Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Filip K. Swirski"'
Autor:
Seung-Hyun Jung, Byung-Hee Hwang, Sun Shin, Eun-Hye Park, Sin-Hee Park, Chan Woo Kim, Eunmin Kim, Eunho Choo, Ik Jun Choi, Filip K. Swirski, Kiyuk Chang, Yeun-Jun Chung
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cellular composition and function are not clearly defined in heart failure after myocardial infarction. Here, using single cell and spatial transcriptomics in a MI-HF mouse model, the authors show that macrophages expressing Trem2 are found within th
Externí odkaz:
https://doaj.org/article/10989508b2cc463d9482cfab724b0a4a
Autor:
Naresh Ganesh, Emiel P. C. van der Vorst, Jens Spiesshöfer, Shun He, Mathias Burgmaier, Hannes Findeisen, Michael Lehrke, Filip K. Swirski, Nikolaus Marx, Florian Kahles
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Despite scientific and clinical advances during the last 50 years cardiovascular disease continues to be the main cause of death worldwide. Especially patients with diabetes display a massive increased cardiovascular risk compared to patients without
Externí odkaz:
https://doaj.org/article/2eb45829082e4aa7bcdfadc6b7c84be5
Autor:
Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy, Elisabeth Naschberger, Malgorzata J. Podolska, Dina Kouhestani, Paul David, Torsten Birkholz, Ixchel Castellanos, Denis Trufa, Horia Sirbu, Marcel Vetter, Andreas E. Kremer, Kai Hildner, Andreas Hecker, Fabian Edinger, Matthias Tenbusch, Petra Mühl-Zürbes, Alexander Steinkasserer, Enrico Richter, Hendrik Streeck, Marc M. Berger, Thorsten Brenner, Markus A. Weigand, Filip K. Swirski, Georg Schett, Robert Grützmann, Georg F. Weber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Here, the authors identify interleukin-3 as a predictive marker for severity and outcome of SARS-CoV-2 infection in a multi-center, prospective study and find that patients with severe COVID-19 have reduced circulating plasmacytoid dendritic cell lev
Externí odkaz:
https://doaj.org/article/da75b62b7c584d48a9ba0f701d8cd0cf
Autor:
Colin Valet, Mélia Magnen, Longhui Qiu, Simon J. Cleary, Kristin M. Wang, Serena Ranucci, Elodie Grockowiak, Rafik Boudra, Catharina Conrad, Yurim Seo, Daniel R. Calabrese, John R. Greenland, Andrew D. Leavitt, Emmanuelle Passegué, Simón Méndez-Ferrer, Filip K. Swirski, Mark R. Looney
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Platelets have a wide range of functions including critical roles in hemostasis, thrombosis, and immunity. We hypothesized that during acute inflammation, such as in life-threatening sepsis, there are fundamental changes in the sites of platelet prod
Externí odkaz:
https://doaj.org/article/c6be936c86a64996bba945d179a280f3
Autor:
Martina Gast, Vanasa Nageswaran, Andreas W. Kuss, Ana Tzvetkova, Xiaomin Wang, Liliana H. Mochmann, Pegah Ramezani Rad, Stefan Weiss, Stefan Simm, Tanja Zeller, Henry Voelzke, Wolfgang Hoffmann, Uwe Völker, Stefan B. Felix, Marcus Dörr, Antje Beling, Carsten Skurk, David-Manuel Leistner, Bernhard H. Rauch, Tetsuro Hirose, Bettina Heidecker, Karin Klingel, Shinichi Nakagawa, Wolfram C. Poller, Filip K. Swirski, Arash Haghikia, Wolfgang Poller
Publikováno v:
Cells, Vol 11, Iss 24, p 3970 (2022)
The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas functions ha
Externí odkaz:
https://doaj.org/article/ec8ff563749948efa86a683c898e23a4
