Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans

Autor: Clara L. Essmann, Daniel Martinez-Martinez, Rosina Pryor, Kit-Yi Leung, Kalaivani Bala Krishnan, Prudence Pokway Lui, Nicholas D. E. Greene, André E. X. Brown, Vijay M. Pawar, Mandayam A. Srinivasan, Filipe Cabreiro

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

The development of reliable measures of health in ageing organisms is a need in ageing research. Using atomic force microscopy, here, the authors assess whole body stiffness of worms and show that it reflects organismal fitness.

Externí odkaz: https://doaj.org/article/497f6a1f580e4f1db58b61849bc60df7

Metabolic Modeling Elucidates Phenformin and Atpenin A5 as Broad-Spectrum Antiviral Drugs

Autor: Alina Renz, Mirjam Hohner, Maximilian Breitenbach, Jonathan Josephs-Spaulding, Johanna Dürrwald, Lena Best, Raphaël Jami, Georgios Marinos, Filipe Cabreiro, Andreas Dräger, Michael Schindler, Christoph Kaleta

The SARS-CoV-2 pandemic has reemphasized the urgent need to develop broad-spectrum antiviral therapies. Wedeveloped a computational pipeline that uses scRNA-Seq data to reconstruct the metabolic state of cells and tissuesduring viral infection. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff68f9efce36cccbc933124625af073c

Meeting Report: Aging Research and Drug Discovery

Autor: Esther Meron, Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph A. Baur, Simon Bekker-Jensen, Maria Birkisdottir, Evelyne Bischof, Jens Bruening, Anne Brunet, Abigail Buchwalter, Filipe Cabreiro, Shiqing Cai, Brian H. Chen, Maria Ermolaeva, Collin Y. Ewald, Luigi Ferrucci, Maria Carolina Florian, Kristen Fortney, Adam Freund, Anastasia Georgievskaya, Vadim N. Gladyshev, David Glass, Tyler Golato, Vera Gorbunova, Jan Hoejimakers, Riekelt H. Houtkooper, Sibylle Jager, Frank Jaksch, Georges Janssens, Martin Borch Jensen, Matt Kaeberlein, Gerard Karsenty, Peter de Keizer, Brian Kennedy, James L. Kirkland, Michael Kjaer, Guido Kroemer, Kai-Fu Lee, Jean-Marc Lemaitre, David Liaskos, Valter D. Longo, Yu-Xuan Lu, Michael R. MacArthur, Andrea B. Maier, Christina Manakanatas, Sarah J. Mitchell, Alexey Moskalev, Laura Niedernhofer, Ivan Ozerov, Linda Partridge, Emmanuelle Passegué, Michael A. Petr, James Peyer, Dina Radenkovic, Thomas A. Rando, Suresh Rattan, Christian G. Riedel, Lenhard Rudolph, Ruixue Ai, Manuel Serrano, Björn Schumacher, David A. Sinclair, Ryan Smith, Yousin Suh, Pam Taub, Alexandre Trapp, Anne-Ulrike Trendelenburg, Dario Riccardo Valenzano, Kris Verburgh, Eric Verdin, Jan Vijg, Rudi G.J. Westendorp, Alessandra Zonari, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen

