Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Filip Vanhoutte"'
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 529 (2019)
The physical stability of amorphous solid dispersions (ASD) of active pharmaceutical ingredients (APIs) of high glass forming ability (GFA class III) is generally expected to be high among the scientific community. In this study, the ASD of ten-selec
Externí odkaz:
https://doaj.org/article/7647a8386d6148dca36e03959d640370
Autor:
Hendrik Eyssen, Filip Vanhoutte, Guy P. Mannaerts, P. P. Van Veldhoven, G Vanhove, G. Parmentier
Publikováno v:
Journal of Biological Chemistry. 266:24670-24675
A number of isoprenoids (e.g. pristanic acid and the side chains of fat soluble-vitamins) is degraded or shortened via beta oxidation. We synthesized 2-methyl-palmitate and 2-methyl[1-14C] palmitate as a model substrate for the study of the beta oxid
Autor:
Guy P. Mannaerts, Filip Vanhoutte, G Dacremont, P. P. Van Veldhoven, G Vanhove, Hendrik Eyssen, G. Parmentier
Publikováno v:
Journal of Biological Chemistry. 266:24676-24683
Isoprenoid (branched) fatty acids such as pristanic acid can be degraded via beta-oxidation in peroxisomes. We synthesized 2-methylpalmitoyl-CoA as a model substrate in order to study the first step of the peroxisomal beta-oxidation of branched fatty
Publikováno v:
Journal of Cardiovascular Electrophysiology. 2:288-298
Enantioselective Electrophysiologic Actions of Tocainide. The electrophysiologic effects of the R (−) and S(+) enantiomers of tocainide, a Class IB antiarrhythmic drug, were studied in the guinea pig papillary muscle, using the standard microelectr
Publikováno v:
British Journal of Pharmacology. 103:1275-1281
1 Direct myocardial effects of the S(-)- and R(+)-enantiomers of bupivacaine were compared in the guinea-pig isolated papillary muscle by recording transmembrane action potentials with the standard microelectrode technique. 2 In 5.4 mM K+, at a stimu
Autor:
Chris Vervaet, Francois Menard, Ann Debunne, Jean Paul Remon, Filip Kiekens, Ivo Van Assche, Lieven Baert, Filip Vanhoutte
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 22(2-3)
The volume reduction behaviour of powders has been quantified by means of the ‘in-die’ yield pressure (YP) using Heckel analysis. However, because different YPs are reported for the same material, the experimental conditions influencing this mate
Autor:
Paul P. Van Veldhoven, Guy P. Mannaerts, Filip Vanhoutte, Hendrik Eyssen, Shewen Huang, G. Parmentier
Publikováno v:
Archives of biochemistry and biophysics. 296(1)
3-Methyl-substituted fatty acids are first oxidatively decarboxylated (alpha-oxidation) before they are degraded further via beta-oxidation. We synthesized [1-14C]phytanic and 3-[1-14C]methylmargaric acids in order to study their alpha-oxidation in i
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 344(6)
Disopyramide, a Class Ia antiarrhythmic drug, is clinically used as a racemic mixture; R(-)disopyramide and S(+)disopyramide. The major metabolite in man is desisopropyldisopyramide: R(-)desisopropyldisopyramide and S(+)desisopropyldisopyramide. The