Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Filipa Mota Quinteiro"'
Publikováno v:
Chemical Biology & Drug Design. 80:787-809
To deliver siRNA for therapeutic use, several hurdles must be addressed. Metabolic degradation must be blocked, and the RNAi cellular machinery is located in the cytoplasm, while double-stranded siRNA is large, highly charged and impermeable to cell
Autor:
David L. Selwood, Michela I. Simone, Roberta J. Worthington, Paul J. Gane, Adrian J. Hobbs, Snezana Djordevic, Filipa Mota Quinteiro, Anne-Sophie Rebstock
Publikováno v:
BMC Pharmacology
BackgroundEndothelium-derived C-type natriuretic peptide (CNP)possesses cytoprotective and anti-atherogenic functionsthat regulate vascular tone and smooth-muscle relaxa-tion and might be key in protecting against ischaemia-reperfusion injury [1]. Th