Publikováno v: Aging, 14(2), 532-543. Impact Journals LLC
Aging, vol 14, iss 2
Aging, 14 (2)
Meron, E, Thaysen, M, Angeli, S, Antebi, A, Barzilai, N, Baur, J A, Bekker-Jensen, S, Birkisdottir, M, Bischof, E, Bruening, J, Brunet, A, Buchwalter, A, Cabreiro, F, Cai, S, Chen, B H, Ermolaeva, M, Ewald, C Y, Ferrucci, L, Florian, M C, Fortney, K, Freund, A, Georgievskaya, A, Gladyshev, V N, Glass, D, Golato, T, Gorbunova, V, Hoejimakers, J, Houtkooper, R H, Jager, S, Jaksch, F, Janssens, G, Jensen, M B, Kaeberlein, M, Karsenty, G, de Keizer, P, Kennedy, B, Kirkland, J L, Kjaer, M, Kroemer, G, Lee, K-F, Lemaitre, J-M, Liaskos, D, Longo, V D, Lu, Y-X, MacArthur, M R, Maier, A B, Manakanatas, C, Mitchell, S J, Moskalev, A, Niedernhofer, L, Ozerov, I, Partridge, L, Passegué, E, Petr, M A, Peyer, J, Radenkovic, D, Rando, T A, Rattan, S, Riedel, C G, Rudolph, L, Ai, R, Serrano, M, Schumacher, B, Sinclair, D A, Smith, R, Suh, Y, Taub, P, Trapp, A, Trendelenburg, A-U, Valenzano, D R, Verburgh, K, Verdin, E, Vijg, J, Westendorp, R G J, Zonari, A, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2022, ' Meeting Report : Aging Research and Drug Discovery ', Aging, vol. 14, no. 2, pp. 532-543 . https://doi.org/10.18632/aging.203859
Aging, 14(2), 532-543. US Administration on Aging
Dipòsit Digital de la UB
Universidad de Barcelona
Meron, E, Thaysen, M, Angeli, S, Antebi, A, Barzilai, N, Baur, J A, Bekker-Jensen, S, Birkisdottir, M, Bischof, E, Bruening, J, Brunet, A, Buchwalter, A, Cabreiro, F, Cai, S, Chen, B H, Ermolaeva, M, Ewald, C Y, Ferrucci, L, Florian, M C, Fortney, K, Freund, A, Georgievskaya, A, Gladyshev, V N, Glass, D, Golato, T, Gorbunova, V, Hoejimakers, J, Houtkooper, R H, Jager, S, Jaksch, F, Janssens, G, Jensen, M B, Kaeberlein, M, Karsenty, G, de Keizer, P, Kennedy, B, Kirkland, J L, Kjaer, M, Kroemer, G, Lee, K F, Lemaitre, J M, Liaskos, D, Longo, V D, Lu, Y X, MacArthur, M R, Maier, A B, Manakanatas, C, Mitchell, S J, Moskalev, A, Niedernhofer, L, Ozerov, I, Partridge, L, Passegué, E, Petr, M A, Peyer, J, Radenkovic, D, Rando, T A, Rattan, S, Riedel, C G, Rudolph, L, Ai, R, Serrano, M, Schumacher, B, Sinclair, D A, Smith, R, Suh, Y, Taub, P, Trapp, A, Trendelenburg, A U, Valenzano, D R, Verburgh, K, Verdin, E, Vijg, J, Westendorp, R G J, Zonari, A, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2022, ' Meeting Report : Aging Research and Drug Discovery ', Aging, vol. 14, no. 2, pp. 530-543 . https://doi.org/10.18632/aging.203859

Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the industry and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca268f4a239fad37509fde42f194356b
https://pure.eur.nl/en/publications/17785adf-5acc-402b-8ef1-3bbeaa0050c7

The Microbiome and Aging

Autor: Filipe Cabreiro, Bianca Bana

Publikováno v: Annual Review of Genetics. 53:239-261

Aging is a natural process of organismal decay that underpins the development of myriad diseases and disorders. Extensive efforts have been made to understand the biology of aging and its regulation, but most studies focus solely on the host organism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9648f7424f3d0fc3b60e9707313d45bb
https://doi.org/10.1146/annurev-genet-112618-043650

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans.

Autor: Cassandra Coburn, Erik Allman, Parag Mahanti, Alexandre Benedetto, Filipe Cabreiro, Zachary Pincus, Filip Matthijssens, Caroline Araiz, Abraham Mandel, Manolis Vlachos, Sally-Anne Edwards, Grahame Fischer, Alexander Davidson, Rosina E Pryor, Ailsa Stevens, Frank J Slack, Nektarios Tavernarakis, Bart P Braeckman, Frank C Schroeder, Keith Nehrke, David Gems

Publikováno v: PLoS Biology, Vol 11, Iss 7, p e1001613 (2013)

For cells the passage from life to death can involve a regulated, programmed transition. In contrast to cell death, the mechanisms of systemic collapse underlying organismal death remain poorly understood. Here we present evidence of a cascade of cel

Externí odkaz: https://doaj.org/article/b5384d0af3b54c4ea29373242cae6123