimakers, J, Houtkooper, R H, Jager, S, Jaksch, F, Janssens, G, Jensen, M B, Kaeberlein, M, Karsenty, G, de Keizer, P, Kennedy, B, Kirkland, J L, Kjaer, M, Kroemer, G, Lee, K F, Lemaitre, J M, Liaskos, D, Longo, V D, Lu, Y X, MacArthur, M R, Maier, A B, Manakanatas, C, Mitchell, S J, Moskalev, A, Niedernhofer, L, Ozerov, I, Partridge, L, Passegué, E, Petr, M A, Peyer, J, Radenkovic, D, Rando, T A, Rattan, S, Riedel, C G, Rudolph, L, Ai, R, Serrano, M, Schumacher, B, Sinclair, D A, Smith, R, Suh, Y, Taub, P, Trapp, A, Trendelenburg, A U, Valenzano, D R, Verburgh, K, Verdin, E, Vijg, J, Westendorp, R G J, Zonari, A, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2022, ' Meeting Report : Aging Research and Drug Discovery ', Aging, vol. 14, no. 2, pp. 530-543 . https://doi.org/10.18632/aging.203859
Aging, vol 14, iss 2
Aging, 14 (2)
Meron, E, Thaysen, M, Angeli, S, Antebi, A, Barzilai, N, Baur, J A, Bekker-Jensen, S, Birkisdottir, M, Bischof, E, Bruening, J, Brunet, A, Buchwalter, A, Cabreiro, F, Cai, S, Chen, B H, Ermolaeva, M, Ewald, C Y, Ferrucci, L, Florian, M C, Fortney, K, Freund, A, Georgievskaya, A, Gladyshev, V N, Glass, D, Golato, T, Gorbunova, V, Hoejimakers, J, Houtkooper, R H, Jager, S, Jaksch, F, Janssens, G, Jensen, M B, Kaeberlein, M, Karsenty, G, de Keizer, P, Kennedy, B, Kirkland, J L, Kjaer, M, Kroemer, G, Lee, K-F, Lemaitre, J-M, Liaskos, D, Longo, V D, Lu, Y-X, MacArthur, M R, Maier, A B, Manakanatas, C, Mitchell, S J, Moskalev, A, Niedernhofer, L, Ozerov, I, Partridge, L, Passegué, E, Petr, M A, Peyer, J, Radenkovic, D, Rando, T A, Rattan, S, Riedel, C G, Rudolph, L, Ai, R, Serrano, M, Schumacher, B, Sinclair, D A, Smith, R, Suh, Y, Taub, P, Trapp, A, Trendelenburg, A-U, Valenzano, D R, Verburgh, K, Verdin, E, Vijg, J, Westendorp, R G J, Zonari, A, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2022, ' Meeting Report : Aging Research and Drug Discovery ', Aging, vol. 14, no. 2, pp. 532-543 . https://doi.org/10.18632/aging.203859
Aging, 14(2), 532-543. US Administration on Aging
Dipòsit Digital de la UB
Universidad de Barcelona
Meron, E, Thaysen, M, Angeli, S, Antebi, A, Barzilai, N, Baur, J A, Bekker-Jensen, S, Birkisdottir, M, Bischof, E, Bruening, J, Brunet, A, Buchwalter, A, Cabreiro, F, Cai, S, Chen, B H, Ermolaeva, M, Ewald, C Y, Ferrucci, L, Florian, M C, Fortney, K, Freund, A, Georgievskaya, A, Gladyshev, V N, Glass, D, Golato, T, Gorbunova, V, Hoejimakers, J, Houtkooper, R H, Jager, S, Jaksch, F, Janssens, G, Jensen, M B, Kaeberlein, M, Karsenty, G, de Keizer, P, Kennedy, B, Kirkland, J L, Kjaer, M, Kroemer, G, Lee, K F, Lemaitre, J M, Liaskos, D, Longo, V D, Lu, Y X, MacArthur, M R, Maier, A B, Manakanatas, C, Mitchell, S J, Moskalev, A, Niedernhofer, L, Ozerov, I, Partridge, L, Passegué, E, Petr, M A, Peyer, J, Radenkovic, D, Rando, T A, Rattan, S, Riedel, C G, Rudolph, L, Ai, R, Serrano, M, Schumacher, B, Sinclair, D A, Smith, R, Suh, Y, Taub, P, Trapp, A, Trendelenburg, A U, Valenzano, D R, Verburgh, K, Verdin, E, Vijg, J, Westendorp, R G J, Zonari, A, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2022, ' Meeting Report : Aging Research and Drug Discovery ', Aging, vol. 14, no. 2, pp. 530-543 . https://doi.org/10.18632/aging.203859
Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the industry and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca268f4a239fad37509fde42f194356b
https://pure.eur.nl/en/publications/17785adf-5acc-402b-8ef1-3bbeaa0050c7
https://pure.eur.nl/en/publications/17785adf-5acc-402b-8ef1-3bbeaa0050c7
Autor:
Filipe Cabreiro, Bianca Bana
Publikováno v:
Annual Review of Genetics. 53:239-261
Aging is a natural process of organismal decay that underpins the development of myriad diseases and disorders. Extensive efforts have been made to understand the biology of aging and its regulation, but most studies focus solely on the host organism
Autor:
Thomas Bock, Sonja Blasche, Manuel Banzhaf, Daniel C. Sévin, Kiran Raosaheb Patil, Filipe Cabreiro, Katharina Zirngibl, Martin Beck, Prasad Phapale, André Mateus, Leo Nesme, Martina Klünemann, Sergej Andrejev, Yongkyu Kim, Saravanan Devendran, Eleni Kafkia, Manjeet Kumar, Peer Bork, Lisa A. Maier, Timothy A. Scott, Eleonora Mastrorilli, Athanasios Typas, Carsten Schultz, Melanie Tramontano, Ana Rita Brochado, Mikhail M. Savitski, Felix Hövelmann, Dimitrios Konstantinidis, Marie-Therese Mackmull, Johanna Vappiani, Michael B. Zimmermann, Janosch Hennig, Vinita Periwal, Bernd Simon
Publikováno v:
Nature
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently1 and the main underlying mechanism proposed is the chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7945cab1a921806bff4628d6ea786d
https://hdl.handle.net/21.11116/0000-0009-246C-6
https://hdl.handle.net/21.11116/0000-0009-246C-6
Autor:
Linda Partridge, Jorge Iván Castillo-Quan, Jennifer C. Regan, Andrea Foley, Janne M. Toivonen, Daniela Wieser, Ivana Bjedov, Janet M. Thornton, Helena M. Cochemé, Povilas Norvaisas, Kerri J. Kinghorn, Michael P. Murphy, Celia Lujan, Filipe Cabreiro, Nathaniel S. Woodling, Thomas P. Neufeld
Publikováno v:
PLOS Genetics
PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009083 (2020)
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
PLoS Genet
PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009083 (2020)
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
PLoS Genet
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila and is sufficient on its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79f41cde8de708515e486eb71f77925
http://zaguan.unizar.es/record/97453
http://zaguan.unizar.es/record/97453
Autor:
Melissa R. Cruz, Danielle A. Garsin, Yi Liu, Filipe Cabreiro, Clara L. Essmann, Daniel Martinez-Martinez
Publikováno v:
G3: Genes|Genomes|Genetics
The nematode Caenorhabditis elegans is commonly used as a model organism in studies of the host immune response. The worm encodes twelve peroxidase-cyclooxygenase superfamily members, making it an attractive model in which to study the functions of h
Publikováno v:
Lab animal. 50(5)
Microbes are an integral part of life on this planet. Microbes and their hosts influence each other in an endless dance that shapes how the meta-organism interacts with its environment. Although great advances have been made in microbiome research ov