Výsledky vyhledávání - "Filip Kukulski"

Akademický článek

Purine-Metabolizing Ectoenzymes Control IL-8 Production in Human Colon HT-29 Cells

Autor: Fariborz Bahrami, Filip Kukulski, Joanna Lecka, Alain Tremblay, Julie Pelletier, Liliana Rockenbach, Jean Sévigny

Publikováno v: Mediators of Inflammation, Vol 2014 (2014)

Interleukin-8 (IL-8) plays key roles in both chronic inflammatory diseases and tumor modulation. We previously observed that IL-8 secretion and function can be modulated by nucleotide (P2) receptors. Here we investigated whether IL-8 release by intes

Externí odkaz: https://doaj.org/article/fdd9b8806b3a411986ba8557bf6fb0d2

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Nucleoside Triphosphate Diphosphohydrolase-1 Ectonucleotidase Is Required for Normal Vas Deferens Contraction and Male Fertility through Maintaining P2X1 Receptor Function

Autor: Mireia Martín-Satué, Julie Pelletier, Filip Kukulski, Catherine Vial, Gilles Kauffenstein, Cristina Ribas Fürstenau, Bertrand Toutain, Daniel Henrion, Michal J. Sereda, Elise G. Lavoie, Jérôme Frenette, Robert Sullivan, Jean Sévigny, Sébastien S. Dufresne

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2014, 289 (41), pp.28629-39. ⟨10.1074/jbc.M114.604082⟩
The Journal of biological chemistry
The Journal of biological chemistry, 2014, 289 (41), pp.28629-39. ⟨10.1074/jbc.M114.604082⟩
Dipòsit Digital de la UB
Universidad de Barcelona

International audience; In this work, we report that Entpd1(-/-) mice, deficient for the ectonucleotidase nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), produce smaller litters (27% reduction) compared with wild-type C57BL6 animals. This de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c83b61152faa082f3b7b53cf3f0977
https://doi.org/10.1074/jbc.m114.604082

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Emerging role of extracellular nucleotides and adenosine in multiple sclerosis

Autor: Marek Cieślak, Filip Kukulski, Michał Komoszyński

Publikováno v: Purinergic Signalling

Extracellular nucleotides and adenosine play important roles in inflammation. These signaling molecules interact with the cell-surface-located P2 and P1 receptors, respectively, that are widely distributed in the central nervous system and generally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d0d93fdab5f6956bb8b7f56ff5e73f
https://doi.org/10.1007/s11302-011-9250-y

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NTPDase1 governs P2X7‐dependent functions in murine macrophages

Autor: Jean Sévigny, Filip Kukulski, Sébastien A. Lévesque, Simon C. Robson, Keiichi Enjyoji

Publikováno v: European Journal of Immunology. 40:1473-1485

P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel within the multiprotein inflammasome complex. Until now, little is known about regulation of P2X7 effector functions in macrophages. In this study, we show that nucleoside triphosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e253179e34604907e3aacb768609692
https://doi.org/10.1002/eji.200939741

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Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro

Autor: Jean Sévigny, Alain Tremblay, Filip Kukulski, Michel Fausther, Fariborz Bahrami, Fethia Ben Yebdri

Publikováno v: Molecular Immunology. 47:991-999

Previous studies showed that P2 receptors are involved in neutrophil migration via stimulation of chemokine release and by facilitating chemoattractant gradient sensing. Here, we have investigated whether these receptors are involved in LPS-induced n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4be9909690bfd054e368cc7ff7ed3a6
https://doi.org/10.1016/j.molimm.2009.11.020

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The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production

Autor: Mireia Martín-Satué, Fethia Ben Yebdri, Fariborz Bahrami, Jean Sévigny, Sébastien A. Lévesque, Filip Kukulski

Publikováno v: Molecular Immunology. 47:833-839

In this work, we show that P2 nucleotide receptors control lipopolysaccharide (LPS)-induced neutrophil migration in the mouse air pouch model. Neutrophil infiltration in LPS-treated air pouches was reduced by the intravenous (iv) administration of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91988080bf32059e66c6dffc3c92eec0
https://doi.org/10.1016/j.molimm.2009.09.037

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Concomitant activation of P2Y2and P2Y6receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion

Autor: Filip Kukulski, Fethia Ben Yebdri, Jean Sévigny, Alain Tremblay

Publikováno v: European Journal of Immunology. 39:2885-2894

Extracellular nucleotides regulate a variety of cellular responses involved in inflammation via the activation of P2 receptors. Here, we show that nucleotides regulate TLR2-induced neutrophil migration both in vivo and in vitro. The nucleotide scaven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3b2a4e682abb11d50a05270ced7712
https://doi.org/10.1002/eji.200939347

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Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists

Autor: Joanna Lecka, Gilles Kauffenstein, Charlène Legendre, Sébastien A. Lévesque, Julie Pelletier, Filip Kukulski, Mercedes N. Munkonda, Jean Sévigny, Elise G. Lavoie

Publikováno v: Biochemical Pharmacology. 74:1524-1534

The plasma membrane bound nucleoside triphosphate diphosphohydrolase (NTPDase)-1, 2, 3 and 8 are major ectonucleotidases that modulate P2 receptor signaling by controlling nucleotides' concentrations at the cell surface. In this report, we systematic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d3d70223075802603c427a143b704e
https://doi.org/10.1016/j.bcp.2007.07.033

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Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8

Autor: Jonathan A. Dranoff, Sébastien A. Lévesque, Michel Fausther, Julie Pelletier, Joanna Lecka, Filip Kukulski, Jean Sévigny, Herbert Zimmermann

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 292:G785-G795

Extracellular nucleotides regulate critical liver functions via the activation of specific transmembrane receptors. The hepatic levels of extracellular nucleotides, and therefore the related downstream signaling cascades, are modulated by cell-surfac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b7f7f5a73eec846cf778a296275593
https://doi.org/10.1152/ajpgi.00293.2006

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Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo

Autor: Michel Warny, Philippe A. Tessier, Fethia Ben Yebdri, Filip Kukulski, Julie S. Lefebvre, Jean Sévigny

Publikováno v: Journal of Leukocyte Biology. 81:1269-1275

Extracellular nucleotides are emerging as important inflammatory mediators. Here, we demonstrate that these molecules mediate LPS-induced neutrophil migration in vitro and in vivo. Apyrase, a nucleotide scavenger, reduced the ability of LPS-stimulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a75e00b374c8abfde472dda78dcf95
https://doi.org/10.1189/jlb.1206758

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