Zobrazeno 1 - 10
of 369
pro vyhledávání: '"Filip, Van Petegem"'
Autor:
Lianyun Lin, Changshi Wang, Wenlan Wang, Heng Jiang, Takashi Murayama, Takuya Kobayashi, Hadiatullah Hadiatullah, Yu Seby Chen, Shunfan Wu, Yiwen Wang, Henryk Korza, Yucheng Gu, Yan Zhang, Jiamu Du, Filip Van Petegem, Zhiguang Yuchi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The resistance of pests to common insecticides is a global issue that threatens food production worldwide. Diamide insecticides target insect ryanodine receptors (RyRs), causing uncontrolled calcium release from the sarcoplasmic and endoplas
Externí odkaz:
https://doaj.org/article/b5c8c7a447cf4ca59bbdb6683e1818bd
Autor:
Yu Seby Chen, Maricela Garcia-Castañeda, Maria Charalambous, Daniela Rossi, Vincenzo Sorrentino, Filip Van Petegem
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Ryanodine Receptor isoform 3 (RyR3) is a large ion channel found in the endoplasmic reticulum membrane of many different cell types. Within the hippocampal region of the brain, it is found in dendritic spines and regulates synaptic plasticit
Externí odkaz:
https://doaj.org/article/99a0a0c3b3b549beb8302f26252aaaaa
Autor:
Slade A. Loutet, Sylvia Cheung, Sarah Zaytsoff, Charles Hofacre, Matthew K. Jones, Filip Van Petegem, Hamlet Abnousi
Publikováno v:
Poultry Science, Vol 103, Iss 4, Pp 103578- (2024)
ABSTRACT: Necrotic enteritis is a devastating disease to poultry caused by the bacterium Clostridium perfringens. As a novel approach to combating poultry necrotic enteritis, we identified and characterized several hundred single domain antibody frag
Externí odkaz:
https://doaj.org/article/a023282a5da74fd6b6be85105500bebc
Autor:
Katrien Willegems, Jodene Eldstrom, Efthimios Kyriakis, Fariba Ataei, Harutyun Sahakyan, Ying Dou, Sophia Russo, Filip Van Petegem, David Fedida
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
KCNQ1 channels are active in heart, brain and gut. Functional loss causes epilepsy and sudden arrhythmic death. Here, authors describe a key activator drug binding site, explaining isoform and drug selectivity, and point the way for new drug design.
Externí odkaz:
https://doaj.org/article/36808af22e5f44a7951153674f707712
Autor:
James ZJ Kwan, Thomas F Nguyen, Anuli C Uzozie, Marek A Budzynski, Jieying Cui, Joseph MC Lee, Filip Van Petegem, Philipp F Lange, Sheila S Teves
Publikováno v:
eLife, Vol 12 (2023)
Transcription by RNA Polymerase II (Pol II) is initiated by the hierarchical assembly of the pre-initiation complex onto promoter DNA. Decades of research have shown that the TATA-box binding protein (TBP) is essential for Pol II loading and initiati
Externí odkaz:
https://doaj.org/article/f3dbb978e91b4b0dbade89a695ea59df
Autor:
Jessica Fernandes Scortecci, Laurie L. Molday, Susan B. Curtis, Fabian A. Garces, Pankaj Panwar, Filip Van Petegem, Robert S. Molday
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
ABCA4 is an ATP-binding cassette (ABC) transporter that flips N-retinylidenephosphatidylethanolamine (N-Ret-PE) to the cytoplasmic leaflet of photoreceptor membranes. ABCA4 mutations are associated with loss of vision. Here, structures of ABCA4 with
Externí odkaz:
https://doaj.org/article/c7f6dce4615b4c3fa5bb094bc2251eac
Autor:
Yanina-Yasmin Pesch, Vivien Dang, Michael John Fairchild, Fayeza Islam, Darius Camp, Priya Kaur, Christopher M Smendziuk, Anat Messenberg, Rosalyn Carr, Ciaran R McFarlane, Pierre-Yves Musso, Filip Van Petegem, Guy Tanentzapf
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010417 (2022)
Gametogenesis requires coordinated signaling between germ cells and somatic cells. We previously showed that Gap junction (GJ)-mediated soma-germline communication is essential for fly spermatogenesis. Specifically, the GJ protein Innexin4/Zero popul
Externí odkaz:
https://doaj.org/article/bcbdc7796db147f28edda2e750e27d80
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molec
Externí odkaz:
https://doaj.org/article/5b8b8e463ac84da9b0bd3809f5a34d32
Autor:
Juan Qin, Jingfeng Zhang, Lianyun Lin, Omid Haji-Ghassemi, Zhi Lin, Kenneth J Woycechowsky, Filip Van Petegem, Yan Zhang, Zhiguang Yuchi
Publikováno v:
eLife, Vol 11 (2022)
Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial. PLN interacts with sarco/endoplasmic reticulum Ca2+-ATPase
Externí odkaz:
https://doaj.org/article/7586687f069648989c8b379c95762a39
Autor:
Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, Omid Haji-Ghassemi, Romane Idoux, Anna Liashenko, Ivana A. Souza, Yuriy Rzhepetskyy, Lubica Lacinova, Filip Van Petegem, Gerald W. Zamponi, Roger Pamphlett, Norbert Weiss
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of cortical, brain stem and spinal motor neurons that leads to muscle weakness and death. A previous study implicated CACNA1H encoding
Externí odkaz:
https://doaj.org/article/aa77ecf927be4dd78a092c2d4008c1cd