Further insights into the molecular complexity of the human sinus node - The role of 'novel' transcription factors and microRNAs

Autor: Vladislav S. Kuzmin, Weixuan Chen, Filip Virgil Perde, Mateusz K. Hołda, Halina Dobrzynski, Abimbola J. Aminu, Marcin Kuniewicz, Peter C. M. Molenaar, Andrew Atkinson, Robert T. Simms, Maria Petkova, Joseph Yanni, Zeyuan Yin, Alex D. Morris

Publikováno v: Aminu, A J, Petkova, M, Atkinson, A J, Yanni, J, Morris, A D, Simms, R T, Chen, W, Yin, Z, Kuniewicz, M, Holda, M K, Kuzmin, V S, Perde, F, Molenaar, P & Dobrzynski, H 2021, ' Further insights into the molecular complexity of the human sinus node-The role of 'novel' transcription factors and microRNAs ', Progress in biophysics and molecular biology, vol. 166, pp. 86-104 . https://doi.org/10.1016/j.pbiomolbio.2021.04.008

RESEARCH PURPOSE: The sinus node (SN) is the heart's primary pacemaker. Key ion channels (mainly the funny channel, HCN4) and Ca2+-handling proteins in the SN are responsible for its function. Transcription factors (TFs) regulate gene expression thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7700c0b2042feec85a0e70f3fae4ba89
https://doi.org/10.1016/j.pbiomolbio.2021.04.008

Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node

Autor: Luke Stuart, Delvac Oceandy, Yu Zhang, Connor Geragthy, Halina Dobrzynski, Vadim V. Fedorov, Joseph Yanni, Alicia D'Souza, Andrew Atkinson, Alexandra Ivanova, Filip Virgil Perde, K. B. Pustovit, Amy Feather, Maria Petkova, Ning Li, Peter C. M. Molenaar, Abimbola J. Aminu

Publikováno v: Petkova, M, Atkinson, A J, Yanni, J, Stuart, L, Aminu, A J, Perde, F, Molenaar, P, Fedorov, V V & Dobrzynski, H 2020, ' Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node ', Journal of the American Heart Association, vol. 9, no. 20, pp. e016590 . https://doi.org/10.1161/JAHA.120.016590
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distinctive action potential morphology with spontaneous diastolic depolarization because of a unique expression of ion channels and Ca 2+ ‐handling proteins.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fedbb97322ca1ae9ce471df7c5e9b9
https://www.research.manchester.ac.uk/portal/en/publications/identification-of-key-small-noncoding-micrornas-controlling-pacemaker-mechanisms-in-the-human-sinus-node(082a62a1-035b-4454-97c8-0659839874a9).html

Funny current and sudden cardiac death

Autor: Joseph Yanni Gerges, Dan Dermengiu, Filip Virgil Perde, Halina Dobrzynski

Publikováno v: Romanian Journal of Legal Medicine. 23:95-100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2891784ea2d7548270246d2bcc8160ee
https://doi.org/10.4323/rjlm.2015.95