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
Autor:
Manfred Nairz, David Haschka, Stefanie Dichtl, Thomas Sonnweber, Andrea Schroll, Malte Aßhoff, John E. Mindur, Patrizia L. Moser, Dominik Wolf, Filip K. Swirski, Igor Theurl, Anthony Cerami, Michael Brines, Günter Weiss
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular responses to erythropoietin (EPO) in different tissues. EPOR homodimers signal to promote the maturation of erythroid progenitor cells. In other cell types, includ
Externí odkaz:
https://doaj.org/article/3d221a86842e477ebdfddad36073f220
Autor:
Edmund J. Keliher, Yu-Xiang Ye, Gregory R. Wojtkiewicz, Aaron D. Aguirre, Benoit Tricot, Max L. Senders, Hannah Groenen, Francois Fay, Carlos Perez-Medina, Claudia Calcagno, Giuseppe Carlucci, Thomas Reiner, Yuan Sun, Gabriel Courties, Yoshiko Iwamoto, Hye-Yeong Kim, Cuihua Wang, John W. Chen, Filip K. Swirski, Hsiao-Ying Wey, Jacob Hooker, Zahi A. Fayad, Willem J. M. Mulder, Ralph Weissleder, Matthias Nahrendorf
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that
Externí odkaz:
https://doaj.org/article/a325edd59ddf4dab8474aa0b334a7eea
Autor:
Eric A. Shikatani, Rickvinder Besla, Sherine Ensan, Aditi Upadhye, Nadiya Khyzha, Angela Li, Takuo Emoto, Felix Chiu, Norbert Degousee, Joshua M. Moreau, Heather M. Perry, Danya Thayaparan, Henry S. Cheng, Shaun Pacheco, David Smyth, Hossein Noyan, Caleb C.J. Zavitz, Carla M.T. Bauer, Ingo Hilgendorf, Peter Libby, Filip K. Swirski, Jennifer L. Gommerman, Jason E. Fish, Martin R. Stampfli, Myron I. Cybulsky, Barry B. Rubin, Christopher J. Paige, Timothy P. Bender, Coleen A. McNamara, Mansoor Husain, Clinton S. Robbins
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2304-2312.e6 (2019)
Summary: Mechanisms that govern transcriptional regulation of inflammation in atherosclerosis remain largely unknown. Here, we identify the nuclear transcription factor c-Myb as an important mediator of atherosclerotic disease in mice. Atherosclerosi
Externí odkaz:
https://doaj.org/article/739dd39d1f244a6f8144a50e8b09c4c0
Autor:
Muhammad Ali, MD, Benjamin Pulli, MD, Gabriel Courties, PhD, Benoit Tricot, MSc, Matthew Sebas, BSc, Yoshiko Iwamoto, BSc, Ingo Hilgendorf, MD, Stefan Schob, MD, Anping Dong, MD, PhD, Wei Zheng, MD, Athanasia Skoura, PhD, Amit Kalgukar, PhD, Christian Cortes, MSc, Roger Ruggeri, PhD, Filip K. Swirski, PhD, Matthias Nahrendorf, MD, PhD, Leonard Buckbinder, PhD, John W. Chen, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 633-643 (2016)
PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 days decreased the number of inflammatory cells and attenuated left ven
Externí odkaz:
https://doaj.org/article/5d384185ad4c40cb8317d9fa9493cf98
Autor:
Binod Aryal, Noemi Rotllan, Elisa Araldi, Cristina M. Ramírez, Shun He, Benjamin G. Chousterman, Ashley M. Fenn, Amarylis Wanschel, Julio Madrigal-Matute, Nikhil Warrier, Jose L. Martín-Ventura, Filip K. Swirski, Yajaira Suárez, Carlos Fernández-Hernando
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Angiopoietin-like 4 protein (ANGPTL4) is a regulator of lipoprotein metabolism whose role in atherosclerosis has been controversial. Here the authors show that ANGPTL4 deficiency in haematopoietic cells increases atherogenesis by promoting myeloid pr
Externí odkaz:
https://doaj.org/article/40a361abcb9741eda09eb9b03b905155