Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Filip, Kovacic"'
Autor:
Arijit Chakraborty, Arunava Bandyopadhaya, Vijay K Singh, Filip Kovacic, Sujin Cha, William M Oldham, A Aria Tzika, Laurence G Rahme
Publikováno v:
eLife, Vol 13 (2024)
How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that Pseudomonas aeruginosa (PA), a recalcitrant pathogen, utilizes the quorum sensing (QS) signal 2
Externí odkaz:
https://doaj.org/article/d545ff885eb5410092dedd196b9b7566
Autor:
Rocco Gentile, Matea Modric, Björn Thiele, Karl-Erich Jaeger, Filip Kovacic, Stephan Schott-Verdugo, Holger Gohlke
Publikováno v:
JACS Au, Vol 4, Iss 3, Pp 958-973 (2024)
Externí odkaz:
https://doaj.org/article/8e03e285e20b4b20b281f0c947ea29ee
Autor:
Seungwoo Jeong, Vadim Schütz, Fatih Demir, Matthias Preusche, Pitter Huesgen, Laurent Bigler, Filip Kovacic, Katharina Gutbrod, Peter Dörmann, Margot Schulz
Publikováno v:
Plants, Vol 13, Iss 20, p 2897 (2024)
The continuous release of glucosinolates into the soil by Brassicaceae root exudation is a prerequisite to maintaining toxic levels of breakdown products such as isothiocyanates (ITCs). ITCs influence plant and microbial diversity in ecosystems, whil
Externí odkaz:
https://doaj.org/article/8d31e9cd7849478ab1c5d5dec14008de
Autor:
Athanasios Papadopoulos, Max Busch, Jens Reiners, Eymen Hachani, Miriam Baeumers, Julia Berger, Lutz Schmitt, Karl-Erich Jaeger, Filip Kovacic, Sander H. J. Smits, Alexej Kedrov
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Pseudomonas aeruginosa is a wide-spread opportunistic human pathogen and a high-risk factor for immunodeficient people and patients with cystic fibrosis. The extracellular lipase A belongs to the virulence factors of P. aeruginosa. Prior to the secre
Externí odkaz:
https://doaj.org/article/8c75dcca33a443e49cbb010527fa90cd
Autor:
Diana Hofmann, Björn Thiele, Meike Siebers, Mehdi Rahmati, Vadim Schütz, Seungwoo Jeong, Jiaxin Cui, Laurent Bigler, Federico Held, Bei Wu, Nikolina Babic, Filip Kovacic, Joachim Hamacher, Georg Hölzl, Peter Dörmann, Margot Schulz
Publikováno v:
Plants, Vol 12, Iss 15, p 2815 (2023)
Toxic breakdown products of young Camelina sativa (L.) Crantz, glucosinolates can eliminate microorganisms in the soil. Since microorganisms are essential for phosphate cycling, only insensitive microorganisms with phosphate-solubilizing activity can
Externí odkaz:
https://doaj.org/article/23642ac34f704d609ee2a164b5f538d2
Autor:
Pablo Perez-Garcia, Stefanie Kobus, Christoph G. W. Gertzen, Astrid Hoeppner, Nicholas Holzscheck, Christoph Heinrich Strunk, Harald Huber, Karl-Erich Jaeger, Holger Gohlke, Filip Kovacic, Sander H. J. Smits, Wolfgang R. Streit, Jennifer Chow
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
The structure of Igni18, ancient enzyme from the Crenarchaean species Ignicoccus hospitalis, is solved and characterized by Pérez-García, Chow and colleagues. This structure provides insight as to the evolution of metallo-beta-lactamases and their
Externí odkaz:
https://doaj.org/article/882f23538291485d9a533860520c28aa
Autor:
Florian Bleffert, Joachim Granzin, Muttalip Caliskan, Stephan N Schott-Verdugo, Meike Siebers, Björn Thiele, Laurence Rahme, Sebastian Felgner, Peter Dörmann, Holger Gohlke, Renu Batra-Safferling, Karl-Erich Jaeger, Filip Kovacic
Publikováno v:
eLife, Vol 11 (2022)
Cells steadily adapt their membrane glycerophospholipid (GPL) composition to changing environmental and developmental conditions. While the regulation of membrane homeostasis via GPL synthesis in bacteria has been studied in detail, the mechanisms un
Externí odkaz:
https://doaj.org/article/d52c3ae26f024011a92ce4cf8ef121ec
Autor:
Aldino Viegas, Peter Dollinger, Neha Verma, Jakub Kubiak, Thibault Viennet, Claus A. M. Seidel, Holger Gohlke, Manuel Etzkorn, Filip Kovacic, Karl-Erich Jaeger
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Folding and cellular localization of many proteins of Gram-negative bacteria rely on a network of chaperones and secretion systems. Among them is the lipase-specific foldase Lif, a membrane-bound steric chaperone that tightly binds (K D = 29
Externí odkaz:
https://doaj.org/article/1f6b74cffdfc456e8750adee00c92bc3
Autor:
Jonas Dittrich, Milana Popara, Jakub Kubiak, Mykola Dimura, Bastian Schepers, Neha Verma, Birte Schmitz, Peter Dollinger, Filip Kovacic, Karl-Erich Jaeger, Claus A. M. Seidel, Thomas-Otavio Peulen, Holger Gohlke
Publikováno v:
Journal of chemical theory and computation 19(8), 2389-2409 (2023). doi:10.1021/acs.jctc.2c01090
Maximum entropy methods (MEMs) determine posterior distributions by combining experimental data with prior information. MEMs are frequently used to reconstruct conformational ensembles of molecular systems for experimental information and initial mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe854fa9a332e7c21bf8b75bc222ad6
https://doi.org/10.1021/acs.jctc.2c01090
https://doi.org/10.1021/acs.jctc.2c01090
Autor:
Nikolina Babic, Filip Kovacic
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258385 (2021)
The efficacy of antibiotics to treat bacterial infections declines rapidly due to antibiotic resistance. This problem has stimulated the development of novel antibiotics, but most attempts have failed. Consequently, the idea of mining uncharacterized
Externí odkaz:
https://doaj.org/article/5bf7ea5f23ed421896a84ed0f712c142