VIH: Aspectos Neuropsiquiátricos da Infecção e da Terapêutica

Autor: Rute Alves, Ana Margarida Baptista, Adriana Moutinho, Filipa Moutinho, Joana Teixeira

Publikováno v: PsiLogos, Vol 11, Iss 1 (2013)

Desde o seu reconhecimento na década de 80, a infecção por VIH atingiu já 65 milhões de pessoas, em todo o mundo. A presença do vírus no SNC acontece na maioria dos doentes afectados, sendo cada vez mais identificadas perturbações n

Externí odkaz: https://doaj.org/article/0b58e7ca03b046de8ea0a0e2f798f97c

The silent impact: codon usage bias and protein evolution in bacteria

Autor: Ana Filipa Moutinho, Adam Eyre-Walker

Bias in synonymous codon usage has been reported across all kingdoms of life. Evidence across species suggests that codon usage bias is often driven by selective pressures, typically for translational efficiency. These selective pressures have been s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d829b3690d16cb4c10ae5753358ba80
https://doi.org/10.1101/2022.07.07.499116

Strong evidence for the adaptive walk model of gene evolution in Drosophila and Arabidopsis

Autor: Ana Filipa Moutinho, Adam Eyre-Walker, Julien Y. Dutheil

Publikováno v: PLoS Biology

Understanding the dynamics of species adaptation to their environments has long been a central focus of the study of evolution. Theories of adaptation propose that populations evolve by “walking” in a fitness landscape. This “adaptive walk” i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b187d1bb2e3b2707215f9bd6872748be
https://pubmed.ncbi.nlm.nih.gov/36099311

Variation of the adaptive substitution rate between species and within genomes

Autor: Julien Y. Dutheil, Ana Filipa Moutinho, Thomas Bataillon

Publikováno v: Moutinho, A F, Bataillon, T & Dutheil, J Y 2020, ' Variation of the adaptive substitution rate between species and within genomes ', Evolutionary Ecology, vol. 34, no. 3, pp. 315-338 . https://doi.org/10.1007/s10682-019-10026-z
Evolutionary Ecology

The importance of adaptive mutations in molecular evolution is extensively debated. Recent developments in population genomics allow inferring rates of adaptive mutations by fitting a distribution of fitness effects to the observed patterns of polymo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0986a681c290f499e972ba4033cc54a3
https://pure.au.dk/ws/files/221365764/Moutinho2020_Article_VariationOfTheAdaptiveSubstitu.pdf

Exposure to environmental radionuclides alters mitochondrial DNA maintenance in a wild rodent

Autor: Tapio Mappes, Anton Lavrinienko, Eugene Tukalenko, Anders Pape Møller, Jenni Kesäniemi, Timothy A. Mousseau, Phillip C. Watts, Ana Filipa Moutinho

Publikováno v: Evolutionary Ecology
Evolutionary Ecology, Springer Verlag, 2020, 34, pp.163-174. ⟨10.1007/s10682-019-10028-x⟩

Mitochondria are sensitive to oxidative stress, including that derived from ionizing radiation. To quantify the effects of exposure to environmental radionuclides on mitochondrial DNA (mtDNA) dynamics in wildlife, bank voles (Myodes glareolus) were c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3431cd0b231660f886433d2a10c924
http://urn.fi/urn:nbn:fi-fe2020052639132