Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

Autor: Sud, Amit, Thomsen, Hauke, Law, Philip J., Försti, Asta, Filho, Miguel Inacio Da Silva, Holroyd, Amy, Broderick, Peter, Orlando, Giulia, Lenive, Oleg, Wright, Lauren, Cooke, Rosie, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Eeles, Rosalind, Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Henderson, Brian E., Haiman, Christopher A., Benlloch, Sara, Schumacher, Fredrick R., Olama, Ali Amin Al, Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Stevens, Victoria L., Tangen, Catherine M., Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Cancel-Tassin, Géraldine, Koutros, Stella, Sorensen, Karina Dalsgaard, Maehle, Lovise, Neal, David E., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry, Lu, Yong-Jie, Giles, Graham G., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Dominguez, Manuela Gago, Roobol, Monique J., Menegaux, Florence, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Strandmann, Elke Pogge Von, Lightfoot, Tracy, Kane, Eleanor, Roman, Eve, Lake, Annette, Montgomery, Dorothy, Jarrett, Ruth F., Swerdlow, Anthony J., Engert, Andreas, Orr, Nick, Hemminki, Kari, Houlston, Richard S.

Publikováno v: Sud, A, Thomsen, H, Law, P J, Försti, A, Filho, M I D S, Holroyd, A, Broderick, P, Orlando, G, Lenive, O, Wright, L, Cooke, R, Easton, D, Pharoah, P, Dunning, A, Peto, J, Canzian, F, Eeles, R, Kote-Jarai, ZS, Muir, K, Pashayan, N, Hoffmann, P, Nöthen, M M, Jöckel, K-H, Strandmann, E P V, Lightfoot, T, Kane, E, Roman, E, Lake, A, Montgomery, D, Jarrett, R F, Swerdlow, A J, Engert, A, Orr, N, Hemminki, K, Houlston, R S & PRACTICAL consortium 2017, ' Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility ', Nature Communications, vol. 8, no. 1, pp. 1892 . https://doi.org/10.1038/s41467-017-00320-1
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The PRACTICAL Consortium 2017, ' Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility ', Nature Communications, vol. 8, no. 1, 1892 . https://doi.org/10.1038/s41467-017-00320-1
Sud, A, Thomsen, H, Law, P J, Försti, A, Filho, M I D S, Holroyd, A, Broderick, P, Orlando, G, Lenive, O, Wright, L, Cooke, R, Easton, D, Pharoah, P, Dunning, A, Peto, J, Canzian, F, Eeles, R, Kote-Jarai, ZS, Muir, K, Pashayan, N, The Practical Consortium, Henderson, B E, Haiman, C A, Benlloch, S, Schumacher, F R, Olama, A A A, Berndt, S I, Conti, D V, Wiklund, F, Chanock, S, Stevens, V L, Tangen, C M, Batra, J, Clements, J, Gronberg, H, Schleutker, J, Albanes, D, Weinstein, S, Wolk, A, West, C, Mucci, L, Cancel-Tassin, G, Koutros, S, Sorensen, K D, Maehle, L, Neal, D E, Travis, R C, Hamilton, R J, Ingles, S A, Rosenstein, B & Nordestgaard, B G 2017, ' Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility ', Nature Communications, vol. 8, 1892 . https://doi.org/10.1038/s41467-017-00320-1
Sud, A, Thomsen, H, Law, P J, Försti, A, Filho, M I D S, Holroyd, A, Broderick, P, Orlando, G, Lenive, O, Wright, L, Cooke, R, Easton, D, Pharoah, P, Dunning, A, Peto, J, Canzian, F, Eeles, R, Kote-Jarai, ZS, Muir, K, Pashayan, N, Henderson, B E, Haiman, C A, Benlloch, S, Schumacher, F R, Olama, A A A, Berndt, S I, Conti, D V, Wiklund, F, Chanock, S, Stevens, V L, Tangen, C M, Batra, J, Clements, J, Gronberg, H, Schleutker, J, Albanes, D, Weinstein, S, Wolk, A, West, C, Mucci, L, Cancel-Tassin, G, Koutros, S, Sorensen, K D, Maehle, L, Neal, D E, Travis, R C, Hamilton, R J, Ingles, S A, Rosenstein, B, Lu, Y J, Giles, G G, Kibel, A S, Vega, A, Kogevinas, M, Penney, K L, Park, J Y, Stanford, J L, Cybulski, C, Nordestgaard, B G, Brenner, H, Maier, C, Kim, J, John, E M, Teixeira, M R, Neuhausen, S L, De Ruyck, K, Razack, A, Newcomb, L F, Lessel, D, Kaneva, R, Usmani, N, Claessens, F, Townsend, P A, Dominguez, M G, Roobol, M J, Menegaux, F, Hoffmann, P, Nöthen, M M, Jöckel, K H, Strandmann, E P V, Lightfoot, T, Kane, E, Roman, E, Lake, A, Montgomery, D, Jarrett, R F, Swerdlow, A J, Engert, A, Orr, N, Hemminki, K & Houlston, R S 2017, ' Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility ', Nature Communications, vol. 8, no. 1, 1892 . https://doi.org/10.1038/s41467-017-00320-1

Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and

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Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population.

Autor: Marouf, Chaymaa, Göhler, Stella, Da Silva Filho, Miguel Inacio, Hajji, Omar, Hemminki, Kari, Nadifi, Sellama, Försti, Asta, Filho, Miguel Inacio Da Silva

Publikováno v: BMC Cancer; 2/26/2016, Vol. 16, p1-11, 11p, 5 Charts

Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility.

Autor: Sud A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Thomsen H; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, 69120, Germany., Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Försti A; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, 69120, Germany.; Centre for Primary Health Care Research, Lund University, Malmö, 221 00, Sweden., Filho MIDS; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, 69120, Germany., Holroyd A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Broderick P; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Orlando G; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Lenive O; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Wright L; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Cooke R; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Easton D; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Pharoah P; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Dunning A; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK., Peto J; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK., Canzian F; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany., Eeles R; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.; Royal Marsden NHS Foundation Trust, London, SM2 5NG, UK., Kote-Jarai Z; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK., Muir K; Institute of Population Health, University of Manchester, Manchester, M1 3BB, UK.; Division of Health Sciences, Warwick Medical School, Warwick University, Warwick, CV4 7AL, UK., Pashayan N; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; Department of Applied Health Research, University College London, London, WC1E 7HB, UK., Hoffmann P; Department of Biomedicine, Division of Medical Genetics, University of Basel, Basel, 4031, Switzerland.; Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, 53127, Germany., Jöckel KH; University of Duisburg-Essen, Essen, 47057, Germany., Strandmann EPV; Department of Internal Medicine, University Hospital of Cologne, Cologne, 50937, Germany., Lightfoot T; Department of Health Sciences, University of York, York, YO10 5DD, UK., Kane E; Department of Health Sciences, University of York, York, YO10 5DD, UK., Roman E; Department of Health Sciences, University of York, York, YO10 5DD, UK., Lake A; MRC University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK., Montgomery D; MRC University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK., Jarrett RF; MRC University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK., Swerdlow AJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.; Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK., Engert A; Department of Internal Medicine, University Hospital of Cologne, Cologne, 50937, Germany., Orr N; Division of Molecular Pathology, The Institute of Cancer Research, London, SW7 3RP, UK., Hemminki K; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, 69120, Germany.; Centre for Primary Health Care Research, Lund University, Malmö, 221 00, Sweden., Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK. richard.houlston@icr.ac.uk.; Division of Molecular Pathology, The Institute of Cancer Research, London, SW7 3RP, UK. richard.houlston@icr.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2017 Dec 01; Vol. 8 (1), pp. 1892. Date of Electronic Publication: 2017 Dec 01.