HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33

Autor: Osbourn, M, Soares, DC, Vacca, F, Cohen, ES, Scott, IC, Gregory, WF, Smyth, DJ, Toivakka, M, Kemter, AM, le, Bihan T, Wear, M, Hoving, D, Filbey, KJ, Hewitson, JP, McSorley, HJ

Publikováno v: Osbourn, M, Soares, DC, Vacca, F, Cohen, ES, Scott, IC, Gregory, WF, Smyth, DJ, Toivakka, M, Kemter, AM, le, B T, Wear, M, Hoving, D, Filbey, KJ, Hewitson, JP & McSorley, HJ 2017, ' HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33. ', Immunity . https://doi.org/10.1016/j.immuni.2017.09.015

Infection by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic insights into this association are lacking. Products secreted by the mouse parasite Heligmosomoides polygyrus suppress type 2 (allergic) immune re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::020145deedcbf65e139b1106cb83fe05
https://doi.org/10.1016/j.immuni.2017.09.015

The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF).

Autor: Varyani F; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK., Löser S; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Filbey KJ; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK.; Lydia Becker Institute for Immunology and Inflammation, University of Manchester, Manchester, UK., Harcus Y; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK., Drurey C; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Poveda MC; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Rasid O; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., White MPJ; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Smyth DJ; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.; Division of Cell Signalling and Immunology, University of Dundee, Dundee, UK., Gerbe F; IGF, University of Montpellier, CNRS, Inserm, Montpellier, France., Jay P; IGF, University of Montpellier, CNRS, Inserm, Montpellier, France., Maizels RM; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK. rick.maizels@glasgow.ac.uk.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2022 Jun; Vol. 15 (6), pp. 1243-1256. Date of Electronic Publication: 2022 Mar 14.

Cell surface IL-1α trafficking is specifically inhibited by interferon-γ, and associates with the membrane via IL-1R2 and GPI anchors.

Autor: Chan JNE; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Humphry M; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Kitt L; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Krzyzanska D; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Filbey KJ; Manchester Collaborative Centre for Inflammation Research, Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Core Technology Facility, Manchester, UK., Bennett MR; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Clarke MCH; Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

Publikováno v: European journal of immunology [Eur J Immunol] 2020 Nov; Vol. 50 (11), pp. 1663-1675. Date of Electronic Publication: 2020 Jun 08.

Macrophage Migration Inhibitory Factor (MIF) Is Essential for Type 2 Effector Cell Immunity to an Intestinal Helminth Parasite.

Autor: Filbey KJ; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom., Varyani F; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Harcus Y; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom., Hewitson JP; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom., Smyth DJ; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., McSorley HJ; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Ivens A; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom., Nylén S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden., Rottenberg M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden., Löser S; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom., Maizels RM; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 Oct 24; Vol. 10, pp. 2375. Date of Electronic Publication: 2019 Oct 24 (Print Publication: 2019).

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

Autor: Johnston CJC; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Department of Clinical Surgery, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Smyth DJ; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK., Kodali RB; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Aveue, Pittsburgh, PA, 15260, USA., White MPJ; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK., Harcus Y; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK., Filbey KJ; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Malaghan Institute of Medical Research, PO Box 7080, Wellington, 6242, New Zealand., Hewitson JP; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Department of Biology, University of York, York, YO10 5DD, UK., Hinck CS; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Aveue, Pittsburgh, PA, 15260, USA., Ivens A; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK., Kemter AM; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK., Kildemoes AO; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Section for Parasitology and Aquatic Diseases, Department of Veterinary Disease Biology, University of Copenhagen, Copenhagen, DK-1870, Denmark., Le Bihan T; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK., Soares DC; MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Anderton SM; MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Brenn T; Department of Pathology, Western General Hospital, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Wigmore SJ; Department of Clinical Surgery, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Woodcock HV; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, WC1E 6JF, UK., Chambers RC; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, WC1E 6JF, UK., Hinck AP; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Aveue, Pittsburgh, PA, 15260, USA., McSorley HJ; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Maizels RM; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK. rick.maizels@glasgow.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2017 Nov 23; Vol. 8 (1), pp. 1741. Date of Electronic Publication: 2017 Nov 23.