Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Filip Golebiowski"'
Autor:
Patricia Domingues, Filip Golebiowski, Michael H. Tatham, Antonio M. Lopes, Aislynn Taggart, Ronald T. Hay, Benjamin G. Hale
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1467-1480 (2015)
Dynamic nuclear SUMO modifications play essential roles in orchestrating cellular responses to proteotoxic stress, DNA damage, and DNA virus infection. Here, we describe a non-canonical host SUMOylation response to the nuclear-replicating RNA pathoge
Externí odkaz:
https://doaj.org/article/ec9d436d39d24296bf8a741707b73eac
Autor:
Filip Golebiowski, Patricia Domingues, Benjamin G. Hale, Corinna Patzina, Ronald T. Hay, Nora Schmidt, Michael H. Tatham
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Primary host defenses against viruses involve specific cellular recognition of non-self nucleic acids as pathogen-associated molecular patterns (PAMPs) that trigger induction of cytokine-mediated antiviral responses. Thus, ability to dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cacf35ec281125640a3866675354e1
https://doi.org/10.1073/pnas.1907031116
https://doi.org/10.1073/pnas.1907031116
Publikováno v:
Nature Protocols. 5:873-882
The post-translational modification of proteins with ubiquitin and ubiquitin-like proteins (Ubl) is vital to many cellular functions, and thus the identification of Ubl targets is key to understanding their function. In most cases, only a small propo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c3211cc7b6ff367c4a9ce1bd60e812
https://doi.org/10.1038/nprot.2010.40
https://doi.org/10.1038/nprot.2010.40
Publikováno v:
Experimental Cell Research. 312:3252-3259
The molecular mechanisms of nickel-induced malignant cell transformation include effects altering the structure and covalent modifications of core histones. Previously, we found that exposure of cells to Ni(II) resulted in truncation of histones H2A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b031dac8af62887ff0055fafd7dd886
https://doi.org/10.1016/j.yexcr.2006.06.025
https://doi.org/10.1016/j.yexcr.2006.06.025
Publikováno v:
Chemical Research in Toxicology. 18:1934-1942
Molecular mechanisms of nickel-induced carcinogenesis include interactions of Ni(II) cations with histones. Previously, we demonstrated in vitro and in cells that Ni(II) cleaved off the -SHHKAKGK C-terminal motif of histone H2A. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40da7b00e5c85f9d96d7887751824053
https://doi.org/10.1021/tx050122a
https://doi.org/10.1021/tx050122a
Autor:
Alexandra Andrieux, Filip Golebiowski, Sabrina Fritah, Philippe J. Sansonetti, Ronald T. Hay, Joëlle Mounier, Nouara Lhocine, Anne Dejean, Grégory Jouvion
Publikováno v:
EMBO Reports
EMBO Reports, EMBO Press, 2014, 15 (9), pp.965-972. ⟨10.15252/embr.201338386⟩
EMBO Reports, 2014, 15 (9), pp.965-972. ⟨10.15252/embr.201338386⟩
Europe PubMed Central
EMBO reports
EMBO Reports, EMBO Press, 2014, 15 (9), pp.965-972. ⟨10.15252/embr.201338386⟩
EMBO Reports, 2014, 15 (9), pp.965-972. ⟨10.15252/embr.201338386⟩
Europe PubMed Central
EMBO reports
International audience; Shigella flexneri, the etiological agent of bacillary dysentery, invades the human colonic epithelium and causes its massive inflammatory destruction. Little is known about the post-translational modifications implicated in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acb2d182c5199abd3b4f54f514b7158
https://hal-pasteur.archives-ouvertes.fr/pasteur-03235051
https://hal-pasteur.archives-ouvertes.fr/pasteur-03235051
Publikováno v:
Molecular and Cellular Biochemistry. 226:49-55
The FHIT (fragile histidine triad) gene located at chromosome 3p14.2 has been proposed as a candidate tumor suppressor gene in human cancers. Fhit protein with the diadenosine 5',5'”-P1,P3-triphosphate (Ap3A) hydrolase activity is the protein produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b26f8bd489263962cdcc4c124936d911
https://doi.org/10.1023/a:1012729601270
https://doi.org/10.1023/a:1012729601270
Publikováno v:
Protein Expression and Purification. 18:320-326
The fragile histidine triad (Fhit) protein is a homodimeric protein with diadenosine 5',5"'-P(1),P(3)-triphosphate (Ap(3)A) asymmetrical hydrolase activity. We have cloned the human cDNA Fhit in the pPROEX-1 vector and expressed with high yield in Es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942c65750a5d4ad60a8f91100ffba751
https://doi.org/10.1006/prep.1999.1199
https://doi.org/10.1006/prep.1999.1199
Publikováno v:
Genesdevelopment. 26(11)
Here we demonstrate that RNF4, a highly conserved small ubiquitin-like modifier (SUMO)-targeted ubiquitin E3 ligase, plays a critical role in the response of mammalian cells to DNA damage. Human cells in which RNF4 expression was ablated by siRNA or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9b40761d77a99a9db450cf58464e0a
https://pubmed.ncbi.nlm.nih.gov/22661230
https://pubmed.ncbi.nlm.nih.gov/22661230
Publikováno v:
Molecular and cellular biochemistry. 279(1-2)
Nickel, a well-established human carcinogen, was shown to decrease acetylation of histones H4 and H3 in cultured cells. Such a decrease is expected to suppress gene expression. However, nickel is known to not only suppress but also enhance the expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af2412ea0533c9d7d582bf9ceb45c38
https://pubmed.ncbi.nlm.nih.gov/16283522
https://pubmed.ncbi.nlm.nih.gov/16283522