Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Filip A. Konopacki"'
Autor:
Filip A. Konopacki, Hovy Ho-Wai Wong, Asha Dwivedy, Anaïs Bellon, Michael D. Blower, Christine E. Holt
Publikováno v:
Open Biology, Vol 6, Iss 4 (2016)
Endocytosis and local protein synthesis (LPS) act coordinately to mediate the chemotropic responses of axons, but the link between these two processes is poorly understood. The endosomal sorting complex required for transport (ESCRT) is a key regulat
Externí odkaz:
https://doaj.org/article/b840736eec2a474caf211487ad2bb95c
Publikováno v:
Communicative & Integrative Biology
Kainate receptors (KARs) are tetrameric glutamate-gated ion channels composed of combinations of the subunits GluK1-5. Depending on their precise localization and subunit composition, KARs can regulate neurotransmitter release, synaptic function and
Autor:
Daniel L. Rocca, Philip Rubin, Sophie E.L. Chamberlain, Sriharsha Kantamneni, Kevin A. Wilkinson, Filip A. Konopacki, Jeremy M. Henley, Nadia Jaafari, Jack R. Mellor
Publikováno v:
Proceedings of the National Academy of Sciences
The surface expression and regulated endocytosis of kainate (KA) receptors (KARs) plays a critical role in neuronal function. PKC can modulate KAR trafficking, but the sites of action and molecular consequences have not been fully characterized. Smal
Autor:
Filip A. Konopacki, Nadia Jaafari, Daniel L. Rocca, Andrew J Doherty, Inmaculada M. González-González, Jeremy M. Henley, Kevin A. Wilkinson
Publikováno v:
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1:31-44
Kainate receptors (KARs) are ligand-gated ion channels that can regulate neuronal network activity and are involved in processes ranging from neuronal development and differentiation to neurodegeneration and neuronal cell death. They are tetrameric a
Autor:
Grzegorz M. Wilczynski, Maciej Gawlak, Adam Gorlewicz, T. Górkiewicz, Filip A. Konopacki, Leszek Kaczmarek
Publikováno v:
Neuroscience. 158:167-176
Synaptic plasticity involves remodeling of extracellular matrix. This is mediated, in part, by enzymes of the matrix metalloproteinase (MMP) family, in particular by gelatinase MMP-9. Accordingly, there is a need of developing methods to visualize ge
Autor:
Filip A. Konopacki, Beata Bielinska, Piotr Michaluk, Leszek Kaczmarek, Renata Amborska, Marcin Rylski, Grzegorz M. Wilczynski, Katarzyna Zybura
Publikováno v:
Molecular and Cellular Neuroscience
Molecular and Cellular Neuroscience; Vol 40
Molecular and Cellular Neuroscience; Vol 40
Matrix Metalloproteinase-9 (MMP-9) is an extracellularly operating enzyme involved in the synaptic plasticity, hippocampal-dependent long term memory and neurodegeneration. Previous studies have shown its upregulation following seizure-evoking stimul
Autor:
Witold Konopka, Evgeni V. Nikolaev, Barbara Mioduszewska, Zofia M. Lasiecka, Marcin Wawrzyniak, Filip A. Konopacki, Grzegorz M. Wilczynski, Dorota Owczarek, Adam Gorlewicz, Kamila Duniec, Piotr Michaluk, Leszek Kaczmarek, Ole Petter Ottersen, Pawel Okulski, Werner Zuschratter, Dariusz C. Górecki, Ewa Wilczek, Monika Malinowska, Agnieszka Walczak, Lukasz Kolodziej
Publikováno v:
The Journal of Cell Biology
Temporal lobe epilepsy (TLE) is a devastating disease in which aberrant synaptic plasticity plays a major role. We identify matrix metalloproteinase (MMP) 9 as a novel synaptic enzyme and a key pathogenic factor in two animal models of TLE: kainate-e
Autor:
Ewa Wilczek, Filip A. Konopacki, D. Detka, Leszek Kaczmarek, Renata Amborska, Marcin Rylski, Grzegorz M. Wilczynski
Publikováno v:
Neuroscience. 150:31-39
The phenomenon of dendritic transport and local translation of mRNA is considered to be one of the most fundamental mechanisms underlying long-term synaptic plasticity. Matrix metalloproteinase 9 (gelatinase B) (MMP-9) is a matrix metalloproteinase i
Autor:
Thérèse M. Jay, Grzegorz M. Wilczynski, Kamila Duniec, Filip A. Konopacki, Leszek Kaczmarek, Jacek Jaworski, Amelia Sánchez-Capelo, Jacques Mallet, Pawel Okulski, Joanna Dzwonek
Publikováno v:
Biological Psychiatry
Biological Psychiatry, 2007, 62 (4), pp.359-62. ⟨10.1016/j.biopsych.2006.09.012⟩
Biological Psychiatry, 2007, 62 (4), pp.359-62. ⟨10.1016/j.biopsych.2006.09.012⟩
Background Understanding of the molecular mechanisms of prefrontal cortex (PFC) plasticity is important for developing new treatment strategies for mental disorders such as depression and schizophrenia. Long-term potentiation (LTP) is a valid model f
Autor:
Grzegorz M. Wilczynski, Maria A. Ciemerych, Jacek Jaworski, Robert K. Filipkowski, Marcin Rylski, Anna Kowalczyk, Leszek Kaczmarek, Filip A. Konopacki, Piotr Sicinski
Publikováno v:
The Journal of Cell Biology
Adult neurogenesis (i.e., proliferation and differentiation of neuronal precursors in the adult brain) is responsible for adding new neurons in the dentate gyrus of the hippocampus and in the olfactory bulb. We describe herein that adult mice mutated